Results 41 to 50 of about 128,590 (304)

Kopplung der Cyclooxygenase 2 an sekundäre Enzyme [PDF]

, 2010
Die NSAR gehören zu den weltweit am häufigsten eingenommenen Schmerzmedikamenten. Sie hemmen die Cylooxygenase 1 und 2, Enzyme, die für die Produktion von Schmerzmediatoren (Prostaglandine) verantwortlich sind.
Kömhoff, Martin, Pilgramm, Elizabeth
core   +3 more sources

Antiinflamatórios não-hormonais: inibidores da ciclooxigenase 2 Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors

Jornal de Pediatria, 2006
OBJETIVO: Analisar os antiinflamatórios não-hormonais (AINH) inibidores seletivos da Cox 2 quanto ao mecanismo de ação, principais indicações, posologia e efeitos adversos mais comuns.
Maria Odete Esteves Hilário, Maria Teresa Terreri, Cláudio Arnaldo Len   +2 more
doaj   +1 more source

The Role of COX-2 and PGE2 in the Regulation of Immunomodulation and Other Functions of Mesenchymal Stromal Cells

Biomedicines, 2023
The ability of MSCs to modulate the inflammatory environment is well recognized, but understanding the molecular mechanisms responsible for these properties is still far from complete.
Agnieszka Kulesza, Leszek Paczek, Anna Burdzinska   +2 more
doaj   +1 more source

The Molecular Perspective: Cyclooxygenase-2 [PDF]

The Oncologist, 2000
Imagine preventing cancer before it even starts. Of course, cancer prevention starts at home. We can stay away from smoke, solvents, and sunlight, avoiding unnecessary risks to our cells. We can also eat healthy foods like fruits and vegetables that are filled with protective antioxidants and cleansing fiber.
openaire   +3 more sources

Early increased density of cyclooxygenase-2 (COX-2) immunoreactive neurons in Down syndrome [PDF]

, 2017
Neuroinflammation is one of the hallmarks of Alzheimer’s disease. One of the enzymes involved in neuroinflammation, even in early stages of the disease, is COX-2, an inducible cyclooxygenase responsible for the generation of eicosanoids and for the ...
José Miguel Blasco-Ibáńez, Carlos Crespo, Juan Nácher, Maria Mulet, Emilio Varea   +4 more
core   +1 more source

Cyclooxygenase‐2 in oligodendroglial neoplasms [PDF]

Cancer, 2003
AbstractBACKGROUNDAlthough increased expression of cyclooxygenase‐2 (COX‐2) has been described in association with a variety of neoplasms, including tumors of astrocytic derivation, limited data are available on COX‐2 expression in oligodendrogliomas.METHODSThe current study retrospectively reviewed 53 oligodendrogliomas and 7 oligodendroglioma ...
Elias A, Castilla, Richard A, Prayson, Andrew A, Kanner, Lisa A, Rybicki, Raymond R, Tubbs, Michael A, Vogelbaum, Gene H, Barnett   +6 more
openaire   +2 more sources

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs [PDF]

, 2014
Background—Cardiovascular side effects associated with cyclooxygenase-2 inhibitor drugs dominate clinical concern. Cyclooxygenase-2 is expressed in the renal medulla where inhibition causes fluid retention and increased blood pressure.
Warner, Timothy D., Mackenzie, L, Wang, Zhen, Armstrong, PCJ, Mitchell, JA, Kirkby, NS, Al’Yamani, Malak, Knowles, R, Al'Yamani, Malak, Armstrong, Paul C. J., Nuesing, RM, Knowles, Rebecca, Tomlinson, James A.P., Mitchell, Jane A., Mackenzie, Louise; id_orcid, Ahmetaj-Shala, Blerina, Wang, Z, Mackenzie, Louise, Al'Yamani, M, Ahmetaj-Shala, B, Mazi, S, Leiper, J, Nusing, Rolf M., Tomlinson, JAP, Tomlinson, James A. P., Mazi, Sarah, Mazi, Sara, Kirkby, Nicholas S., Armstrong, Paul C.J., Tucker, Arthur T., Warner, TD, Leiper, James, Tucker, AT   +32 more
core   +1 more source

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]

, 2006
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi Shankar, Candelario-Jalil, Eduardo, Munoz, Eduardo, Eduardo Muñoz, Michael Hüll, Lieb, Klaus, Klaus Lieb, Akundi, Ravi S., Ravi S. Akundi, Fiebich, Bernd L., Kurt Appel, Bhatia, Harsharan S., Eduardo Candelario-Jalil, Harsharan S. Bhatia, Hull, Michael, Bernd L. Fiebich, Appel, Kurt   +16 more
core   +1 more source