Results 71 to 80 of about 53,318 (217)

Hyperleukotrieneuria in Patients with Allergic and Inflammatory Disease

Allergology International, 2008
Cysteinyl leukotrienes (CysLTs: leukotrienes C4, D4, and E4) have long been implicated in the pathogenesis of asthma and several allergic diseases. LTE4 has been identified as a major metabolite of LTC4, and urinary LTE4 (U-LTE4) is considered as the ...
Masami Taniguchi, Noritaka Higashi, Emiko Ono, Haruhisa Mita, Kazuo Akiyama   +4 more
doaj   +1 more source

The Role of Immunoresolvents in Atherosclerosis: A Mini‐Review on Their Biology and Therapeutic Opportunities

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Atherosclerosis is a lipid‐induced chronic inflammatory cardiovascular disorder denoted by the infiltration of immune cells and the agglomeration of lipids in the intima, the innermost layer, of the arteries of large and medium sizes.
Ramin Lotfi, Alireza Nasirifar, Hoda Rahmani, Sara Falahi, Meysam Kashiri   +4 more
wiley   +1 more source

Role of Cysteinyl Leukotrienes in Food Allergy and Anaphylaxis: A Potential Therapeutic Target

Allergy, EarlyView.
Adrienn Weingärtner, Thomas Eiwegger
wiley   +1 more source

Beyond Histamine: Mast Cell‐Neuron Communication in Chronic Pruritic and Pain Disorders

Experimental Dermatology, Volume 35, Issue 8, August 2026.
ABSTRACT Chronic pruritic and cutaneous pain disorders are increasingly recognized as neuroimmune conditions driven by dynamic interactions between immune and sensory systems. While histamine has historically dominated models of mast cell‐mediated itch, accumulating evidence indicates that non‐histaminergic pathways are central to chronic disease.
Tomer Kagan, Gil Yosipovitch
wiley   +1 more source

Intercellular Ca2+ wave propagation involving positive feedback between CRAC channels and cysteinyl leukotrienes.

, 2009
Mast cells are key components of the immune system, where they help orchestrate the inflammatory response. Aberrant mast cell activation is linked to a variety of allergic diseases, including asthma, eczema, rhinitis, and nasal polyposis, which in ...
Bates, G, Parekh, AB, Parekh, Anant, Shirley, A, Di Capite, J, Nelson, C   +5 more
core   +1 more source

Paucigranulocytic Asthma in Aspirin‐Hypersensitive Patients: Pleiotropic Regulation of Type 2 Biomarkers

Clinical and Translational Allergy, Volume 16, Issue 7, July 2026.
Two clusters were identified among N‐ERD patients with a paucigranulocytic airway inflammatory phenotype. Cluster 1N‐ERD showed milder asthma but higher blood eosinophil counts, more severe sinonasal disease, and elevated LTE4 levels in induced sputum supernatant. Severe sinonasal disease and elevated local LTE4 may indicate type 2 inflammation despite
Radosław Kacorzyk, Piotr Szatkowski, Agnieszka Gawlewicz‐Mroczka, Adam Ćmiel, Anna Gielicz, Adam Stępień, Patryk Hartwich, Marek Sanak, Lucyna Mastalerz   +8 more
wiley   +1 more source

Cysteine leukotrienes as key mediators of immune-dependent diseases and the therapeutic potential of the leukotriene receptor antagonist (montelukast). Part 2

Лечащий Врач
Background. Cysteine leukotrienes are lipid mediators formed upon activation of the 5-lipoxygenase pathway of arachidonate metabolism. These are universal mediators with a wide spectrum of action, affecting almost all aspects of mammalian biology.
N. G. Astafieva, I. E. Mikhailova, E. O. Gaisina, I. A. Perfilova, E. N. Udovichenko   +4 more
doaj   +1 more source

Montelukast: The New Therapeutic Option for the Treatment of Epilepsy

Journal of Experimental Pharmacology, 2021
Bekalu Amare Tesfaye, Haftom Gebregergs Hailu, Kaleab Alemayehu Zewdie, Muluken Altaye Ayza, Derbew Fikadu Berhe Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Haftom Gebregergs Hailu ...
Tesfaye BA, Hailu HG, Zewdie KA, Ayza MA, Berhe DF   +4 more
doaj  

Pathogenesis of NSAID-induced reactions in aspirin-exacerbated respiratory disease

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2018
It is well-established that following ingestion of aspirin or any other inhibitor of cyclooxygenase-1, patients with Samter's disease, or aspirin-exacerbated respiratory disease (AERD) develop the sudden onset of worsening respiratory clinical symptoms ...
Tanya M. Laidlaw
doaj   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source