Results 1 to 10 of about 647,962 (308)

The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats

open access: yesFrontiers in Neuroscience, 2018
The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted.
Nermin Eissa   +5 more
doaj   +1 more source

P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology

open access: yesFrontiers in Pharmacology, 2017
Adenosine 5′-triphosphate is a well-known extracellular signaling molecule and neurotransmitter known to activate purinergic P2X receptors. Information has been elucidated about the structure and gating of P2X channels following the determination of the ...
Leanne Stokes   +5 more
doaj   +1 more source

Preclinical Assessment of a Cannabinoid CB2 Receptor Antagonist in a Murine Model of Cerebral Malaria

open access: yesJournal of Trial and Error
Malaria is a most important parasitic disease due to its highest impact worldwide. It results in around 200 million clinical cases and 0,5-1 million deaths per year, mainly due to cerebral malaria (CM), a life-threatening neurological syndrome that ...
Ana Borrego Escartín   +5 more
doaj   +1 more source

Microbes vs. Nematodes: Insights into Biocontrol through Antagonistic Organisms to Control Root-Knot Nematodes

open access: yesPlants, 2023
Root-knot nematodes (Meloidogyne spp.) are sedentary endoparasites that cause severe economic losses to agricultural crops globally. Due to the regulations of the European Union on the application of nematicides, it is crucial now to discover eco ...
Adil Ameen Bhat   +4 more
doaj   +1 more source

Métodos semiempíricos para la evaluación rápida de orbitales frontera en la clasificación de agonistas y antagonistas de la subunidad NR1 de los receptores iGluR-NMDA

open access: yesUniversitas Scientiarum, 2010
Los receptores iGluR-NMDAposeen gran interés farmacológico debido a que están implicadosen desordenes neurodegenerativos y neurosiquiátricos inclusoparticipan en procesos como plasticidad sináptica, esencial para la formación de la memoria.
Juvenal Yosa-Reyes   +3 more
doaj   +1 more source

Emergence of an Auxin Sensing Domain in Plant-Associated Bacteria

open access: yesmBio, 2023
Bacteria have evolved a sophisticated array of signal transduction systems that allow them to adapt their physiology and metabolism to changing environmental conditions. Typically, these systems recognize signals through dedicated ligand binding domains (
José A. Gavira   +9 more
doaj   +1 more source

THE ANTIFUNGAL ACTIVITY OF ENDOPHYTE FUNGUS FROM RUBBER LEAVES IN VITRO AND ITS ANTAGONIST MECHANISM OF COLLETOTRICHUM GLOEOSPORIOIDES

open access: yesRussian Journal of Agricultural and Socio-Economic Sciences, 2021
Rubber tree disease is the most important disturbing factor compared to other disorders. There have been found 25 types of diseases in rubber estate, and the most important one is Colletotrichum leaf spot caused by Colletotrichum gloesporioides. Recently,
Syamsafitri   +3 more
doaj   +1 more source

Endemic Jeffrey Pine Beetle Associates: Beetle/Mite Fungal Dissemination Strategies and Interactions That May Influence Beetle Population Levels

open access: yesMicroorganisms, 2021
Fungal and mite associates may drive changes in bark beetle populations, and mechanisms constraining beetle irruptions may be hidden in endemic populations.
Javier E. Mercado   +2 more
doaj   +1 more source

Design, synthesis and biological evaluation of novel biphenylsulfonamide derivatives as selective AT2 receptor antagonists

open access: yesFrontiers in Chemistry, 2022
A novel series of benzenesulfonamide derivatives that selectively act on the AT2 receptor have been designed and synthesized. The binding affinity and functional activity were evaluated by radio-ligand binding analysis and cell neurite outgrowth assay ...
Danhui Wang   +7 more
doaj   +1 more source

Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial [PDF]

open access: yesInternational Journal of Fertility and Sterility
Background: It is difficult to obtain healthy oocytes in poor ovarian responders with conventional treatment methods.Thus, the need to investigate new methods is essential.
Fatemeh Ghahghayi   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy