Results 1 to 10 of about 112,794 (342)

In Silico screening of nonsteroidal anti-inflammatory drugs and their combined action on Prostaglandin H Synthase-1 [PDF]

, 2010
The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective ...
Demin, Oleg, Goltsov, Alexey, Goltsov, Gregory, Goryanin, Igor, Humphery-Smith, Ian, Lebedeva, Galina   +5 more
core   +5 more sources

Systematic study of constitutive cyclo-oxygenase-2 expression: role of NFκB and NFAT transcriptional pathways [PDF]

, 2015
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs).
Ahmetaj-Shala, B, Berglund, LM, Chan, MV, Garcia-Vaz, E, Gomez, MF, Herschman, HR, Jiao, J, Kirkby, NS, Mitchell, JA, Verdu, EF, Wallace, JL, Zaiss, AK   +11 more
core   +1 more source

Evaluation of machine-learning methods for ligand-based virtual screening [PDF]

, 2007
Machine-learning methods can be used for virtual screening by analysing the structural characteristics of molecules of known (in)activity, and we here discuss the use of kernel discrimination and naive Bayesian classifier (NBC) methods for this purpose ...
A Bender, A Bender, A Bender, A Ormerod, A Ormerod, AE Klon, AM Capelli, AR Leach, B Chen, Beining Chen, C Williams, D Hand, D Rogers, D Wilton, DA Cosgrove, David J. Wood, DB Kitchen, DE Clark, DJ Hand, DJ Wilton, DM Hawkins, E Parzen, FL Stahura, G Harper, G Redl, G Schneider, George Papadatos, H Eckert, H Kubinyi, HM Berman, J Aitchison, J Bajorath, J Delaney, J Hert, J Hert, J Hert, JC Saeh, L Hodes, L Hodes, L Hodes, M Congreve, M Glick, M Glick, M Wagener, M Whittle, N Christianini, N Nikolova, Nikolaus Stiefl, P Constans, P Domingos, P Willett, P Willett, P Willett, P Willett, P Willett, Paulette Greenidge, Peter Willett, Q Zhang, R P Sheridan, RD Brown, RD Brown, RD Cramer, RE Carhart, RO Duda, Robert F. Harrison, S Anzali, TJ McNeany, TM Mitchell, Xiao Qing Lewell, XY Xia, YC Martin, YC Martin   +71 more
core   +2 more sources

Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats.

PLoS ONE, 2019
Nonsteroidal anti-inflammatory drugs and acetaminophen are cyclooxygenase inhibitors commonly used as symptomatic medicines for myofascial pain syndrome.
Tetsuhiro Shimodaira, Shigeo Mikoshiba, Toru Taguchi   +2 more
doaj   +1 more source

Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]

, 2004
Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo, Fiebich, Bernd L., García-Cabrera, Michel, González-Falcón, Armando, León, Olga S.   +4 more
core   +1 more source

Effect of multiple-dose regimens of cyclooxygenase inhibitors and their combinations with mexidol on behavior in mature rats

Фармакокинетика и Фармакодинамика, 2023
Effects of multiple-dose regimens (oral, daily, once a day for 15 days) of cyclooxygenase (COX) inhibitors etoricoxib (1 and 10 mg/kg), diclofenac sodium (1 and 5 mg/kg) and their combinations with 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexidol 25
E. A. Ivanova, A. G. Vasilchuk, A. I. Matyushkin, T. A. Voronina   +3 more
doaj   +1 more source

Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice [PDF]

, 2020
Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on ...
Claro Cala, Carmen María, Herrera González, María Dolores, Miñano Sánchez, Francisco Javier, Pérez Montero , Marta, Quintela, José Carlos, Rodríguez Rodríguez , Rosalía, Álvarez de Sotomayor Paz, María   +6 more
core   +1 more source

Cyclooxygenase-2 inhibitors: promise or peril?

Mediators of Inflammation, 2002
The discovery of two isoforms of the cyclooxygenase enzyme, COX-1 and COX-2, and the development of COX-2-specific inhibitors as anti-inflammatories and analgesics have offered great promise that the therapeutic benefits of NSAIDs could be optimized ...
Laurel J. Mengle-Gaw, Benjamin D. Schwartz   +1 more
doaj   +1 more source

Transactivation of EGFR by LPS induces COX-2 expression in enterocytes [PDF]

, 2012
Necrotizing enterocolitis (NEC) is the leading cause of gastrointestinal morbidity and mortality in preterm infants. NEC is characterized by an exaggerated inflammatory response to bacterial flora leading to bowel necrosis.
A Grishin, AA Fanaroff, AA Maynard, Anatoly Grishin, AO Fagbemi, AV Grishin, B Dvorak, B Lugo, BB Warner, BJ Stoll, BK Reuter, CE Shin, CL Leaphart, Claus Schneider, CP Sodhi, D Hsu, D. Brent Polk, DH Chung, Henri Ford, JA Clark, Jeffrey Upperman, JL Koff, Jörn-Hendrik Weitkamp, M Fukata, M Fukata, M Petrosyan, MD Halpern, Michael J. Rosen, Michael Kallen, Nathalie Signoret, Noemi Tejera, O Morteau, P Chailler, PJ Miettinen, Poojitha Matta, PW Lin, RR Nair, S Cetin, SC Fitzgibbons, SC Gribar, SC Gribar, SO Guthrie, Steven J. McElroy, Stuart Hobbs, T Jilling, T Yamaoka   +45 more
core   +3 more sources

The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation

Mediators of Inflammation, 1998
Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo, L. J. Damore, J. E. Mazuski, G. S. Smith, N. Panesar, D. L. Kaminski   +5 more
doaj   +1 more source