Results 1 to 10 of about 28,209 (250)

Structural insights on ligand recognition at the human leukotriene B4 receptor 1

Nature Communications, 2021
Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4.
Nairie Michaelian, Anastasiia Sadybekov, Élie Besserer-Offroy, Gye Won Han, Harini Krishnamurthy, Beata A. Zamlynny, Xavier Fradera, Phieng Siliphaivanh, Jeremy Presland, Kerrie B. Spencer, Stephen M. Soisson, Petr Popov, Philippe Sarret, Vsevolod Katritch, Vadim Cherezov   +14 more
doaj   +2 more sources

Root canal contamination or exposure to lipopolysaccharide differentially modulate prostaglandin E 2 and leukotriene B 4 signaling in apical periodontitis [PDF]

Journal of Applied Oral Science, 2020
Purpose To evaluate the kinetics of apical periodontitis development in vivo , induced either by contamination of the root canals by microorganisms from the oral cavity or by inoculation of bacterial lipopolysaccharide (LPS) and the regulation of major ...
Francisco Wanderley Garcia PAULA-SILVA, Fernanda Regina RIBEIRO-SANTOS, Igor Bassi Ferreira PETEAN, Maya Fernanda MANFRIN ARNEZ, Luciano Aparecido de ALMEIDA-JUNIOR, Fabrício Kitazono de CARVALHO, Léa Assed Bezerra da SILVA, Lúcia Helena FACCIOLI   +7 more
doaj   +2 more sources

Structure-based identification of compounds with potential as selective BLT1 antagonists [PDF]

Scientific Reports
The pro-inflammatory molecule leukotriene B4 binds to the leukotriene B4 receptors 1 and 2 (BLT1 and BLT2). Although BLT1 has potential as a target for treating inflammatory diseases, no selective BLT1 antagonist has been marketed to date.
Reem A. Alkhodier, Saud A. Alshamrani, Omar S. Almutlaq, Maali D. Alshammari   +3 more
doaj   +2 more sources

The effectiveness of unfractionated heparin vs. low molecular weight (Enoxaparin) in Acute Respiratory Distress Syndrom (ARDS) and metabolic dysfunction: an old drug for new indication! [PDF]

BMC Immunology
Background Acute Respiratory Distress Syndrome is a lung disorder defined by the acute onset of hypoxemia, the commonest being abdominal sepsis.Many biomarkers have been studied for diagnostic prognostication and ARDS pharmacotherapy.
Shabnam Delasoud, Mojtaba Mojtahedzadeh, Mohammad Sharifzadeh, Mohammad Hossein Ghahremani, Abbass Kebriaeezadeh, Maryam Gholami, Samin Sabzevari, Omid Sabzevari   +7 more
doaj   +2 more sources

A Second Leukotriene B4 Receptor, Blt2 [PDF]

Journal of Experimental Medicine, 2000
Leukotriene B4 (LTB4) is a potent chemoattractant and activator of both granulocytes and macrophages. The actions of LTB4 appear to be mediated by a specific G protein–coupled receptor (GPCR) BLT1, originally termed BLT (Yokomizo, T., T. Izumi, K. Chang, Y. Takuwa, and T. Shimizu. 1997. Nature. 387:620–624).
Takehiko Yokomizo, Kazuhiko Kato, Takashi Izumi   +2 more
exaly   +2 more sources

Omega-3 DHA as a blank canvas: A molecular approximation to how lipid mediators modulate LGR6 in inflammation resolution. [PDF]

Protein Sci
Abstract The leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane‐embeded systems, to understand the activation mechanism ...
Pérez-Sánchez Á, Garcia-Viloca M, González-Lafont À, Lluch JM.   +3 more
europepmc   +2 more sources

Leukotriene B4 receptor 1 (BLT1) activation by leukotriene B4 (LTB₄) and E resolvins (RvE1 and RvE2). [PDF]

Comput Biol Chem
Leukotriene B4 (LTB4) is a lipid inflammatory mediator derived from arachidonic acid (AA). Leukotriene B4 receptor 1 (BLT1), a G protein-coupled receptor (GPCR), is a receptor of LTB4. Nonetheless, the resolution of inflammation is driven by specialized pro-resolving lipid mediators (SPMs) such as resolvins E1 (RvE1) and E2 (RvE2).
Nunes VS, Rogério AP, Abrahão O, Serhan CN.   +3 more
europepmc   +4 more sources

The regulatory action of acetylcholine and its receptors on B4 and C4 leukotriene formation in the porcine endometrium after experimental inflammogenic Escherichia coli infection [PDF]

Journal of Veterinary Research
Endometritis is a very common pathology in animals which changes endometrial leukotriene (LT) formation and muscarinic 2 and 3 receptor subtypes (M2R/M3R) and α-7 nicotinic acetylcholine (ACh) receptor (α-7 nAChR) expression patterns.
Jana Barbara, Całka Jarosław, Bulc Michał, Kawka Dominika   +3 more
doaj   +2 more sources

Purinergic signaling: A new front-line determinant of resistance and susceptibility in leishmaniasis

Biomedical Journal, 2022
Leishmaniasis is a neglected tropical disease that causes several clinical manifestations. Parasites of the genus Leishmania cause this disease. Spread across five continents, leishmaniasis is a particular public health problem in developing countries ...
Mariana Chaves, Luiz Eduardo Savio, Robson Coutinho-Silva   +2 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source