Results 51 to 60 of about 63,877 (297)
Cyclooxygenase-2 inhibitors: what went wrong? [PDF]
, 2006 Purpose of review: This review describes the biology underpinning the development of selective cyclooxygenase-2 inhibitors, documenting the clinical experience from the pivotal gastrointestinal safety trials to their eventual withdrawal or labelling with
Cleland, L., James, M.
core +1 more source
Frontiers in Neurology, 2018 BackgroundDespite seemingly functional coagulation, hemorrhagic lesion progression is a common and devastating condition following traumatic brain injury (TBI), stressing the need for new diagnostic techniques.
Caroline Lindblad +7 more
doaj +1 more source
Molecules, 2021 Pterocephalus hookeri, as a kind of popular traditional Tibetan medicine, is reputed to treat inflammatory related diseases. In the present work, a cyclooxygenase-2 functionalized affinity solid-phase extraction HPLC system was developed and combined ...
Yunhe Zhu +8 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Study of molecular simulation Cyclooxygenase-1 and Cyclooxygenase-2 Inhibitors [PDF]
, 2009 [[abstract]]In this study, molecular simulations are used to search COX-1 and COX-2 inhibitors. The cyclooxygenase in the mammal mainly has two different isoforms that are COX-1 and COX-2.
Pin-chen Liu
core
Pharmacology of cyclooxygenase-2 inhibitors and preemptive analgesia in acute pain management [PDF]
, 2008 NSAIDs have served as analgesic, antiinflammatory, and antipyretic medicines for over a century. A novel class of NSAIDs, cyclooxygenase-2 inhibitors, was introduced in 1999.
Baluch, Amir +5 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Clinical use of cyclooxygenase inhibitors impairs vitamin B-6 metabolism [PDF]
, 2014 Background: A low circulating vitamin B-6 concentration, which is an independent risk factor for cardiovascular disease, is commonly seen in human inflammation.Objective: We investigated whether cyclooxygenase inhibitors alter vitamin B-6 metabolism ...
Lan JL +7 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years
Acta Pharmaceutica Sinica B, 2022 Cyclooxygenases play a vital role in inflammation and are responsible for the production of prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and the inducible cyclooxygenase-2, for which the target inhibitors are the ...
Zhiran Ju +5 more
doaj +1 more source