Results 21 to 30 of about 101,675 (258)

Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles

Journal of Lipid Research, 1973
A comparative study was made on the fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in various subcellular fractions of liver and testis from rats of different ages.
Sixta Ayala, Graciela Gaspar, Rodolfo R. Brenner, Raúl O. Peluffo, Wolf Kunau   +4 more
doaj   +1 more source

Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase

Journal of Lipid Research, 2000
The demonstration of in vivo arachidonic acid epoxidation and ω-hydroxylation established the cytochrome P450 epoxygenase and ω/ω–1 hydroxylase as formal metabolic pathways and as members of the arachidonate metabolic cascade. The characterization of the
Jorge H. Capdevila, John R. Falck, Raymond C. Harris   +2 more
doaj   +1 more source

Measurement of arachidonic acid in the plasma by gas-liquid chromatography-flame ionization using dihomo-gamma-linolenic acid as an internal standard.

Journal of Lipid Research, 1979
A gas-liquid chromatography-flame ionization method is described for measuring arachidonic acid in plasma using dihomo-gamma-linolenic acid as an internal standard.
J G Gerber, J S Barnes, A S Nies
doaj   +1 more source

Dietary arachidonic acid: a Janus face actor in brain and Alzheimer’s disease?

Oilseeds and fats, crops and lipids, 2018
Arachidonic acid is the second polyunsaturated fatty acid in brain and the first one belonging to the ω-6 series. Dietary intakes of arachidonic are between 50 and 300 mg/day in western diets but they might be underestimated. Triglycerides from fat would
Pinchaud Katleen, Maguin-Gaté Katy, Olivier Jean-Luc   +2 more
doaj   +1 more source

FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer

Nature Communications, 2023
Colonocyte metabolism shapes the microbiome. Metabolites are the main mediators of information exchange between intestine and microbial communities. Arachidonic acid (AA) is an essential polyunsaturated fatty acid and its role in colorectal cancer (CRC ...
Chunjie Xu, Lei Gu, Lipeng Hu, Chunhui Jiang, Qing Li, Longci Sun, Hong Zhou, Ye Liu, Hanbing Xue, Jun Li, Zhigang Zhang, Xueli Zhang, Qing Xu   +12 more
doaj   +1 more source

Effect of fatty acid modification on prostaglandin production by cultured 3T3 cells.

Journal of Lipid Research, 1982
We have investigated the extent to which modifications in the essential fatty acid content of mammalian cells can affect prostaglandin production.
G M Denning, P H Figard, A A Spector
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Adipose tissue arachidonic acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques

Lipids in Health and Disease, 2013
Background The content of arachidonic acid in adipose tissue is positively associated with the risk of myocardial infarction, whereas the content of eicosapentaenoic acid in adipose tissue has been reported to be negatively associated with the risk of ...
Nielsen Michael S, Grønholdt Marie-Louise M, Vyberg Mogens, Overvad Kim, Andreasen Annette, Due Karen-Margrete, Schmidt Erik B   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source