Results 41 to 50 of about 18,529 (226)

Serum leukotriene B4 and hydroxyeicosatetraenoic acid in the prediction of pre-eclampsia

, 2021
Introduction: Pre-eclampsia (PE) affects 2–8% of pregnancies worldwide. Despite identification of numerous possible biomarkers, accurate prediction and early diagnosis of PE remain challenging.
Nicolaides, KH, Da Silva Costa, F, Santos, LL, Wertaschnigg, D, Dimitriadis, E, Rolnik, DL, Syngelaki, A   +6 more
core   +1 more source

Metabolism of oxygenated derivatives of arachidonic acid by Caco-2 cells.

Journal of Lipid Research, 1992
Monolayers of Caco-2 cells, a human enterocyte cell line, were incubated separately with 3H8-labeled preparations of three different lipid mediators of inflammation: 5-hydroxyeicosatetraenoic acid, 12-hydroxyeicosatetraenoic acid, and leukotriene B4 ...
TE Riehl, J Turk, WF Stenson
doaj   +1 more source

Berberine Alleviates Insulin Resistance and Inflammation via Inhibiting the LTB4–BLT1 Axis

Frontiers in Pharmacology, 2021
Background: Chronic low-grade inflammation is recognized as a key pathophysiological mechanism of insulin resistance. Leukotriene B4 (LTB4), a molecule derived from arachidonic acid, is a potent neutrophil chemoattractant.
Minmin Gong, Huiyan Duan, Fan Wu, Yanlin Ren, Jing Gong, Lijun Xu, Fuer Lu, Dingkun Wang   +7 more
doaj   +1 more source

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, EarlyView.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

Production of Intraepidermal Microabscesses by Topical Application of Leukotriene B4

, 1984
Leukotriene B4 is a highly potent leukocyte chemotactic compound. It has been identified in chamber fluid and scale from psoriatic skin lesions, in which epidermal neutrophil infiltration is reported to be one of the earliest pathologic events.
Brain, Susan, Camp, Richard, Woollard, Patrick, Jones, Robin Russell, Greaves, Malcolm   +4 more
core   +1 more source

BLTR1 in Monocytes Emerges as a Therapeutic Target For Vascular Inflammation With a Subsequent Intimal Hyperplasia in a Murine Wire-Injured Femoral Artery

Frontiers in Immunology, 2018
Given the importance of high-mobility group box 1 (HMGB1) and 5-lipoxygenase (5-LO) signaling in vascular inflammation, we investigated the role of leukotriene signaling in monocytes on monocyte-to-macrophage differentiation (MMD) induced by HMGB1, and ...
Seung E. Baek, Seung E. Baek, So Y. Park, So Y. Park, Sun S. Bae, Sun S. Bae, Koanhoi Kim, Won S. Lee, Chi D. Kim, Chi D. Kim   +9 more
doaj   +1 more source

The Responses of Normal and Psoriatic Skin to Single and Multiple Topical Applications of Leukotriene B4

, 1985
Topical application of single doses of leukotriene B4, (5–500 ng) under occlusion to the skin of normal volunteers and to the clinically normal skin of patients with untreated stable plaque psoriasis caused an inflammatory reaction lasting several days ...
Camp, Richard D., Wong, Elizabeth, Greaves, Malcolm W.   +2 more
core   +1 more source

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Epidermal Cell—Polymorphonuclear Leukocyte Cooperation in the Formation of Leukotriene B4 by Transcellular Biosynthesis

, 1992
The cellular origin of Leukotriene B4, a potent pro nflammatory agent that is present in psoriatic lesions, has not been completely ascertained.
Luis Vila, Josep M de Moragas, Solá, Jesep, Vila, Luis, Puig, Lluis, de Moragas, Josep M, Jesep Solá, Nuria Godessart, Lluis Puig, Godessart, Nuria   +9 more
core   +1 more source

Anti‐inflammatory and cytotoxic properties of kānuka (Kunzea ericoides) subcritical water extract

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Kānuka (Kunzea ericoides) is a medicinal plant native to New Zealand with numerous therapeutic benefits due to its rich bioactive profile. Although several in vitro studies have shown promising anti‐inflammatory activity, substantial evidence elucidating its underlying inflammatory regulatory mechanism and evaluating its cytotoxic ...
Indhuja Devadass, Simon Swift, Saeid Baroutian   +2 more
wiley   +1 more source