A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis
Arthritis &Rheumatology, EarlyView.Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun +13 more
wiley +1 more source
Data in Brief, 2019 Macrophages are classified mainly into two subtypes, M1 and M2, which exhibit distinct phenotypes, based on their microenvironment. We have recently demonstrated that Gpr137b is abundantly expressed in RAW264 macrophages, “Gpr137b is an orphan G-protein ...
Zohirul Islam +3 more
doaj +1 more source
Augmentation of 5-lipoxygenase activity and expression during dengue serotype-2 infection [PDF]
, 2013 published_or_final_versio
Chow, AY +8 more
core +1 more source
EP80317 Restrains Inflammation and Mortality Caused by Scorpion Envenomation in Mice
Frontiers in Pharmacology, 2019 Over 1 million cases of scorpion stings are estimated every year, whereas current treatment is limited to antivenom serum combined with supportive therapy.
Karina F. Zoccal +7 more
doaj +1 more source
Molecular Cloning and Characterization of Another Leukotriene B4 Receptor
Journal of Biological Chemistry, 2000 Leukotriene B(4) is a potent lipid mediator known to be implicated mainly in inflammatory actions. Previous pharmacological studies indicated the existence of only one class of G protein-coupled receptor for leukotriene B(4), for which a candidate gene, namely BLT, had been identified.
M, Kamohara +6 more
openaire +2 more sources
Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation [PDF]
, 2014 MicroRNAs are known to control TLR activation in phagocytes. We have shown that leukotriene (LT) B4 (LTB4) positively regulates macrophage MyD88 expression by decreasing suppressor of cytokine signaling-1 (SOCS-1) mRNA stability.
Filgueiras, Luciano +6 more
core +1 more source
Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food
Allergy, EarlyView.ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy +7 more
wiley +1 more source
A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. [PDF]
, 1993 Using an in vivo test system, the role of the β1 integrin very late activation antigen-4 (VLA-4) in eosinophil accumulation in allergic and nonallergic inflammatory reactions was investigated.
Lobb, RR +3 more
core +1 more source
Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms
British Journal of Pharmacology, EarlyView.The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl +3 more
wiley +1 more source
Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis in Rats
International Journal of Inflammation, 2016 Nicotine is protective in ulcerative colitis but not Crohn’s disease of the small intestine, but little is known about the effects of nicotine on Clostridium difficile toxin A-induced enteritis.
Steven R. Vigna
doaj +1 more source