Results 51 to 60 of about 17,556 (218)

Biochemical characterization of three BLT receptors in zebrafish.

PLoS ONE, 2015
The leukotriene B4 (LTB4) receptor 1 (BLT1) is a high affinity receptor for LTB4, a chemotactic and inflammatory eicosanoid. The LTB4 receptor 2 (BLT2) was originally identified as a low affinity receptor for LTB4, and, more recently, as a high affinity ...
Toshiaki Okuno, Tohru Ishitani, Takehiko Yokomizo   +2 more
doaj   +1 more source

Two distinct leukotriene B4 receptors, BLT1 and BLT2 [PDF]

Journal of Biochemistry, 2014
Leukotriene B4 (LTB4) is a potent inflammatory mediator derived from arachidonic acid. Two G protein-coupled receptors for LTB4 have been identified: a high-affinity receptor, BLT1, and a low-affinity receptor, BLT2. Both receptors mainly couple to pertussis toxin-sensitive Gi-like G proteins and induce cell migration.
openaire   +2 more sources

Leukotriene B4 Receptor-1 Mediates Intermittent Hypoxia-induced Atherogenesis [PDF]

American Journal of Respiratory and Critical Care Medicine, 2011
Obstructive sleep apnea, which is characterized by intermittent hypoxia (IH) during sleep, has emerged as an independent risk factor for cardiovascular disease, including atherosclerosis. Leukotriene B4 (LTB4) production is increased in patients with obstructive sleep apnea and negatively correlates to hypoxic levels during sleep, with continuous ...
Richard C, Li, Bodduluri, Haribabu, Steven P, Mathis, Jinkwan, Kim, David, Gozal   +4 more
openaire   +2 more sources

Antimicrobial peptides and eicosanoids : roles and interactions in inflammation and host defense [PDF]

, 2017
Antimicrobial peptides (AMPs) have a broad spectrum of activities and exert their functions by both direct killing of microbes through the interaction with the microbial membrane, and modulation of innate and adaptive immunity of the host.
Tang, Xiao
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Leukotriene Enhances NMDA-Induced Inward Currents in Dorsal Horn Neurons of the Rat Spinal Cord after Peripheral Nerve Injury

Molecular Pain, 2015
Background LTB4 is classified as a leukotriene (LT), a group of lipid mediators that are derived from arachidonic acid. It is recognized that leukotrienes are involved in the pathogenesis of many diseases, including peripheral inflammatory pain. However,
Yasukuni Kiyoyuki, Wataru Taniguchi, Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Naoko Nishio, Terumasa Nakatsuka, Koichi Noguchi   +7 more
doaj   +1 more source

Mast cell chemotaxis – Chemoattractants and signaling pathways

Frontiers in Immunology, 2012
Migration of mast cells is essential for their recruitment within target tissues where they play an important role in innate and adaptive immune responses. These processes rely on the ability of mast cells to recognize appropriate chemotactic stimuli and
Ivana eHalova, Lubica eDraberova, Petr eDraber   +2 more
doaj   +1 more source

Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators

Scientific Reports, 2022
Many conjunctival inflammatory diseases differ between the sexes and altered conjunctival goblet cells (CGCs) response is often involved. Inflammation is initiated by the release of pro-inflammatory mediators and terminated by the biosynthesis of ...
Menglu Yang, Haakon K. Fjærvoll, Ketil A. Fjærvoll, Nicholas H. Wang, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt   +6 more
doaj   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Stimulus specificity of the generation of leukotrienes by dog mastocytoma cells. [PDF]

, 1983
Isolated dog mastocytoma cells sensitized with dog anti-ragweed IgE and challenged with ragweed antigen or incubated with ionophore A23187 or the carboxy-terminal dodecapeptide of platelet factor 4, PF4(59-70), release histamine and concurrently generate
Goetzl, EJ, Gold, WM, Phillips, MJ
core