Results 1 to 10 of about 53,318 (217)

Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes. [PDF]

PLoS ONE, 2013
Leukotriene E4 (LTE4), the most stable of the cysteinyl leukotrienes (cysLTs), binds poorly to classical type 1 and 2 cysLT receptors although in asthmatic individuals it may potently induce bronchial constriction, airway hyperresponsiveness and ...
Holly R Foster, Elisabeth Fuerst, Tak H Lee, Davis J Cousins, Grzegorz Woszczek   +4 more
doaj   +10 more sources

Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases [PDF]

Mediators of Inflammation, 2017
Cysteinyl leukotrienes (CysLTs) are potent lipid mediators widely known for their actions in asthma and in allergic rhinitis. Accumulating data highlights their involvement in a broader range of inflammation-associated diseases such as cancer, atopic ...
Paolo Gelosa, Francesca Colazzo, Elena Tremoli, Luigi Sironi, Laura Castiglioni   +4 more
doaj   +5 more sources

Cysteinyl Leukotrienes in Allergic Inflammation. [PDF]

Annu Rev Pathol
The cysteinyl leukotrienes (CysLTs), LTC4, LTD4, and LTE4, are potent lipid mediators derived from arachidonic acid through the 5-lipoxygenase pathway.
Lee M, Boyce JA, Barrett NA.
europepmc   +4 more sources

Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases [PDF]

Mediators of Inflammation, 2017
Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore ...
Francesca Colazzo, Paolo Gelosa, Elena Tremoli, Luigi Sironi, Laura Castiglioni   +4 more
doaj   +3 more sources

Cysteinyl Leukotrienes in Eosinophil Biology: Functional Roles and Therapeutic Perspectives in Eosinophilic Disorders [PDF]

Frontiers in Medicine, 2017
Cysteinyl leukotrienes (cysLTs), LTC4, and its extracellular metabolites, LTD4 and LTE4, have varied and multiple roles in mediating eosinophilic disorders including host defense against parasitic helminthes and allergic inflammation, especially in the ...
Glaucia A. Thompson-Souza, Isabella Gropillo, Josiane S. Neves   +2 more
doaj   +3 more sources

Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation. [PDF]

Sci Immunol, 2021
Aeroallergen sensing by airway epithelial cells can trigger pathogenic immune responses leading to chronic type 2 inflammation, the hallmark of airway diseases such as asthma.
Ualiyeva S, Lemire E, Aviles EC, Wong C, Boyd AA, Lai J, Liu T, Matsumoto I, Barrett NA, Boyce JA, Haber AL, Bankova LG.   +11 more
europepmc   +2 more sources

Cysteinyl-leukotrienes promote cutaneous Leishmaniasis control [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
Leishmaniasis is a neglected tropical parasitic disease with few approved medications. Cutaneous leishmaniasis (CL) is the most frequent form, responsible for 0.7 - 1.0 million new cases annually worldwide.
Letícia Paula Trajano Noronha, Monique Daiane Andrade Martins, Archimedes Barbosa Castro-Junior, Maria Luiza Thorstenberg, Laís Costa-Soares, Thuany Prado Rangel, Felipe Carvalho-Gondim, Bartira Rossi-Bergmann, Luiz Eduardo Baggio Savio, Claudio de Azevedo Canetti, Robson Coutinho-Silva   +10 more
doaj   +2 more sources

Cysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders [PDF]

CNS Neuroscience and Therapeutics, 2016
Arijit Ghosh, Abhimanyu Thakur, Hao Hong
exaly   +3 more sources

Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2. [PDF]

Sci Immunol, 2020
Aeroallergens and ATP elicit cysteinyl leukotrienes from nasal brush cells through the purinergic receptor P2Y2. Nasal sensors of danger The epithelium of the nasal mucosa includes specialized chemosensory cells in the brush/tuft cell family that use ...
Ualiyeva S, Hallen N, Kanaoka Y, Ledderose C, Matsumoto I, Junger WG, Barrett NA, Bankova LG.   +7 more
europepmc   +2 more sources

Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice. [PDF]

Science
Food-specific IgE triggers life-threatening anaphylaxis; however, for unclear reasons, some people with food-specific IgE are asymptomatic upon allergen consumption.
Hoyt LR, Liu E, Olson EC, Jacobsen DR, Siniscalco ER, Krier-Burris RA, Greenfield KG, McBride CD, Alfajaro MM, Amat JAR, Zhao Z, Xu L, Philip V, Verma A, Fourati S, Senger DL, Zhang L, Bunyavanich S, Glass SE, Coffey RJ, Wilen CB, Williams A, Eisenbarth SC.   +22 more
europepmc   +2 more sources