Results 21 to 30 of about 128,590 (304)

Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats

Journal of Applied Oral Science, 2010
Prostaglandins control osteoblastic and osteoclastic function under physiological or pathological conditions and are important modulators of the bone healing process.
Ricardo Nogueira Fracon, Juliana Mazzonetto Teófilo, Izabela Cristina Moris, Teresa Lamano   +3 more
doaj   +1 more source

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer [PDF]

, 2005
<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.
Mukherjee, R., Underwood, M.A., Edwards, J., Bartlett, J.M.S.   +3 more
core   +1 more source

COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake

Acta Neuropathologica Communications, 2019
Acetylsalicylic acid has been linked to a lower risk for different cancer types, presumably through its inhibitory effect on cyclooxygenase 2.
Felix Behling, Vanessa Ries, Marco Skardelly, Irina Gepfner-Tuma, Martin Schuhmann, Florian-Heinrich Ebner, Ghazaleh Tabatabai, Antje Bornemann, Jens Schittenhelm, Marcos Tatagiba   +9 more
doaj   +1 more source

Cyclooxygenase-2 [PDF]

OncoImmunology, 2013
Cyclooxygenase-2 and its product PGE2 play essential roles in inducing and maintaining the suppressive functions of MDSCs in cancer. Blockade of the COX-2/PGE2 pathway abolishes the induction of MDSCs in response to tumor-derived factors and thus may provide new opportunities for targeting MDSCs in cancer patients.
Yumeng Mao, Isabel Poschke, Rolf Kiessling   +2 more
openaire   +2 more sources

Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E-2 production [PDF]

, 2004
Levels of prostaglandin E-2 (PGE(2)), a potent inhibitor of fibroblast function, are decreased in the lungs of patients with pulmonary fibrosis, which has been shown to be because of limited expression of cyclooxygenase-2 (COX-2).
McAnulty, R J, Martyn L. Foster, Laurent, G J, Rebecca J. Hodges, R. Gisli Jenkins, Geoffrey J. Bellingan, Jenkins, R G, Bellingan, GJ, Hart, S L, Laurent, GJ, Jenkins, RG, Bottoms, SE, Copeman, DM, Bottoms, S E, Geoffrey J. Laurent, Nanthakumar, C B, Foster, ML, Wheeler-Jones, C P D, Stephen L. Hart, Hodges, RJ, Wheeler-Jones, CPD, Robin J. McAnulty, Bellingan, G J, McAnulty, RJ, Nanthakumar, CB, Inst Child Hlth, Foster, M L, Stephen E. Bottoms, Copeman, D M, Caroline P.D. Wheeler-Jones, Carmel B. Nanthakumar, Hart, SL, Merck Sharp & Dohme, Hodges, R J, UCL, Danielle M. Copeman   +35 more
core   +1 more source

Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling

Frontiers in Oncology, 2020
Pyruvate kinase M2 (PKM2) is a key enzyme of glycolysis, which is highly expressed in many tumor cells, and has emerged as an important player in tumor progression and metastasis.
Wenjing Guo, Wenjing Guo, Zhishuai Zhang, Guihuan Li, Xiaoju Lai, Ruonan Gu, Ruonan Gu, Wanfu Xu, Hua Chen, Zhe Xing, Liping Chen, Jiabi Qian, Shiyuan Xu, Fangyin Zeng, Fan Deng   +14 more
doaj   +1 more source

Cyclooxygenase-2 in the Kidney [PDF]

Journal of the American Society of Nephrology, 2000
Prostaglandins are produced constitutively by many tissues in the body, including brain, gut, and kidney, and their synthesis increases at sites of inflammation. Cyclooxygenase (COX), the enzyme responsible for the initial rate-limiting metabolism of arachidonic acid to prostaglandin G2 ...
openaire   +2 more sources

Cyclooxygenase-2 expression in cervical cancer [PDF]

Vojnosanitetski Pregled, 2014
Background/Aim. Cyclooxygenase (COX) or prostaglandin H2 synthase is the first enzyme that catalyzes the first two steps in the biosynthesis of prostaglandins from arachidonic acid.
Mandić Aljoša, Ušaj-Knežević Slavica, Ivković-Kapicl Tatjana, Ninčić Dejan, Malenković Goran   +4 more
doaj   +1 more source

Selective COX-2 inhibitors and risk of myocardial infarction [PDF]

, 2005
Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Sohn, Hae-Young, Klauss, V., Schiele, T. M., Krotz, F.   +3 more
core   +1 more source

Evaluation of cyclooxygenase 2- gene expression in benign and malignant ascites [PDF]

Reviews in Clinical Medicine, 2020
Introduction: This study aimed to evaluate the mRNA expression of cyclooxygenase-2 (Cox-2) in ascites caused by various diseases. Moreover, it was attempted to investigate its usefulness in the differential diagnosis between malignant and benign ascites.
Raheleh Jabini, Arezoo Mirbolouk, mohamadreza farzanehfar   +2 more
doaj   +3 more sources