In situ click chemistry generation of cyclooxygenase-2 inhibitors [PDF]
Nature Communications, 2017 Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory ...
Atul Bhardwaj +3 more
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Effects of Cyclooxygenase Inhibitors on Apoptotic Neuroretinal Cells [PDF]
Biomarker Insights, 2008 Glaucoma is characterized by a loss of retinal ganglion cells (RGC) which is associated with a decrease of visual function. Neuroprotective agents as a new therapeutic strategy could prevent the remaining neurons from apoptotic cell death.
Anja-Kristina Brust +4 more
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Dual Effects of Cyclooxygenase Inhibitors in Combination With CD19.CAR-T Cell Immunotherapy [PDF]
Frontiers in Immunology, 2021 Chimeric antigen receptor T (CAR-T) cells targeting CD19 came into clinical practice for the treatment of B cell lymphoma in 2018. However, patients being treated for B cell lymphoma often suffer from comorbidities such as chronic pain, cardiovascular ...
Mingya Yang +24 more
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Stimulatory Action of Cyclooxygenase Inhibitors on Hematopoiesis: A Review [PDF]
Molecules, 2012 The presented review summarizes experimental data obtained with a mouse model when investigating the relationship between inhibition of prostaglandin production and hematopoiesis.
Lenka Weiterová +4 more
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Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance [PDF]
ChemMedChem, 2015 Wilma Neumann, Matthias Scholz
exaly +2 more sources
Cyclooxygenase-2 Inhibitors [PDF]
Anesthesia & Analgesia, 2003 Background and Summary— Selective cyclooxygenase (COX)-2 inhibitors are increasingly being used in place of “conventional” nonsteroidal anti-inflammatory drugs (NSAIDs). This is because they are just as effective as NSAIDs in relieving arthritic pain and yet less gastrotoxic.
Graeme J, Hankey, John W, Eikelboom
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Docking studies of some pyrazole containing compounds in the cyclooxygenase-2 active site [PDF]
Arhiv za farmaciju, 2023 Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and diclofenac, inhibit both cyclooxygenase-1 and cyclooxigenase-2 enzymes, selective inhibitors target cyclooxygenase-2, which is overexpressed in inflammation, but ...
Savić Jelena +3 more
doaj
Macrostachyols A-D, oligostilbenes from Gnetum macrostachyum inhibited in vitro human platelet aggregation [PDF]
Journal of HerbMed Pharmacology, 2021 Introduction: Gnetum macrostachyum is a known Thai medicinal plant as a source of bioactive oligostilbenes, which possess platelet inhibitory activities.
Serm Surapinit, Nuttakorn Baisaeng
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The overexpression of COX 2 in Wilms’ tumor [PDF]
Reviews in Clinical Medicine, 2014 Cyclooxygenase 2 has become an important pharmacological target in anticancer therapy due to the over expression of COX 2 in pathological conditions. Wilms’ tumor is a common kidney cancer in children which has shown an increase in COX 2 enzyme level ...
Sara Hashemi
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Cyclooxygenase (COX) Inhibitors and the Intestine [PDF]
Journal of Veterinary Internal Medicine, 2007 Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) have long been used for the treatment of pain and inflammation because of their inhibitory effects on cyclooxygenase (COX). For almost as long as NSAIDs have been in use, multiple adverse effects have been noted.
Dianne, Little +2 more
openaire +2 more sources