Results 31 to 40 of about 9,646 (180)

Arachidonic acid and calcium metabolism in rnelittin stimulated neutrophils

Mediators of Inflammation, 1992
Melittin, the predominant fraction of bee venom proteins, was studied in an experimental model of human neutrophil granulocytes to reveal its influence on eicosanoid release, metabolism and receptor function in relation to intracellular calcium ...
Ole H. Nielsen, Pierre N. Bouchelouche, Dag Berild   +2 more
doaj   +1 more source

CD36 Shunts Eicosanoid Metabolism to Repress CD14 Licensed Interleukin-1β Release and Inflammation

Frontiers in Immunology, 2018
Interleukin (IL)-1β is a potential target for treatment of several inflammatory diseases, including envenomation by the scorpion Tityus serrulatus.
Karina F. Zoccal, Luiz G. Gardinassi, Carlos A. Sorgi, Alyne F. G. Meirelles, Karla C. F. Bordon, Isaias Glezer, Palmira Cupo, Alessandra K. Matsuno, Valdes R. Bollela, Eliane C. Arantes, Francisco S. Guimarães, Lúcia Helena Faccioli   +11 more
doaj   +1 more source

Molecular Cloning and Characterization of Another Leukotriene B4 Receptor

Journal of Biological Chemistry, 2000
Leukotriene B(4) is a potent lipid mediator known to be implicated mainly in inflammatory actions. Previous pharmacological studies indicated the existence of only one class of G protein-coupled receptor for leukotriene B(4), for which a candidate gene, namely BLT, had been identified.
M, Kamohara, J, Takasaki, M, Matsumoto, T, Saito, T, Ohishi, H, Ishii, K, Furuichi   +6 more
openaire   +2 more sources

Biochemical characterization of three BLT receptors in zebrafish.

PLoS ONE, 2015
The leukotriene B4 (LTB4) receptor 1 (BLT1) is a high affinity receptor for LTB4, a chemotactic and inflammatory eicosanoid. The LTB4 receptor 2 (BLT2) was originally identified as a low affinity receptor for LTB4, and, more recently, as a high affinity ...
Toshiaki Okuno, Tohru Ishitani, Takehiko Yokomizo   +2 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Leukotriene Enhances NMDA-Induced Inward Currents in Dorsal Horn Neurons of the Rat Spinal Cord after Peripheral Nerve Injury

Molecular Pain, 2015
Background LTB4 is classified as a leukotriene (LT), a group of lipid mediators that are derived from arachidonic acid. It is recognized that leukotrienes are involved in the pathogenesis of many diseases, including peripheral inflammatory pain. However,
Yasukuni Kiyoyuki, Wataru Taniguchi, Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Naoko Nishio, Terumasa Nakatsuka, Koichi Noguchi   +7 more
doaj   +1 more source

Mast cell chemotaxis – Chemoattractants and signaling pathways

Frontiers in Immunology, 2012
Migration of mast cells is essential for their recruitment within target tissues where they play an important role in innate and adaptive immune responses. These processes rely on the ability of mast cells to recognize appropriate chemotactic stimuli and
Ivana eHalova, Lubica eDraberova, Petr eDraber   +2 more
doaj   +1 more source

Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators

Scientific Reports, 2022
Many conjunctival inflammatory diseases differ between the sexes and altered conjunctival goblet cells (CGCs) response is often involved. Inflammation is initiated by the release of pro-inflammatory mediators and terminated by the biosynthesis of ...
Menglu Yang, Haakon K. Fjærvoll, Ketil A. Fjærvoll, Nicholas H. Wang, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt   +6 more
doaj   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Role of the BLT2, a leukotriene B4 receptor, in Ras transformation [PDF]

Oncogene, 2004
Oncogenic Ras is known to drive both the Rac and Raf-MAP-kinase pathways, which act in concert to cause cell transformation. Unlike the Raf-MAP-kinase cascade, however, the downstream elements of Rac pathway are not fully understood. Previously, we showed that cytosolic phospholipase A2 (cPLA2) and subsequent metabolism of arachidonic acid act ...
Min-Hyuk, Yoo, Haiwon, Song, Chang-Hoon, Woo, Heunggyu, Kim, Jae-Hong, Kim   +4 more
openaire   +2 more sources