Results 81 to 90 of about 693,798 (288)
Deuterium-Enriched Water Increases the Cytotoxicity of Cyclooxygenase Inhibitors in Hep-G2 Hepatocellular Carcinoma Cells; Involvement of MAPK Pathway and Apoptosis [PDF]
Journal of Kerman University of Medical SciencesBackground: One of the most prevalent forms of liver cancer globally is the hepatocellular carcinoma (HCC). Increasing evidence from both clinical settings and experimental studies indicates that cyclooxygenase (COX) enzymes could play a role in the ...
Elham Sharif +2 more
doaj +1 more source
Study of molecular simulation Cyclooxygenase-1 and Cyclooxygenase-2 Inhibitors
, 2009 [[abstract]]In this study, molecular simulations are used to search COX-1 and COX-2 inhibitors. The cyclooxygenase in the mammal mainly has two different isoforms that are COX-1 and COX-2.
Pin-chen Liu
core
Arthritis Care &Research, EarlyView.Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer +4 more
wiley +1 more source
Medičnì PerspektiviAcute heat injury (AHI) is a serious condition caused by an excessive increase in body temperature, usually due to prolonged exposure to high environmental temperatures or intense physical activity in the heat.
P.O. Chuikova , S.Yu. Shtrygol’
doaj +1 more source
Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis
Arthritis Care &Research, EarlyView.Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang +21 more
wiley +1 more source
Search for New Compounds with Anti-Inflammatory Activity Among 1,2,4-Triazole Derivatives
MoleculesCompounds containing the 1,2,4-triazole moiety in their structure exhibit broad biological activities. Many of these compounds demonstrate anti-inflammatory activity in vitro through various mechanisms, such as inhibiting COX-1/COX-2 and LOX, modulating ...
Teresa Glomb +4 more
doaj +1 more source
Discovery of potential cyclooxygenase inhibitors using in silico docking studies
Bangladesh Journal of Pharmacology, 2012 This study deals with the evaluation of the cyclooxygenase inhibitory activity of flavonoids (tangeritin, morin, rhamnetin, theaflavin, pachypodol, eriodictyol, homoeriodictyol, aromadedrin, okanin) using in silico docking studies.
Arumugam Madeswaran +5 more
doaj +1 more source
Prostaglandin E Positively Modulates Endothelial Progenitor Cell Homeostasis: An Advanced Treatment Modality for Autologous Cell Therapy [PDF]
, 2009 Aims: The mobilization of endothelial progenitor cells (EPC) and their functioning in postnatal neovascularization are tightly regulated. To identify new modulators of EPC homeostasis, we screened biologically active prostaglandin E compounds for their ...
Hermann, Patrick C. +6 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato +27 more
wiley +1 more source
PathogensAcanthamoeba castellanii, an opportunistic free-living amoeba, causes severe infections including Acanthamoeba keratitis. This exploratory study evaluated whether three non-steroidal anti-inflammatory drugs (NSAIDs)—acetylsalicylic acid, ibuprofen, and ...
Verónica I. Hernández-Ramírez +11 more
doaj +1 more source