Results 21 to 30 of about 9,657 (181)
Regulation of Immune Cells by Eicosanoid Receptors
The Scientific World Journal, 2007 Eicosanoids are potent, bioactive, lipid mediators that regulate important components of the immune response, including defense against infection, ischemia, and injury, as well as instigating and perpetuating autoimmune and inflammatory conditions ...
Nancy D. Kim, Andrew D. Luster
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Structural basis of leukotriene B4 receptor 1 activation
Nature Communications, 2022 AbstractLeukotriene B4 receptor 1 (BLT1) plays crucial roles in the acute inflammatory responses and is a valuable target for anti-inflammation treatment, however, the mechanism by which leukotriene B4 (LTB4) activates receptor remains unclear. Here, we report the cryo-electron microscopy (cryo-EM) structure of the LTB4 -bound human BLT1 in complex ...
Na Wang +7 more
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Mediators of Inflammation, 2015 Accumulating evidence indicates that leukotriene B4 (LTB4) via its receptors BLT1 and/or BLT2 (BLTRs) could have an important role in regulating infection, tumour progression, inflammation, and autoimmune diseases.
Meng Wang +4 more
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Leukotriene B4 Receptor and the Function of Its Helix 8 [PDF]
Journal of Biological Chemistry, 2005 More than 30 lipid ligands, which express their biological activities through cognate G-protein-coupled receptors (GPCRs), have been reported. Among them, leukotriene B(4) (LTB(4)) is a potent lipid mediator involved in host defense, inflammation, and the immune responses. Two GPCRs for LTB(4) (BLT1 and BLT2) have been cloned and analyzed.
Toshiaki, Okuno +4 more
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Frontiers in Immunology, 2018 The release of damage-associated molecular patterns, including uridine triphosphate (UTP) and adenosine triphosphate (ATP) to the extracellular milieu is a key component of innate immune response to infection.
Maria Luiza Thorstenberg +6 more
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Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. [PDF]
PLoS ONE, 2017 Leukotriene B4 (LTB4) receptor 1 (BLT1) is a G protein-coupled receptor expressed in various leukocyte subsets; however, the precise expression of mouse BLT1 (mBLT1) has not been reported because a mBLT1 monoclonal antibody (mAb) has not been available ...
Fumiyuki Sasaki +7 more
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Arachidonic acid and calcium metabolism in rnelittin stimulated neutrophils
Mediators of Inflammation, 1992 Melittin, the predominant fraction of bee venom proteins, was studied in an experimental model of human neutrophil granulocytes to reveal its influence on eicosanoid release, metabolism and receptor function in relation to intracellular calcium ...
Ole H. Nielsen +2 more
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CD36 Shunts Eicosanoid Metabolism to Repress CD14 Licensed Interleukin-1β Release and Inflammation
Frontiers in Immunology, 2018 Interleukin (IL)-1β is a potential target for treatment of several inflammatory diseases, including envenomation by the scorpion Tityus serrulatus.
Karina F. Zoccal +11 more
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Biochemical characterization of three BLT receptors in zebrafish.
PLoS ONE, 2015 The leukotriene B4 (LTB4) receptor 1 (BLT1) is a high affinity receptor for LTB4, a chemotactic and inflammatory eicosanoid. The LTB4 receptor 2 (BLT2) was originally identified as a low affinity receptor for LTB4, and, more recently, as a high affinity ...
Toshiaki Okuno +2 more
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Molecular Cloning and Characterization of Another Leukotriene B4 Receptor
Journal of Biological Chemistry, 2000 Leukotriene B(4) is a potent lipid mediator known to be implicated mainly in inflammatory actions. Previous pharmacological studies indicated the existence of only one class of G protein-coupled receptor for leukotriene B(4), for which a candidate gene, namely BLT, had been identified.
M, Kamohara +6 more
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