Results 31 to 40 of about 693,798 (288)

Antiproliferative Benzoindazolequinones as Potential Cyclooxygenase-2 Inhibitors

Molecules, 2019
Quinones and nitrogen heterocyclic moieties have been recognized as important pharmacophores in the development of antitumor agents. This study aimed to establish whether there was any correlation between the in silico predicted parameters and the in ...
Aurora Molinari, Alfonso Oliva, Marlene Arismendi-Macuer, Leda Guzmán, Waldo Acevedo, Daniel Aguayo, Raúl Vinet, Arturo San Feliciano   +7 more
doaj   +1 more source

In vitro and In Silico Studies on Curcumin and Its Analogues as Dual Inhibitors for cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2)

Journal of Mathematical and Fundamental Sciences, 2013
Curcumin has been widely reported as an anti-inflammatory agent isolated from the plant Curcuma longa L. (turmeric). This anti-inflammatory activity was associated with the ability of this compound to inhibit the activity of both cyclooxygenase-1 (COX-1)
Nunung Yuniarti, Perdana Adhi Nugroho, Aditya Asyhar, Sardjiman Sardjiman, Zullies Ikawati, Enade Perdana Istyastono   +5 more
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Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders

Frontiers in Psychiatry, 2019
Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder, are associated with significant illness burden.
Rickinder Sethi, Nieves Gómez-Coronado, Adam J. Walker, Oliver D’Arcy Robertson, Oliver D’Arcy Robertson, Bruno Agustini, Michael Berk, Michael Berk, Michael Berk, Michael Berk, Michael Berk, Seetal Dodd, Seetal Dodd, Seetal Dodd, Seetal Dodd   +14 more
doaj   +1 more source

New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases

Molecular Medicine, 2021
Age-related cardiovascular disease is the leading cause of death in elderly populations. Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib, are selective cyclooxygenase-2 (COX-2) inhibitors used to treat ...
Wujun Chen, Yingjie Zhong, Nuan Feng, Zhu Guo, Shuai Wang, Dongming Xing   +5 more
doaj   +1 more source

Synthesis and Biological Evaluation of Gentiopicroside Derivatives as Novel Cyclooxygenase-2 Inhibitors with Anti-Inflammatory Activity

Drug Design, Development and Therapy, 2023
Guojin Ren,1,* Qili Zhang,1,2,* Pengfei Xia,1– 4 Jie Wang,1 Pengxia Fang,1 Xiaojie Jin,1 Xuejing Peng,1– 4 Yanli Xu,1,5 Jian Zhang,1– 4 Lei Zhao1– 5 1Gansu University of Chinese Medicine, Lanzhou, 730000, People’s Republic of China; 2Northwest ...
Ren G, Zhang Q, Xia P, Wang J, Fang P, Jin X, Peng X, Xu Y, Zhang J, Zhao L   +9 more
doaj  

Effect of multiple-dose regimens of cyclooxygenase inhibitors and their combinations with mexidol on behavior in mature rats

Фармакокинетика и Фармакодинамика, 2023
Effects of multiple-dose regimens (oral, daily, once a day for 15 days) of cyclooxygenase (COX) inhibitors etoricoxib (1 and 10 mg/kg), diclofenac sodium (1 and 5 mg/kg) and their combinations with 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexidol 25
E. A. Ivanova, A. G. Vasilchuk, A. I. Matyushkin, T. A. Voronina   +3 more
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Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds

Journal of Inflammation Research, 2022
Mohamed A Abdelgawad,1 Mohammad M Al-Sanea,1 Arafa Musa,2 Mohammed Elmowafy,3 Ashraf K El-Damasy,4 Amany A Azouz,5 Mohammed M Ghoneim,6 Rania R Bakr7 1Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Al Jouf, 72341 ...
Abdelgawad MA, Al-Sanea MM, Musa A, Elmowafy M, El-Damasy AK, Azouz AA, Ghoneim MM, Bakr RR   +7 more
doaj  

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer [PDF]

, 2005
<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.
Mukherjee, R., Underwood, M.A., Edwards, J., Bartlett, J.M.S.   +3 more
core   +1 more source

Spherical harmonics coefficients for ligand-based virtual screening of cyclooxygenase inhibitors. [PDF]

PLoS ONE, 2011
Molecular descriptors are essential for many applications in computational chemistry, such as ligand-based similarity searching. Spherical harmonics have previously been suggested as comprehensive descriptors of molecular structure and properties.
Quan Wang, Kerstin Birod, Carlo Angioni, Sabine Grösch, Tim Geppert, Petra Schneider, Matthias Rupp, Gisbert Schneider   +7 more
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Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase

Molecules, 2015
Melanogenesis plays an important role in the protection of skin against UV through production of melanin pigments, but abnormal accumulation of this pigment causes unaesthetic hyperpigmentation. Much effort is being made to develop effective depigmenting
Binh Cao Quan Nguyen, Shinkichi Tawata
doaj   +1 more source