Results 61 to 70 of about 53,318 (217)

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Leukotrienes vs. Montelukast—Activity, Metabolism, and Toxicity Hints for Repurposing

Pharmaceuticals, 2022
Increasing environmental distress is associated with a growing asthma incidence; no treatments are available but montelukast (MTK)—an antagonist of the cysteinyl leukotrienes receptor 1—is widely used in the management of symptoms among adults and ...
Cátia F. Marques, M. Marques, Gonçalo C. Justino   +2 more
semanticscholar   +1 more source

Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules

, 2017
Background—Cysteinyl leukotrienes are recognized to act via receptors (CysLTRs) expressed on cell surface plasma membranes. Agents that block CysLT1R, are therapeutics for allergic disorders.
Weller, Peter, Neves, Josiane S., Radke, Amy L.   +2 more
core   +1 more source

Montelukast Versus Gabapentin for Uremic Pruritus in Twice‐Weekly Hemodialysis Patients: A 52‐Week Prospective Non‐Randomized Open‐Label Comparative Study

Hemodialysis International, EarlyView.
ABSTRACT Background Uremic pruritus (UP) remains a common and distressing complication in patients with end‐stage renal disease (ESRD) receiving maintenance hemodialysis. The burden is particularly pronounced in low‐ and middle‐income countries where twice‐weekly hemodialysis is frequently practiced because of resource limitations. Gabapentin is widely
Bilal Mohsin, Muhammad Ahmad, Irfan Rasool, Nouf Alotaibi, Wahaj Mirajullah, Imran Khan, Sara Faisal, Khalid Abdulrazek, Aziz Mengal, Saima Faisal   +9 more
wiley   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Increased expression of leukotriene C ₄ synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm

, 2010
Leukotrienes (LTs) are arachidonic acid-derived lipid mediators involved in the pathogenesis and progression of diverse inflammatory disorders.
Antonio Di Gennaro, Wågsäter, Dick,, Häggström, Jesper,, Jesper Z. Haeggström, Hamsten, Anders,, Eriksson, Per,, Per Eriksson, Gabrielsen, Anders,, Anders Gabrielsen, Swedenborg, Jesper,, Di Gennaro, Antonio,, Jesper Swedenborg, Mikko I. Mäyränpää, Mäyranpää, Mikko,, Bengt Samuelsson, Dick Wågsäter, Anders Hamsten, Samuelsson, Bengt,   +17 more
core   +1 more source

ROLE OF ANTILEUKOTRIENE DRUGS IN ACHIEVEMENT OF BRONCHIAL ASTHMA CONTROL

Медицинский совет, 2017
Bronchial asthma (BA) is a common chronic disease heterogeneous in nature and variable in its course. Heterogeneity in asthma is manifested in relation to the age of the onset, triggers, pattern of inflammation, severity of clinical manifestations and ...
N. M. Nenasheva
doaj   +1 more source

Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease. [PDF]

PLoS ONE, 2012
BACKGROUND: Serine proteases promote inflammation and tissue remodeling by activating proteinase-activated receptors, urokinase, metalloproteinases and angiotensin. In the present study, 4-(2-Aminoethyl) benzenesulfonyl fluoride (AEBSF) a serine protease
Sanjay Saw, Sagar Laxman Kale, Naveen Arora   +2 more
doaj   +1 more source

Tuft cell-derived leukotrienes drive rapid anti-helminth immunity in the small intestine but are dispensable for anti-protist immunity

Immunity, 2020
SUMMARY Helminths, allergens, and certain protists induce type 2 immune responses, but the underlying mechanisms of immune activation remain poorly understood. In the small intestine, chemosensing by epithelial tuft cells results in activation of group 2
John W. McGinty, Hung-An Ting, Tyler E. Billipp, Marija S. Nadjsombati, D. M. Khan, N. Barrett, Hong-Erh Liang, I. Matsumoto, J. von Moltke   +8 more
semanticscholar   +1 more source

Mast Cells in Host Defense Against Cutaneous Staphylococcus aureus Infection

Immunology &Cell Biology, Volume 104, Issue 9, Page 867-880, October 2026.
Impact of S. aureus epicutaneous sensitization models on mast cell function in vivo. D. farinae and Staphylococcal enterotoxin B (SEB) activate Trpv1+ Tac1+ nociceptors to trigger the release of substance P (SP), which promotes mast cell degranulation through Mrgprb2. S.
Hannah Dychtenberg, Carly Kadonoff, Bailey Lehnert, Priyanka Pundir   +3 more
wiley   +1 more source