Results 41 to 50 of about 53,318 (217)

Basophils from allergy to cancer

Frontiers in Immunology, 2022
Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating leukocytes. While this scarcity long hampered basophil studies, innovations during the past 30 years, beginning with their isolation and more recently in the ...
Remo Poto, Remo Poto, Remo Poto, Adriana Rosa Gambardella, Adriana Rosa Gambardella, Gianni Marone, Gianni Marone, Gianni Marone, Gianni Marone, John T. Schroeder, Fabrizio Mattei, Giovanna Schiavoni, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi   +15 more
doaj   +1 more source

Synthesis and metabolism of cysteinyl leukotrienes by the isolated pig kidney [PDF]

, 1992
Synthesis and metabolism of cysteinyl leukotrienes by the isolated pig kidney. The metabolism and synthesis of cysteinyl leukotrienes by the isolated perfused pig kidney has been investigated.
Tan, Kai-Chah, Moore, Kevin P., Gove, Christopher, Wood, John, Williams, Roger, Eason, John, Taylor, Graham W.   +6 more
core   +1 more source

Human bronchial fibroblasts express the 5-lipoxygenase pathway

Respiratory Research, 2006
Background Fibroblasts are implicated in sub-epithelial fibrosis in remodeled asthmatic airways and contribute to airway inflammation by releasing cytokines and other mediators.
Holgate Stephen T, Cazaly Angelica M, Penrose John F, James Anna J, Sampson Anthony P   +4 more
doaj   +1 more source

Koboku An Extract of Magnolia Bark, Inhibits Leukotriene Synthesis in Rat Basophilic Leukemia-1 Cells

Allergology International, 1997
To determine anti-allergic effects of Koboku, a Chinese herbal medicine, we investigated its inhibitory action on the production of cysteinyl leukotrienes (LT) and LTB4, which are important chemical mediators in the pathogenesis of allergic diseases ...
Yuhei Hamasaki, Ikuko Kobayashi, Michiko Kita, Rika Hayasaki, Masafumi Zaitu, Eriko Muro, Shuichi Yamamoto, Muneaki Matsuo, Tomohiro Ichimaru, Sumio Miyazaki   +9 more
doaj   +1 more source

The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing.

Clinical Immunology, 2017
To analyze the participation of the enzyme 5-lipoxygenase (5-LO) in skin repair, WT wounds were compared to those in 5-LO deficient mice (5-LO-/-), which presented faster closure and reduced inflammatory infiltrate in the skin, together with increased ...
F. R. Guimaraes, Helioswilton Sales-Campos, Viviani Nardini, Thiago Álvares da Costa, M. T. Fonseca, Virmondes Rodrigues, C. Sorgi, J. S. da Silva, J. E. L. Chica, L. Faccioli, C. R. de Barros Cardoso   +10 more
semanticscholar   +1 more source

The role of leukotrienes in the pathogenesis of systemic sclerosis

Folia Histochemica et Cytobiologica, 2012
Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by widespread vascular injury and progressive fibrosis of the skin and internal organs.
Sylwia Chwieśko-Minarowska, Krzysztof Kowal, Marek Bielecki, Otylia Kowal-Bielecka   +3 more
doaj   +1 more source

Is GPR17 a P2Y/Leukotriene Receptor? Examination of Uracil Nucleotides, Nucleotide Sugars, and Cysteinyl Leukotrienes as Agonists of GPR17 [PDF]

Journal of Pharmacology and Experimental Therapeutics, 2013
The orphan receptor GPR17 has been reported to be activated by UDP, UDP-sugars, and cysteinyl leukotrienes, and coupled to intracellular Ca2+ mobilization and inhibition of cAMP accumulation, but other studies have reported either a different agonist ...
Aidong Qi, T. K. Harden, R. Nicholas
semanticscholar   +2 more sources

Is There a Role for Basophils in Cancer?

Frontiers in Immunology, 2020
Basophils were identified in human peripheral blood by Paul Ehrlich over 140 years ago. Human basophils represent <1% of peripheral blood leukocytes.
Giancarlo Marone, Giancarlo Marone, John T. Schroeder, Fabrizio Mattei, Stefania Loffredo, Stefania Loffredo, Stefania Loffredo, Stefania Loffredo, Adriana Rosa Gambardella, Remo Poto, Remo Poto, Amato de Paulis, Amato de Paulis, Amato de Paulis, Giovanna Schiavoni, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi   +18 more
doaj   +1 more source

Role of Leukotrienes and Leukotriene Modifiers in Asthma

Pharmaceuticals, 2010
Leukotrienes (LTs), including cysteinyl LTs (CysLTs) and LTB4, are potent lipid mediators that are pivotal in the pathophysiology of asthma phenotypes. At least two receptor subtypes for CysLTs – CysLT1 and CysLT2 – have been identified.
Paolo Montuschi
doaj   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source