Results 71 to 80 of about 18,529 (226)

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling

Journal of Periodontal Research, EarlyView.
Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon, Sotirios Tetradis, Rolando Vernal, Fabio Renato Manzolli Leite, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Intradermal Nociceptin Elicits Itch-Associated Responses Through Leukotriene B4 in Mice

, 2004
Nociceptin, the endogenous peptide ligand for opioid receptor like-1 (ORL1) receptor, has been implicated in the inflammation and pain in the skin. We examined whether nociceptin is a pruritogen in mice.
Takeshima, Hiroshi, Andoh, Tsugunoubu, Kuraishi, Yasushi, Yageta, Yuichi   +3 more
core   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation

Nature Communications, 2017
HTLV-1 predominantly spreads through direct cell-cell contacts, but mechanisms of target cell recruitment are unclear. Here, the authors show that HTLV-1 infected T-cells secrete leukotriene B4, which recruits T-cells, facilitates HTLV-1 transmissionin ...
Florent Percher, Céline Curis, Eléonore Pérès, Maria Artesi, Nicolas Rosewick, Patricia Jeannin, Antoine Gessain, Olivier Gout, Renaud Mahieux, Pierre-Emmanuel Ceccaldi, Anne Van den Broeke, Madeleine Duc Dodon, Philippe V. Afonso   +12 more
doaj   +1 more source

Inhibition of LTA4H by bestatin in human and mouse colorectal cancerResearch in context

EBioMedicine, 2019
Background: Our preclinical data showed that the leukotriene A4 hydrolase (LTA4H) pathway plays a role in colorectal cancer (CRC). High expression of LTA4H and leukotriene B4 receptor type 1 (BLT1) were also associated with CRC survival probability ...
Simin Zhao, Ke Yao, Dan Li, Kangdong Liu, Guoguo Jin, Mingyang Yan, Qiong Wu, Hanyong Chen, Seung Ho Shin, Ruihua Bai, Gangcheng Wang, Ann M. Bode, Ziming Dong, Zhiping Guo, Zigang Dong   +14 more
doaj   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

The Release of Leukotriene B4-like Material in Biologically Active Amounts from the Lesional Skin of patients with Psoriasis

, 1984
The 5,12-dihydroxy metabolite of arachidonic acid, leukotriene B4, is a highly potent neutrophil chemoattractant. In view of the characteristic epidermal neutrophil infiltrate in psoriasis, the presence of leukotriene B4 in samples from untreated ...
Pauline Dowd, Susan Brain, Richard Camp, Anne Kobza Black, Malcolm Greaves, Brain, Susan, Dowd, Pauline, Camp, Richard, Greaves, Malcolm, Black, Anne Kobza   +9 more
core   +1 more source

Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice

Nature Communications, 2017
Hematopoietic stem and progenitor cells are generated first from the vascular endothelium of the dorsal aorta and then the fetal liver but what regulates this switch is unknown.
Xuan Jiang, John S. Hawkins, Jerry Lee, Carlos O. Lizama, Frank L. Bos, Joan P. Zape, Prajakta Ghatpande, Yongbo Peng, Justin Louie, Giorgio Lagna, Ann C. Zovein, Akiko Hata   +11 more
doaj   +1 more source

Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases

Journal of Lipid Research, 2003
Arachidonic acids (AA) and linoleic acids (LAs) are metabolized, in several tissues, to hydroxylated metabolites that are important mediators of many physiological and pathophysiological processes.
David Turgeon, Sarah Chouinard, Patrick Bélanger, Serge Picard, Jean-François Labbé, Pierre Borgeat, Alain Bélanger   +6 more
doaj   +1 more source

Comparison of leukotriene B4 and D4 effects on human eosinophil and neutrophil motility in vitro

, 1994
The motility of isolated normal human peripheral blood eosinophils and neutrophils in response to exogenous leukotrienes B4 and D4 was examined by means of a modified under-agarose technique and a novel quantitative sampling strategy.
C S Spada, A L Nieves, A H-P Krauss, D F Woodward   +3 more
core   +1 more source