Results 101 to 110 of about 29,391 (230)

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria‐Mediated Intestinal Aging and Barrier Dysfunction

Aging Cell, Volume 25, Issue 5, May 2026.
Environmentally relevant enrofloxacin accelerates intestinal aging by impairing epithelial mitochondrial function, disrupting barrier integrity, and reshaping the gut microbiota. Mitochondrial restoration with pyrroloquinoline quinone alleviates hypoxia, inflammation, and gut damage.
Kan Yu, Nengzheng Wang, Xinyi Huang, Yushu Qiu, Xuejian He, Xiaofeng Zhu, Xiaolan Zhou, Peng Yu, Gang Wei, Yan Pi, Ting Ni   +10 more
wiley   +1 more source

Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. [PDF]

, 1995
Experiments were designed to study the effect of systemically administered IL-5 on local eosinophil accumulation induced by the intradermal injection of the chemokine eotaxin in the guinea pig.
Collins, PD, Griffiths-Johnson, DA, Jose, PJ, Marleau, S, Williams, TJ   +4 more
core   +2 more sources

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

Blockade of Leukotriene B4 Signaling Pathway Induces Apoptosis and Suppresses Cell Proliferation in Colon Cancer

Journal of Pharmacological Sciences, 2007
We investigated whether leukotriene B4 (LTB4) and its signaling pathway play an important role in the progression of human colon cancer via a direct stimulation of cancer cell proliferation.
Aya Ihara, Koichiro Wada, Masato Yoneda, Nobutaka Fujisawa, Hirokazu Takahashi, Atsushi Nakajima   +5 more
doaj   +1 more source

Pharmacokinetics and Anti‐Inflammatory Effects of Intramuscular Betamethasone in Exercised Thoroughbred Horses

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 3, Page 295-305, May 2026.
ABSTRACT The pharmacokinetics and pharmacodynamics of betamethasone following intra‐articular administration to horses have been described; however, studies characterizing intramuscular administration are lacking. Twenty‐four horses received an intramuscular dose of 12 mg betamethasone sodium phosphate/betamethasone acetate.
Juliana Sullivan, Jeff Blea, Daniel S. McKemie, Philip H. Kass, Heather K. Knych   +4 more
wiley   +1 more source

A Pilot Study: Effects of Dietary Supplementation with α-Linolenic Acid-Enriched Perilla Seed Oil on Bronchial Asthma

Allergology International, 1997
N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma. The effects of dietary supplementation with perilla seed oil rich in a-linolenic acid (α-LNA), parent n-3 fatty acid, were studied in
Kozo Ashida, Fumihiro Mitsunobu, Takashi Mifune, Yasuhiro Hosaki, Satoshi Yokota, Hirofumi Tsugeno, Yoshiro Tanizaki   +6 more
doaj   +1 more source

Biosynthesis of eicosanoids and transcellular metabolism of leukotrienes in murine bone marrow cells

Journal of Lipid Research, 2007
Leukotriene B4 (LTB4) biosynthesis by polymorphonuclear leukocytes (PMNs) is an important factor of inflammatory responses. PMNs also release LTA4, an unstable intermediate that can be taken up by neighboring cells and metabolized into LTC4. Most studies
Miguel A. Gijón, Simona Zarini, Robert C. Murphy   +2 more
doaj   +1 more source

The effectiveness of unfractionated heparin vs. low molecular weight (Enoxaparin) in Acute Respiratory Distress Syndrom (ARDS) and metabolic dysfunction: an old drug for new indication!

BMC Immunology
Background Acute Respiratory Distress Syndrome is a lung disorder defined by the acute onset of hypoxemia, the commonest being abdominal sepsis.Many biomarkers have been studied for diagnostic prognostication and ARDS pharmacotherapy.
Shabnam Delasoud, Mojtaba Mojtahedzadeh, Mohammad Sharifzadeh, Mohammad Hossein Ghahremani, Abbass Kebriaeezadeh, Maryam Gholami, Samin Sabzevari, Omid Sabzevari   +7 more
doaj   +1 more source

Signal transduction and activation of the NADPH oxidase in eosinophils

Memorias do Instituto Oswaldo Cruz, 1997
Activation of the eosinophil NADPH oxidase and the subsequent release of toxic oxygen radicals has been implicated in the mechanism of parasite killing and inflammation.
Mark A Lindsay, Mark A Giembycz
doaj   +1 more source

Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins [PDF]

, 2017
Atherogenesis is an inflammatory process with leukocytes infiltrating the arterial intima. The lipoxygenase pathways play a role in leukocyte recruitment through the generation of two classes of arachidonic acid lipid mediators, the leukotrienes and the ...
Hersberger, Martin
core