Results 11 to 20 of about 28,209 (250)

The Role of PPAR𝛾 Receptors and Leukotriene B4 Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer

PPAR Research, 2008
Pancreatic cancer is a devastating disease in which current therapies are inadequate. Separate lines of research have identified the 5-lipoxygenase/leukotriene B4 receptor pathway and the PPAR𝛾 pathway as potential targets for prevention or treatment of ...
Thomas E. Adrian, Rene Hennig, Helmut Friess, Xianzhong Ding   +3 more
doaj   +3 more sources

The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons

Journal of Biological Chemistry, 2022
S.6123-6134Sensitization of the heat-activated ion channel transient receptor potential vanilloid 1 (TRPV1) through lipids is a fundamental mechanism during inflammation-induced peripheral sensitization. Leukotriene B4 is a proinflammatory lipid mediator
Treutlein, E.M., Pierre, S., Scholich, K., Tunaru, S., Ferreiros, N., Geisslinger, G., Offermanns, S., Zinn, S., Leffler, A., DeBruin, N., Angioni, C., Kern, K., Suo, J., Jordan, H., Sisignano, M.   +14 more
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Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis [PDF]

Arthritis Research & Therapy, 2014
IntroductionBone erosion in inflammatory arthritis depends on the recruitment and activation of bone resorbing cells, the osteoclasts. Interleukin-23 (IL-23) has been primarily implicated in mediating inflammatory bone loss via the differentiation of ...
Borodinsky, Laura N, Adamopoulos, Iannis E, Belgacem, Yesser H, Wu, Dennis J, Gershwin, M Eric, Dixit, Neha   +5 more
core   +2 more sources

Two distinct leukotriene B4 receptors, BLT1 and BLT2 [PDF]

Journal of Biochemistry, 2014
Leukotriene B4 (LTB4) is a potent inflammatory mediator derived from arachidonic acid. Two G protein-coupled receptors for LTB4 have been identified: a high-affinity receptor, BLT1, and a low-affinity receptor, BLT2. Both receptors mainly couple to pertussis toxin-sensitive Gi-like G proteins and induce cell migration.
T. Yokomizo
openaire   +3 more sources

Differential Contribution of BLT1 and BLT2 to Leukotriene B4-Induced Human NK Cell Cytotoxicity and Migration [PDF]

Mediators of Inflammation, 2015
Accumulating evidence indicates that leukotriene B4 (LTB4) via its receptors BLT1 and/or BLT2 (BLTRs) could have an important role in regulating infection, tumour progression, inflammation, and autoimmune diseases.
Meng Wang, Nermine Mostafa El-Maghraby, Sylvie Turcotte, Marek Rola-Pleszczynski, Jana Stankova   +4 more
doaj   +2 more sources

Nonredundant Roles for Leukotriene B4 Receptors BLT1 and BLT2 in Inflammatory Arthritis

Journal of Immunology, 2010
Lipid mediators derived from arachidonic acid through the cyclooxygenase and lipoxygenase pathways are known to be important mediators of inflammation. Studies in mouse models demonstrated an important role for the high-affinity leukotriene B4 receptor ...
David M. Lee, Venkatakrishna R. Jala, Bodduluri Haribabu, Steven P. Mathis   +3 more
core   +2 more sources

Protein kinase C regulates leukotriene B4 receptors in human neutrophils

FEBS Letters, 1986
Three protein kinase C (PKC) activators, viz. phorbol myristate acetate, mezerein, and rac-1-O-myristoyl-2-acetylglycerol, inhibited human neutrophil binding of [3H] leukotriene B4 (LTB4) by reducing the number of high-affinity receptors available to the
Joseph T. O'Flaherty, Jimmy F. Redman, Redman, Jimmy F., David P. Jacobson, O'Flaherty, Joseph T., Jacobson, David P.   +5 more
core   +2 more sources

Role of Leukotriene B4 Receptors in the Development of Atherosclerosis: Potential Mechanisms

Arteriosclerosis, Thrombosis and Vascular Biology, 2004
Objective-Leukotriene B4 (LTB4), a potent leukocyte chemoattractant, is known to promote several inflammatory diseases, including atherosclerosis. We sought to determine mechanisms through which LTB 4 modulates atherosclerosis in cell lines expressing ...
Tseng, Michael T, Subbarao, Krishnaprasad, Haribabu, Bodduluri, Mathis, Steven, Ali, Hydar, Jala, Venkatakrishna R.   +5 more
core   +2 more sources

Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. [PDF]

PLoS ONE, 2017
Leukotriene B4 (LTB4) receptor 1 (BLT1) is a G protein-coupled receptor expressed in various leukocyte subsets; however, the precise expression of mouse BLT1 (mBLT1) has not been reported because a mBLT1 monoclonal antibody (mAb) has not been available ...
Fumiyuki Sasaki, Tomoaki Koga, Kazuko Saeki, Toshiaki Okuno, Saiko Kazuno, Tsutomu Fujimura, Yasuyuki Ohkawa, Takehiko Yokomizo   +7 more
doaj   +2 more sources

Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection.

PLoS ONE, 2015
Leukotriene B4 (LTB4), a central mediator of inflammation, is well known for its chemoattractant properties on effectors cells of the immune system. LTB4 also has the ability to control microbial infection by improving host innate defenses through the ...
Manon Le Bel, Jean Gosselin
doaj   +2 more sources