Cysteinyl leukotrienes and their receptors; emerging concepts. [PDF]
Allergy Asthma Immunol Res, 2014 Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway.
Kanaoka Y, Boyce JA.
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Adipokines and Cysteinyl Leukotrienes in the Pathogenesis of Asthma. [PDF]
J Allergy (Cairo), 2015 Background. The prevalence of obesity has increased dramatically over the last decades, and its association with asthma is being increasingly recognized. Aims.
Coffey MJ, Torretti B, Mancuso P.
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Cysteinyl leukotrienes and their receptors: bridging inflammation and colorectal cancer. [PDF]
World J Gastroenterol, 2014 Long-standing inflammation has emerged as a hallmark of neoplastic transformation of epithelial cells and may be a limiting factor of successful conventional tumor therapies. A complex milieu composed of distinct stromal and immune cells, soluble factors
Savari S +3 more
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Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. [PDF]
Anesthesiology, 2011 Background: Sepsis impairs hypoxic pulmonary vasoconstriction (HPV) in patients and animal models, contributing to systemic hypoxemia. Concentrations of cysteinyl leukotrienes are increased in the bronchoalveolar lavage fluid of patients with sepsis, but
Petersen B +6 more
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Prostaglandin E2 in NSAID-exacerbated respiratory disease: protection against cysteinyl leukotrienes and group 2 innate lymphoid cells. [PDF]
Curr Opin Allergy Clin Immunol, 2019 Purpose of review The purpose of this review is to describe the recent advances that have been made in understanding the protective role of prostaglandin E2 (PGE2) in aspirin-exacerbated respiratory disease (AERD), known in Europe as NSAID-exacerbated ...
Rusznak M, Peebles RS.
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Cysteinyl leukotrienes as novel host factors facilitating Cryptococcus neoformans penetration into the brain. [PDF]
Cell Microbiol, 2017 Cryptococcus neoformas infection of the central nervous system (CNS) continues to be an important cause of mortality and morbidity, and a major contributing factor is our incomplete knowledge of the pathogenesis of this disease.
Zhu L +4 more
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Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. [PDF]
Front Pharmacol, 2016 Genetic variants associated with asthma pathogenesis and altered response to drug therapy are discussed. Many studies implicate polymorphisms in genes encoding the enzymes responsible for leukotriene synthesis and intracellular signaling through ...
Thompson MD +6 more
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Unraveling cysteinyl leukotrienes and their receptors in inflammation through the brain-gut-lung axis [PDF]
VirulenceCysteinyl leukotrienes (CysLTs), as potent lipid inflammatory mediators, play a pivotal role in systemic multi-organ inflammation and inter-organ communication through interactions with their receptors (CysLTRs). However, However, the function of CysLT3R
Xiao-Ru Liu +7 more
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Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT₂ and CysLT₁ receptors. [PDF]
Sci Rep, 2013 Cysteinyl leukotrienes (cys-LTs), LTC4, LTD4, LTE4 are potent inflammatory lipid mediators that act through two distinct G-protein-coupled receptors, CysLT1R and CysLT2R.
Duah E +6 more
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Integrated Immune, Epithelial and Lipid Pathways in NSAID-Exacerbated Respiratory Disease. [PDF]
Clin Transl AllergyABSTRACT NSAID‐exacerbated respiratory disease (N‐ERD) is a chronic inflammatory disorder characterized by asthma, chronic rhinosinusitis with nasal polyps and respiratory reactions to cyclooxygenase‐1 inhibiting nonsteroidal anti‐inflammatory drugs (NSAID).
Szatkowski P, Mastalerz L.
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