Results 51 to 60 of about 18,529 (226)

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Nature Communications, 2018
Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections.
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan   +7 more
doaj   +1 more source

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

The PPARα–leukotriene B4 pathway to inflammation control

, 1996
Inflammation is a local immune response to 'foreign' molecules, infection and injury. Leukotriene B4, a potent chemotactic agent that initiates, coordinates, sustains and amplifies the inflammatory response, is shown to be an activating ligand for the ...
Jeffrey M. Peters, Peters, J.M., Manuel Vazquez, Wahli, W., Keller, H., Vazquez, M., Pallavi R. Devchand, Devchand, P.R., Gonzalez, F.J., Hansjörg Keller, Frank J. Gonzalez, Walter Wahli   +11 more
core   +1 more source

Redox processes are major regulators of leukotriene synthesis in neutrophils exposed to bacteria Salmonella typhimurium; the way to manipulate neutrophil swarming

Frontiers in Immunology
Neutrophils play a primary role in protecting our body from pathogens. When confronted with invading bacteria, neutrophils begin to produce leukotriene B4, a potent chemoattractant that, in cooperation with the primary bacterial chemoattractant fMLP ...
Ekaterina A. Golenkina, Galina M. Viryasova, Svetlana I. Galkina, Natalia D. Kondratenko, Tatjana V. Gaponova, Yulia M. Romanova, Konstantin G. Lyamzaev, Konstantin G. Lyamzaev, Boris V. Chernyak, Galina F. Sud’ina   +9 more
doaj   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes

, 1996
The reactive intermediate formed by 5-lipoxygenase metabolism of arachidonic acid, leukotriene A4, is known to be released from cells and subsequently taken up by other cells for biochemical processing.
R. Muller Peddinghaus, Giancarlo Folco, Angelo Sala, S. Zarini, A. Sala, Manlio Bolla, Reiner Müller-Peddinghaus, G. Folco, M. Bolla, Simona Zarini   +9 more
core   +1 more source

The Role of Leukotriene B4 in Allergic Diseases

Allergology International, 2008
Leukotriene B4 (LTB4) is a lipid mediator with potent chemoattractant properties and that is rapidly generated from activated innate immune cells such as neutrophils, macrophages, and mast cells.
Hiroshi Ohnishi, Nobuaki Miyahara, Erwin W Gelfand   +2 more
doaj   +1 more source

Saliva is one likely source of leukotriene B4 in exhaled breath condensate

, 2006
: Leukotriene (LT)B4 in exhaled breath condensate (EBC) has been reported to be elevated in airway inflammation. The origin of leukotrienes in EBC is, however, not established.
Larsson, K,, Gaber, Flora, Dahlén, Sven-Eric, Palmberg, L,, Sundblad, B-M, I. Delin, Dahlen, S-E, Kumlin, M, Palmberg, Lena, K. Larsson, Delin, I, Sundblad, Britt-Marie, L. Palmberg, Gaber, F, Delin, I,, F. Acevedo, Acevedo, F, Larsson, Kjell, Kumlin, Maria,, B-m. Sundblad, F. Gaber, M. Kumlin   +21 more
core   +1 more source

Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link

The FEBS Journal, EarlyView.
Human RNase 7 is known to exert antimicrobial activity in epithelial tissues. Here, using SH‐SY5Y and U‐87 MG, neuroblastoma and glioblastoma cell lines, respectively, we found that RNase 7 enhances immune responses to LPS stimulation by reducing the expression of pro‐inflammatory cytokines, nitric oxide, and ROS.
Rosanna Culurciello, Maria Cristiano, Ilaria Di Nardo, Ida Palumbo, Erika Piccolo, Rosario Oliva, Andrea Bosso, Aldo Donizetti, Eugenio Notomista, Elio Pizzo   +9 more
wiley   +1 more source

Involvement of Leukotriene B4 in Substance P-Induced Itch-Associated Response in Mice

, 2001
Intradermal injection of substance P elicits an itch sensation in human subjects and an itch-associated response in mice. The substance P-induced itch-associated response in mice is not inhibited by antihistamine. Therefore, the mechanisms of substance P-
Maruyama, Masayuki, Andoh, Tsugunobu, Katsube, Nobuo, Kuraishi, Yasushi   +3 more
core   +1 more source