Results 21 to 30 of about 24,435,752 (203)

Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors [PDF]

Genomics & Informatics, 2017
We have previously reported that NS-398, a cyclooxygenase-2 (COX-2)–selective inhibitor, inhibited replicative cellular senescence in human dermal fibroblasts and skin aging in hairless mice. In contrast, celecoxib, another COX-2–selective inhibitor, and
Jeong A. Han, Jong-Il Kim
doaj   +1 more source

Triterpenoid and Coumarin Isolated from Astilbe grandis with Anti-Inflammatory Effects through Inhibiting the NF-κB Pathway in LPS-Induced RAW264.7 Cells

Molecules, 2023
The roots of Astilbe grandis, known as “Ma sang gou bang”, are used as a Miao traditional medicine with anti-inflammatory and analgesic properties. However, the active components and mechanism of action of this plant remain mostly uncharacterized.
Jin-Fang Luo, Lan Yue, Tian-Tai Wu, Chen-Liang Zhao, Jiang-Hai Ye, Kang He, Juan Zou   +6 more
doaj   +1 more source

Novel biphasic role of lipoxinA4 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts [PDF]

, 2011
Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation.
Gao, F., Song, X. R., QingQuan Lian, Jin, Shengwei, Shengxing Zheng, Duyun Ye, He, Q., Fang Gao, Jin, S. W., Gao, Fang; id_orcid, Xiaorong Song, He, Qian, Qian Wang, Ye, Duyun, Wang, Q., Zheng, Shengxing, Ye, D. Y., Lian, Q. Q., Lian, QingQuan, Shengwei Jin, Song, Xiaorong, Qian He, Wang, Qian, Smith, F. Gao (Fang Gao), Zheng, S. X.   +24 more
core   +1 more source

Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats

Journal of Applied Oral Science, 2010
Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process.
Ricardo Nogueira Fracon, Juliana Mazzonetto Teófilo, Izabela Cristina Moris, Teresa Lamano   +3 more
doaj   +1 more source

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer [PDF]

, 2005
<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.
Mukherjee, R., Underwood, M.A., Edwards, J., Bartlett, J.M.S.   +3 more
core   +1 more source

COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake

Acta Neuropathologica Communications, 2019
Acetylsalicylic acid has been linked to a lower risk for different cancer types, presumably through its inhibitory effect on cyclooxygenase 2.
Felix Behling, Vanessa Ries, Marco Skardelly, Irina Gepfner-Tuma, Martin Schuhmann, Florian-Heinrich Ebner, Ghazaleh Tabatabai, Antje Bornemann, Jens Schittenhelm, Marcos Tatagiba   +9 more
doaj   +1 more source

Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E-2 production [PDF]

, 2004
Levels of prostaglandin E-2 (PGE(2)), a potent inhibitor of fibroblast function, are decreased in the lungs of patients with pulmonary fibrosis, which has been shown to be because of limited expression of cyclooxygenase-2 (COX-2).
McAnulty, R J, Martyn L. Foster, Laurent, G J, Rebecca J. Hodges, R. Gisli Jenkins, Geoffrey J. Bellingan, Jenkins, R G, Bellingan, GJ, Hart, S L, Laurent, GJ, Jenkins, RG, Bottoms, SE, Copeman, DM, Bottoms, S E, Geoffrey J. Laurent, Nanthakumar, C B, Foster, ML, Wheeler-Jones, C P D, Stephen L. Hart, Hodges, RJ, Wheeler-Jones, CPD, Robin J. McAnulty, Bellingan, G J, McAnulty, RJ, Nanthakumar, CB, Inst Child Hlth, Foster, M L, Stephen E. Bottoms, Copeman, D M, Caroline P.D. Wheeler-Jones, Carmel B. Nanthakumar, Hart, SL, Merck Sharp & Dohme, Hodges, R J, UCL, Danielle M. Copeman   +35 more
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Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling

Frontiers in Oncology, 2020
Pyruvate kinase M2 (PKM2) is a key enzyme of glycolysis, which is highly expressed in many tumor cells, and has emerged as an important player in tumor progression and metastasis.
Wenjing Guo, Wenjing Guo, Zhishuai Zhang, Guihuan Li, Xiaoju Lai, Ruonan Gu, Ruonan Gu, Wanfu Xu, Hua Chen, Zhe Xing, Liping Chen, Jiabi Qian, Shiyuan Xu, Fangyin Zeng, Fan Deng   +14 more
doaj   +1 more source

Cyclooxygenase-2 expression in cervical cancer [PDF]

Vojnosanitetski Pregled, 2014
Background/Aim. Cyclooxygenase (COX) or prostaglandin H2 synthase is the first enzyme that catalyzes the first two steps in the biosynthesis of prostaglandins from arachidonic acid.
Mandić Aljoša, Ušaj-Knežević Slavica, Ivković-Kapicl Tatjana, Ninčić Dejan, Malenković Goran   +4 more
doaj   +1 more source

Selective COX-2 inhibitors and risk of myocardial infarction [PDF]

, 2005
Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Sohn, Hae-Young, Klauss, V., Schiele, T. M., Krotz, F.   +3 more
core   +1 more source