Results 1 to 10 of about 919,029 (311)

Intellectual Capital and Chaos of Innovation: Antagonist Coalition in Organizations

Istanbul Management Journal, 2023
As a critical resource of human capital, employees might be the leading supporters of innovation management considering the integrated intellectual capital.
Asiye Yüksel
doaj   +1 more source

Targeting TNFR2 in Cancer: All Roads Lead to Rome

Frontiers in Immunology, 2022
TNF receptor 2 (TNFR2) has become one of the best potential immune checkpoints that might be targeted, mainly because of its vital role in tumor microenvironments (TMEs).
Jingchao Bai, Jingchao Bai, Jingchao Bai, Bowen Ding, Bowen Ding, Bowen Ding, Hui Li, Hui Li, Hui Li   +8 more
doaj   +1 more source

GPR35 antagonist CID-2745687 attenuates anchorage-independent cell growth by inhibiting YAP/TAZ activity in colorectal cancer cells

Frontiers in Pharmacology, 2023
Background and purpose: GPR35, a member of the orphan G-protein-coupled receptor, was recently implicated in colorectal cancer (CRC). However, whether targeting GPR35 by antagonists can inhibit its pro-cancer role has yet to be answered.Experimental ...
Wuxiyar Otkur, Xiaolong Liu, Huan Chen, Siyi Li, Ting Ling, Hanchen Lin, Renyu Yang, Tian Xia, Huan Qi, Hai-Long Piao   +9 more
doaj   +1 more source

Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders

Frontiers in Pharmacology, 2021
Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established.
Kotaro Sakamoto, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Teruaki Masutani, Kenji Ishimoto, Kenji Ishimoto, Kenji Ishimoto, Nobumasa Hino, Shinsaku Nakagawa, Shinsaku Nakagawa, Shinsaku Nakagawa, Satoshi Asano, Yukio Ago, Yukio Ago, Yukio Ago, Yukio Ago   +16 more
doaj   +1 more source

Prolactin receptor signaling: A novel target for cancer treatment - Exploring anti-PRLR signaling strategies

Frontiers in Endocrinology, 2023
Prolactin (PRL) is a peptide hormone mainly secreted from the anterior pituitary gland. PRL is reported to play a role in pregnancy, mammary gland development, immune modulation, reproduction, and differentiation of islet cells. PRL binds to its receptor
David Standing, Prasad Dandawate, Shrikant Anant   +2 more
doaj   +1 more source

Adverse cardiovascular effect following gonadotropin-releasing hormone antagonist versus GnRH agonist for prostate cancer treatment: A systematic review and meta-analysis

Frontiers in Endocrinology, 2023
BackgroundAndrogen deprivation therapy is the mainstay of medical treatment for prostate cancer (Pca); however, it is associated with an increased risk of adverse cardiovascular (CV) events and death.
Li Gu, Xurui Li, Wentao Liu
doaj   +1 more source

First Molecular Characterization of sp. and sp. Isolated from Mangrove in Mexico and the Antagonist Effect of as an Effective Biocontrol Agent [PDF]

The Plant Pathology Journal, 2021
The aim of this study was to characterize potential fungal species affecting mangrove species in Mexico. The phytopathogens were identified based on morphological and molecular characteristics using internal transcribed spacer (ITS1/ITS4) primers then ...
Mayra I. Grano-Maldonado, Rosalio Ramos-Payan, Fernando Rivera-Chaparro, Maribel Aguilar-Medina, José Geovanni Romero-Quintana, Amparo Rodríguez-Santiago, Mario Nieves-Soto   +6 more
doaj   +1 more source

The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. [PDF]

, 2013
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases.
Czimmer, József, Hoffman, Diane C, Kehne, John, Luckey, Andrew, Maynard, George D, Million, Mulugeta, Taché, Yvette, Zhao, Jing-Fang   +7 more
core   +10 more sources

Modern aspects in anesthesia of small laboratory animals

Южно-Российский онкологический журнал, 2022
Experiments with small laboratory animals are required for better understanding of a disease flow, for studying the mechanisms of it’s development and for the development of new therapeutic strategies.
S. V. Gurova, M. V. Mindar, D. V. Khodakova   +2 more
doaj   +1 more source

Development of tolerance to chemokine receptor antagonists: current paradigms and the need for further investigation

Frontiers in Immunology, 2023
Chemokine G-protein coupled receptors are validated drug targets for many diseases, including cancer, neurological, and inflammatory disorders. Despite much time and effort spent on therapeutic development, very few chemokine receptor antagonists are ...
Patrick Grudzien, Henry Neufeld, Mbasogo Ebe Eyenga, Vadim Gaponenko   +3 more
doaj   +1 more source