Results 11 to 20 of about 9,657 (181)
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Role of leukotriene B4 receptors in rheumatoid arthritis [PDF]
Autoimmunity Reviews, 2007 The purpose of this review is to summarize the role that murine models of arthritis are playing in the understanding of human rheumatoid arthritis and how leukotriene B(4) (LTB(4)) is emerging as an important target in this field. Both the collagen-induced arthritis (CIA) model and the K/BxN serum transfer arthritis model have contributed to outline ...
Steven, Mathis +2 more
openaire +2 more sources
Frontiers in Immunology, 2018 Given the importance of high-mobility group box 1 (HMGB1) and 5-lipoxygenase (5-LO) signaling in vascular inflammation, we investigated the role of leukotriene signaling in monocytes on monocyte-to-macrophage differentiation (MMD) induced by HMGB1, and ...
Seung E. Baek +9 more
doaj +1 more source
Journal of Pharmacological Sciences, 2007 This study investigated endogenous mediators involved in mosquito allergy-associated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice.
Yasushi Kuraishi +6 more
doaj +1 more source
Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice. [PDF]
PLoS Pathogens, 2018 The early events that shape the innate immune response to restrain pathogens during skin infections remain elusive. Methicillin-resistant Staphylococcus aureus (MRSA) infection engages phagocyte chemotaxis, abscess formation, and microbial clearance ...
Stephanie L Brandt +7 more
doaj +1 more source
PPAR Research, 2008 Pancreatic cancer is a devastating disease in which current therapies are inadequate. Separate lines of research have identified the 5-lipoxygenase/leukotriene B4 receptor pathway and the PPAR𝛾 pathway as potential targets for prevention or treatment of ...
Thomas E. Adrian +3 more
doaj +1 more source
Biomolecules, 2022 Diabetes mellitus, a well-established risk factor for stroke, is related to higher mortality and poorer outcomes following the stroke event. Advanced glycation end products(AGEs), their receptors RAGEs, other ligands, and several other processes ...
Nivedita L. Rao +8 more
doaj +1 more source
Cell Journal, 2018 Objective We aimed at characterizing the transcription profiles of immunological receptors associated with the biology of mesenchymal stromal cells (MSCs).
Mehdi Najar +6 more
doaj +1 more source
Frontiers in Immunology, 2023 Sepsis is defined as a life-threatening dysfunction due to a dysregulated host response to infection. It is a common and complex syndrome and is the leading cause of death in intensive care units. The lungs are most vulnerable to the challenge of sepsis,
Yi Wang +12 more
doaj +1 more source