Results 61 to 70 of about 693,798 (288)

The role of cyclooxygenase inhibitors in lipopolysaccharide-induced hypophagia in chicken

Czech Journal of Animal Science, 2015
Previous studies showed that cyclooxygenase 1 (COX) enzyme has an important role in lipopolysaccharide (LPS)-induced hypophagia in mammals but the effect of COX on LPS-induced hypophagia has not been studied in avian species.
M. Zendehdel, A. Baghbanzadeh, B. Yeganeh, S. Hassanpour   +3 more
doaj   +1 more source

Nonsteroidal anti-inflammatory drugs as potential ecto-nucleotide phosphodiesterase inhibitors

Brazilian Journal of Pharmaceutical Sciences, 2020
Phosphodiesterases (PDE) are group of enzymes which catalyze the hydrolysis of cAMP and cGMP. Since these cyclic phosphate moieties worked as intracellular second messengers in numerous physiological processes, their inhibition can affect normal ...
Shumaila Tasneem, Muhammad Saleem, Sheikh Arshad Saeed   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Effect of paracetamol and celecoxib on the state of hemocoagulation in the most acute period of heat injury in rats

Medičnì Perspektivi
 Acute heat injury (AHI) occurs due to exposure to high environmental temperatures and is considered a dangerous condition that requires effective prevention and treatment.
P.O. Chuykova, S.Yu. Shtrygol’, I.O. Lebedynets, D.V. Lytkin   +3 more
doaj   +1 more source

Congenital ventricular septal defects and prenatal exposure to cyclooxygenase inhibitors

Brazilian Journal of Medical and Biological Research, 2006
Ventricular septal defects (VSDs) are common congenital abnormalities which have been reported to be associated with maternal fever and various environmental factors.
F. Burdan, J. Szumilo, J. Dudka, A. Korobowicz, R. Klepacz   +4 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells [PDF]

, 2011
Cyclic AMP (cAMP) is the archetypal smooth muscle relaxant, mediating the effects of many hormones and drugs. However, recently PGI2, acting via cAMP/PKA, was found to increase contraction-associated protein expression in myometrial cells and to promote ...
Mandeep Kandola, Mark R. Johnson, Kandola, Mandeep, Zhiqing Liang, Johnson, Mark R., Chen, Li, Lei, Kaiyu, Sooranna, Suren R, Phillip R. Bennett, Dimitri Grammatopoulos, Grammatopoulos, Dimitris, Bennett, Phillip, Johnson, Mark R, Suren R. Sooranna, Chen, Li I., Li Chen, Kaiyu Lei, Sooranna, Suren R., Grammatopoulos, Dimitri, Liang, Zhiqing, Bennett, Phillip R   +20 more
core   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

NSAIDs and Cell Proliferation in Colorectal Cancer

Pharmaceuticals, 2010
Colon cancer is common worldwide and accounts for significant morbidity and mortality in patients. Fortunately, epidemiological studies have demonstrated that continuous therapy with NSAIDs offers real promise of chemoprevention and adjunct therapy for ...
Raj Ettarh, Anthony Cullen, Alvise Calamai   +2 more
doaj   +1 more source

Clinical experience with cyclooxygenase-2 inhibitors [PDF]

Rheumatology, 2002
Rheumatoid arthritis (RA) and osteoarthritis (OA) are chronic conditions requiring long-term therapy for pain relief. Currently prescribed non-steroidal anti-inflammatory drugs (NSAIDs) provide symptomatic efficacy, but are frequently associated with gastrointestinal (GI) toxicities such as dyspepsia and ulcerations.
openaire   +2 more sources