Results 61 to 70 of about 29,391 (230)

Redox processes are major regulators of leukotriene synthesis in neutrophils exposed to bacteria Salmonella typhimurium; the way to manipulate neutrophil swarming

Frontiers in Immunology
Neutrophils play a primary role in protecting our body from pathogens. When confronted with invading bacteria, neutrophils begin to produce leukotriene B4, a potent chemoattractant that, in cooperation with the primary bacterial chemoattractant fMLP ...
Ekaterina A. Golenkina, Galina M. Viryasova, Svetlana I. Galkina, Natalia D. Kondratenko, Tatjana V. Gaponova, Yulia M. Romanova, Konstantin G. Lyamzaev, Konstantin G. Lyamzaev, Boris V. Chernyak, Galina F. Sud’ina   +9 more
doaj   +1 more source

Phase 2 trial of montelukast for prevention of pain in sickle cell disease. [PDF]

, 2020
Cysteinyl leukotrienes (CysLTs) are lipid mediators of inflammation. In patients with sickle cell disease (SCD), levels of CysLTs are increased compared with controls and associated with a higher rate of hospitalization for pain. We tested the hypothesis
Brandow, Amanda, Bryant, Valencia, DeBaun, Michael R, Embury, Stephen H, Field, Joshua J, Kassim, Adetola, Matsui, Neil, Simpson, Pippa, Wilkerson, Karina, Zhang, Liyun   +9 more
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長期間喫煙による気管支唱息,肺気腫の病態的変化 [PDF]

, 2004
The influence of long-term cigarette smoking on the pathophysiology of chronic respiratory diseases with obstructive ventilatory dysfunction was discussed in patients with asthma and pulmonary emphysema (PE). 1.
Ashida, Kozo, Fujii, Makoto, Hamada, Masanori, Hosaki, Yasuhiro, Iwagaki, Naofumi, Mitsunobu, Fumihiro, Takata, Shingo, Tanizaki, Yoshiro   +7 more
core   +1 more source

Augmentation of 5-lipoxygenase activity and expression during dengue serotype-2 infection [PDF]

, 2013
published_or_final_versio
Chow, AY, Halliwell, B, Lam, KMS, Lee, CYJ, Lim, ECH, Loke, WM, Ooi, EE, Quek, AML, Seet, RCS   +8 more
core   +1 more source

Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link

The FEBS Journal, EarlyView.
Human RNase 7 is known to exert antimicrobial activity in epithelial tissues. Here, using SH‐SY5Y and U‐87 MG, neuroblastoma and glioblastoma cell lines, respectively, we found that RNase 7 enhances immune responses to LPS stimulation by reducing the expression of pro‐inflammatory cytokines, nitric oxide, and ROS.
Rosanna Culurciello, Maria Cristiano, Ilaria Di Nardo, Ida Palumbo, Erika Piccolo, Rosario Oliva, Andrea Bosso, Aldo Donizetti, Eugenio Notomista, Elio Pizzo   +9 more
wiley   +1 more source

Inhaled corticosteroid effects both eosinophilic and non-eosinophilic inflammation in asthmatic patients

Mediators of Inflammation, 2004
AIM: To determine induced sputum cell counts and interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-α) and leukotriene B4 (LTB4) levels as markers of neutrophilic inflammation in moderate persistent asthma, and to evaluate the response to inhaled ...
Ilknur Basyigit, Fusun Yildiz, Sevgiye Kacar Ozkara, Hasim Boyaci, Ahmet Ilgazli   +4 more
doaj   +1 more source

The Role of Leukotriene B4 in Allergic Diseases

Allergology International, 2008
Leukotriene B4 (LTB4) is a lipid mediator with potent chemoattractant properties and that is rapidly generated from activated innate immune cells such as neutrophils, macrophages, and mast cells.
Hiroshi Ohnishi, Nobuaki Miyahara, Erwin W Gelfand   +2 more
doaj   +1 more source

Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma [PDF]

, 2011
Asthma patients who continue to experience symptoms despite being on regular inhaled corticosteroids (ICS) represent a management challenge. Long-acting beta2-agonists (LABA) or anti-leukotrienes (LTRA) are two treatment options that could be considered ...
Adams, Adinoff, Altman, Anonymous, Anonymous, Anonymous, Baraniuk, Barnes, Bateman, Bateman, Becker, Bergmann, Bjermer, Bjermer, Bjermer, Bleecker, Borker, Boulet, Bousquet, Brabson, Buchvald, Buchvald, Buhl, Busse, Caffey, Calhoun, Calhoun, Cash, Cates, Ceylan, Chopra, Chuchalin, Covar, Currie, Currie, Currie, Davies, Davis, Deeks, Dekhuijzen, Delaronde, Dempsey, Deykin, Dicpinigaitis, Donohue, Dorinsky, Dorinsky, Dorinsky, Dorinsky, Ducharme, Ducharme, Ducharme, Ducharme, Dunn, Edelman, Edin, Egger, Eliraz, Eliraz, Ernst, Everden, Fish, Fish, Gabrijelcic, Georgitis, Giannini, Gold, Gold, Green, Green, Green, Grosclaude, Grzelewska-Rzymowska, Gupta, Havlucu, Hendeles, Higgins, Higgins, Horwitz, Houghton, Ilowite, Inoue, Jarvis, Jarvis, Jenkins, Johnson, Jonsson, Kalberg, Kalberg, Kanniess, Kanniess, Karaman, Kardos, Keith, Kemp, Keonig, Kerwin, Knobil, Knorr, Koenig, Kohrogi, Krawiec, Larsen, Laviolette, Lazarus, Lee, Lee, Lee, Lee, Leflein, Leibman, Leibman, Lemanske, Lipworth, Lipworth, Liu, Lotvall, Lougheed, Maspero, Maspero, Maspero, McCarthy, McCarthy, Meltzer, Miraglia del Giudice, Mitchell, Molitor, Naedele-Risha, Nathan, Nathan, Nathan, Nathan, Nathan, Nelson, Nelson, Nelson, Nelson, Nelson, Ni Chroinin, Ni Chroinin, Nsouli, O'Connor, O'Sullivan, Ohbayashi, Ohbayashi, Ollendorf, Oppenheimer, Orgega-Cisneros, Paterson, Pavord, Pearlman, Perera, Perez, Peroni, Peroni, Petermann, Peters, Pieters, Pieters, Plaza, Polos, Powell, Price, Ram, Reddel, Rees, Riccioni, Rickard, Rickard, Ringdal, Ringdal, Rosenhall, Salpeter, Serrier, Sheth, Sims, Sims, Sims, Smith, Sorkness, Stanford, Stelmach, Stelmach, Stelmach, Stelmach, Stelmach, Stelmach, Stempel, Stempel, Stevenson, Storms, Storms, Terzano, Thien, Tolley, Vaquerizo, Volovitz, Walters, Warner, Wasserman, Wenzel, Wilson, Wilson, Wilson, Wytrychowski, Yurdakul, Zarkovic, Zimmerman   +207 more
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1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Novel structural determinants of the human neutrophil chemotactic activity of leukotriene B. [PDF]

, 1981
A specific 5(S),12(R)-dihydroxy-eicosa-6,8,10(trans/trans/cis), 14(cis)-tetraenoic acid, designated leukotriene B, is generated by the lipoxygenation and subsequent enzymatic hydration of arachidonic acid in a variety of leukocytes. Leukotriene B elicits
Goetzl, EJ, Pickett, WC
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