Results 101 to 110 of about 53,318 (217)

Assay of Leukotrienes

, 1983
The leukotrienes and the related hydroxy acids constitute a chemically and biologically rather heterogenous group of compounds. Thus, the assay methods employed for their detection and quantification by necessity differ considerably, depending on what ...
Hansson, G, G. Hansson, S.-E. Dahlén, Granström, E, E. Granström, Dahlén, S-E   +5 more
core   +1 more source

Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and putative therapeutic targets in COVID-19 patients. [PDF]

Inflamm Res, 2023
Reina-Couto M, Roboredo-Madeira M, Pereira-Terra P, Silva-Pereira C, Martins S, Teixeira-Santos L, Pinho D, Dias A, Cordeiro G, Dias CC, Sarmento A, Tavares M, Guimarães JT, Roncon-Albuquerque R, Paiva JA, Albino-Teixeira A, Sousa T.   +16 more
europepmc   +1 more source

Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules

Journal of Allergy and Clinical Immunology, 2010
Background Cysteinyl leukotrienes are recognized to act via receptors (CysLTRs) expressed on cell surface plasma membranes. Agents that block CysLT1R, are therapeutics for allergic disorders.
J. Neves, Amy L. Radke, P. Weller
semanticscholar   +1 more source

Urinary Cysteinyl Leukotrienes as Biomarkers of Endothelial Activation, Inflammation and Oxidative Stress and Their Relationship with Organ Dysfunction in Human Septic Shock. [PDF]

Biomedicines, 2022
Reina-Couto M, Santos-Oliveira M, Pereira-Terra P, Silva-Pereira C, Quelhas-Santos J, Duarte Á, Martins S, Serrão P, Dias CC, Morato M, Guimarães JT, Roncon-Albuquerque R, Paiva JA, Albino-Teixeira A, Sousa T.   +14 more
europepmc   +1 more source

Nicotine Inhibits FcεRI-induced Cysteinyl Leukotrienes and Cytokine Production without Affecting Mast Cell Degranulation Through Alpha7/Alpha9/Alpha10-nicotinic Receptors

Journal of Immunology, 2010
Smokers are less likely to develop some inflammatory and allergic diseases. In Brown-Norway rats, nicotine inhibits several parameters of allergic asthma, including the production of Th2 cytokines and the cysteinyl leukotriene LTC4.
N. Mishra, Jules Rir-sima-ah, R. Boyd, S. Singh, Sravanthi Gundavarapu, R. Langley, S. Razani-Boroujerdi, M. Sopori   +7 more
semanticscholar   +1 more source

P2Y ₁ and Cysteinyl Leukotriene Receptors Mediate Purine and Cysteinyl Leukotriene Co-Release in Primary Cultures of Rat Microglia

International Journal of Immunopathology and Pharmacology, 2005
Inflammation is widely recognized as contributing to the pathology of acute and chronic neurodegenerative conditions. Microglial cells are pathologic sensors in the brain and activated microglia have been viewed as detrimental. Leukotriene, including cysteinyl leukotrienes (CysLTs) are suggested to be involved in brain inflammation
BALLERINI, Patrizia, DI IORIO, Patrizia, CICCARELLI, Renata, CACIAGLI, Francesco, POLI A, BERAUDI A, BUCCELLA, SILVANA, D'ALIMONTE, Iolanda, D'AURO, MARIAGRAZIA, NARGI, Eleonora, PATRICELLI, Paola, VISINI, DANIELA, TRAVERSA U.   +12 more
openaire   +5 more sources

Cysteinyl leukotrienes enhance growth of human airway epithelial cells

, 1990
Epithelial inflammation may play an obligatory role in the pathogenesis of a number of chronic pulmonary diseases such as asthma or bronchitis and has been implicated during the promotion phase of multistage carcinogenesis.
R. C. Grafstrom, G. D. Leikauf, S. Hybbinette, C. A. Doupnik, H. E. Claesson   +4 more
core   +1 more source

Molecular insights into ago-allosteric modulation at cysteinyl leukotriene receptor 2

Nature Communications
Cysteinyl leukotriene receptor CysLT2R, which is activated by the endogenous cysteinyl leukotrienes (CysLTs) LTC4, LTD4, and LTE4, has emerged as a potential therapeutic target due to the involvement in various inflammatory diseases.
Mu Li, Xiaoling Bao, Wanbiao Chen, Yusheng Guo, Xiaomin Mao, Miaofang Xiao, Siqi Liu, Jiawei Li, Limin Zhao, Tiancai Chang, Fumei Zhong, Chongyuan Wang, Heng Liu   +12 more
doaj   +1 more source

Montelukast, an Antagonist of Cysteinyl Leukotriene Signaling, Impairs Burn Wound Healing. [PDF]

Plast Reconstr Surg, 2022
Nguyen AV, Bagood MD, Wang M, Caryotakis SE, Smith G, Yee S, Shen H, Isseroff RR, Soulika AM.   +8 more
europepmc   +1 more source

Enhanced Cysteinyl-Leukotriene Type 1 Receptor Expression in T Cells from House Dust Mite-Allergic Individuals following Stimulation with Der p

Journal of Immunology Research, 2015
In order to determine the potential for allergen to modulate T cell expression of the CysLT1 receptor and responsiveness to leukotrienes, peripheral blood mononuclear cells from house dust mite-allergic or nonallergic individuals were incubated with D ...
Maryse Thivierge, Sylvie Turcotte, Marek Rola-Pleszczynski, Jana Stankova   +3 more
doaj   +1 more source