Results 81 to 90 of about 53,318 (217)

Cysteinyl leukotrienes mediate enhanced vasoconstriction to angiotensin II but not endothelin-1 in SHR

, 2001
We assessed whether cysteinyl leukotrienes mediate the vasoconstrictor responses to angiotensin II and endothelin-1 in the mesenteric vascular bed of Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) perfused ex vivo at a constant flow rate of
J. Robert McNeill, Venkat Gopalakrishnan, Shailesh Shastri, Thomas W. Wilson, Chamanlal Kaul, Ramarao Poduri   +5 more
core   +1 more source

Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle

, 2001
Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors have been cloned, CysLT, and CysLT2.
Magnus Bäck (378257)
core   +1 more source

Influenza‐induced tuft cell expansion is associated with changes in ILC2 populations in the distal lungs of mice

Physiological Reports, Volume 14, Issue 13, July 2026.
Abstract Tuft cells act as sentinels that amplify type 2 inflammation primarily by activating type 2 innate lymphoid cells (ILC2s). Although normally absent from the distal lung, ectopic tuft cells form after severe lung injury including influenza infection in mice.
Maria Elena Gentile, Michael M. Maiden, Evelyn A. Martinez, Madeline Singh, Harshini Kelam, Nicolas P. Holcomb, Meryl Mendoza, Joanna Wong, Diana M. Abraham, Alena Klochkova, Sara Kass‐Gergi, Andrew E. Vaughan   +11 more
wiley   +1 more source

Concentrations of Cysteinyl Leukotrienes in Various Biological Fluids of Children with Bronchial Asthma, Atopic Dermatitis and Food Protein Induced Enterocolitis [PDF]

, 2019
Clinical manifestation of food allergy is characterized by polymorphic cutaneous, respiratory and gastrointestinal syndromes. Leukotrienes occupy a key place in the pathogenesis of a wide range of inflammatory diseases, including bronchial asthma ...
Haiduchyk, H. (Halyna), Shadrin, O. (Oleg), Halyna Haiduchyk, Oleg Shadrin, Haiduchyk, Halyna, Shadrin, Oleg   +5 more
core   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Intestinal mast cell-derived leukotrienes mediate anaphylactic response to ingested antigens

Science
Anaphylaxis is a life-threatening complication of food allergen exposure. While mechanisms governing anaphylaxis after intravenous injection are defined in mice, these models neglect mucosal exposure that accompanies ingestion.
Nathaniel D Bachtel, Jaime L Cullen, Min Liu, S. Erickson, V. Kutyavin, Darine W El-Naccache, E. Florsheim, Jaechul Lim, Zuri A. Sullivan, Raiden Imaeda, Andrew Hudak, Cuiling Zhang, R. Medzhitov   +12 more
semanticscholar   +1 more source

Cysteine leukotrienes as key mediators of immune-dependent diseases and the therapeutic potential of the leukotriene receptor antagonist (montelukast). Part 1

Лечащий Врач
Background. Cysteine leukotrienes are lipid mediators formed upon activation of the 5-lipoxygenase pathway of arachidonate metabolism. These are universal mediators with a wide spectrum of action, affecting almost all aspects of mammalian biology.
N. G. Astafieva, I. E. Mikhailova, E. O. Gaisina, I. A. Perfilova, E. N. Udovichenko   +4 more
doaj   +1 more source

Circulatory leukotriene changes during bone healing following osteotomies prepared with Er:YAG laser and piezosurgery: an animal study

Biotechnology & Biotechnological Equipment, 2019
Among high-energy lasers, the short-pulsed infrared erbium-doped yttrium aluminium garnet (Er:YAG) laser has shown the best potential for precise cutting and rapid osseous healing. The objective of the present study was to analyse the healing of the bone
Nikola Hadzi-Petrushev, Elizabeta Gjorgievska, Dragana Gabric, Sorina Dinescu, Vadim Mitrokhin, Mitko Mladenov   +5 more
doaj   +1 more source

A role for inflammatory mediators in heterologous desensitization of CysLT1 receptor in human monocytes

Journal of Lipid Research, 2010
Cysteinyl-leukotrienes (cysteinyl-LT) are rapidly generated at sites of inflammation and, in addition to their role in asthma, rhinitis, and other immune disorders, are increasingly regarded as significant inflammatory factors in cancer, gastrointestinal,
Valérie Capra, Maria Rosa Accomazzo, Fabrizio Gardoni, Silvia Barbieri, G. Enrico Rovati   +4 more
doaj   +1 more source

Nasal Blockage Induced by Oral Administration of Non-steroidal Anti-inflammatory Drugs in a Guinea-Pig Model of Allergic Rhinitis

Journal of Pharmacological Sciences, 2007
To elucidate the mechanisms underlying nasal symptoms in patients with aspirin hypersensitivity, we evaluated the effects of orally administered non-steroidal anti-inflammatory drugs (NSAIDs) on the nasal patency of guinea pigs with cedar pollen–induced ...
Hai Yan Han, Takeshi Nabe, Nobuaki Mizutani, Masanori Fujii, Tetsuya Terada, Hiroshi Takenaka, Shigekatsu Kohno   +6 more
doaj   +1 more source