Results 91 to 100 of about 18,529 (226)

Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

Journal of Pharmacological Sciences, 2007
We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation.
Aya Ihara, Koichiro Wada, Masato Yoneda, Nobutaka Fujisawa, Hirokazu Takahashi, Atsushi Nakajima   +5 more
doaj   +1 more source

A Pilot Study: Effects of Dietary Supplementation with α-Linolenic Acid-Enriched Perilla Seed Oil on Bronchial Asthma

Allergology International, 1997
N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in
Kozo Ashida, Fumihiro Mitsunobu, Takashi Mifune, Yasuhiro Hosaki, Satoshi Yokota, Hirofumi Tsugeno, Yoshiro Tanizaki   +6 more
doaj   +1 more source

Leukotriene B4 Induces In Vitro Fibroblast Chemotaxis

, 1984
In vitro fibroblast chemotaxis was studied in the presence of synthetic leukotriene B4 (LTB4) and of supernatants from ionophore-stimulated lymphocytes, monocytes, and basophils (LMB-S).
Mensing, Hartwig, Czarnetzki, Beate M.
core   +1 more source

Synthesis of New Polyunsaturated Fatty Acid Ester of Hydroxyl Fatty Acid (FAHFA): Stearoyl Acid Ester of Leukotriene B4 (LTB4) [PDF]

, 2022
Fatty acid ester of hydroxyl fatty acid (FAHFA) is a molecule family of lipid ester. In recent years,some of them have showed function on anti-inflammation, anti-diabetes.
Ma, Zhichen
core  

Biosynthesis of eicosanoids and transcellular metabolism of leukotrienes in murine bone marrow cells

Journal of Lipid Research, 2007
Leukotriene B4 (LTB4) biosynthesis by polymorphonuclear leukocytes (PMNs) is an important factor of inflammatory responses. PMNs also release LTA4, an unstable intermediate that can be taken up by neighboring cells and metabolized into LTC4. Most studies
Miguel A. Gijón, Simona Zarini, Robert C. Murphy   +2 more
doaj   +1 more source

Epicardial adipose tissue‐linked leukotriene and cytokine signalling pathways – novel targets for prevention of obesity‐ and diabetes‐linked ventricular arrhythmia

The Journal of Physiology, EarlyView.
Kelly A. Aromolaran, Ademuyiwa S. Aromolaran   +1 more
wiley   +1 more source

Signal transduction and activation of the NADPH oxidase in eosinophils

Memorias do Instituto Oswaldo Cruz, 1997
Activation of the eosinophil NADPH oxidase and the subsequent release of toxic oxygen radicals has been implicated in the mechanism of parasite killing and inflammation.
Mark A Lindsay, Mark A Giembycz
doaj   +1 more source

Involvement of leukotriene B4 in TNF-α-induced cytokine expression in human synovial fibroblasts.

, 2014
Human synovial fibroblasts were pretreated with LTB4 receptor antagonist LY29311 (1 µM) for 1 hr, and then treated with TNF-α for another 6 hr. TNF-α-induced up-regulation of IL-6 and MCP-1 were antagonized by LY29311 (A, B).
Yung-Cheng Chiu (630765), Houng-Chi Liou (528937), Rong-Sen Yang (630767), Han-Ching Lin (630762), Ming-Yueh Wu (630764), Wen-Mei Fu (528939), Chih-Hsin Tang (104506), Mann-Jen Hour (163768), Huang-Ju Tu (630766), Tzu-Hung Lin (630763)   +9 more
core   +1 more source

Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats

, 2013
Inflammation within the brain stem microvasculature has been associated with chronic cardiovascular diseases. We found that the expression of several enzymes involved in arachidonic acid-leukotriene B4 (LTB4) production was altered in nucleus tractus ...
Toward, Marie, Hidefumi Waki, David Murphy, Paton, Julian F R, Sabine Gouraud, Murphy, David, Waki, Hidefumi, Sergey Kasparov, Hendy, Emma B, Gouraud, Sabine, Emma B. Hendy, Hindmarch, Charlie C T, Charles C.T. Hindmarch, Marie Toward, Kasparov, Sergey, Julian F.R. Paton   +15 more
core   +1 more source

The effectiveness of unfractionated heparin vs. low molecular weight (Enoxaparin) in Acute Respiratory Distress Syndrom (ARDS) and metabolic dysfunction: an old drug for new indication!

BMC Immunology
Background Acute Respiratory Distress Syndrome is a lung disorder defined by the acute onset of hypoxemia, the commonest being abdominal sepsis.Many biomarkers have been studied for diagnostic prognostication and ARDS pharmacotherapy.
Shabnam Delasoud, Mojtaba Mojtahedzadeh, Mohammad Sharifzadeh, Mohammad Hossein Ghahremani, Abbass Kebriaeezadeh, Maryam Gholami, Samin Sabzevari, Omid Sabzevari   +7 more
doaj   +1 more source