Results 1 to 10 of about 1,927,651 (292)

Regulatory T cells in hypoxic environments [PDF]

Frontiers in Immunology
Oxygen availability is considered as an important determinant of immune regulation, yet its impact on regulatory T cells remains incompletely understood. In this review, we synthesize current evidence on how chronic and intermittent hypoxia influence the
Lourdes González-Rivera, Lourdes González-Rivera, Rodrigo Luna-Gutiérrez, Stephanie Cárdenas, Consuelo Merino-González, Alex Handy, Inés Pepper, Mercedes Natalia López   +7 more
doaj   +2 more sources

Regulatory T cells in axial spondyloarthritis [PDF]

Communications Biology
Type 3 immunity underlies both pain and inflammation in axial spondyloarthritis (axSpA), with IL-17A-producing cells such as T-helper 17 cells (TH17) being pathogenic mediators.
Addison Pacheco, Fataneh Tavasolian, Melissa Lim, Robert D. Inman   +3 more
doaj   +2 more sources

Higher frequency of circulating regulatory T cells is associated with poor outcomes in patients with colorectal cancer [PDF]

Discover Oncology
Background While immune dysregulation significantly influences colorectal cancer (CRC) progression, this study aimed to investigate the levels of circulating regulatory T cells (cTreg) and their subsets, follicular helper T cells (cTfh), and follicular ...
Yan Lu, Haoyang Guo, Taotao Guo, Longyi Zhang, Xinling Pan   +4 more
doaj   +2 more sources

MCSF drives regulatory DC development in stromal co-cultures supporting hematopoiesis [PDF]

BMC Immunology, 2018
Background Splenic stroma overlaid with hematopoietic progenitors supports in vitro hematopoiesis with production of dendritic-like cells. Co-cultures of murine lineage-depleted bone marrow over the 5G3 stromal line produce two populations of cells ...
Sawang Petvises, Pravin Periasamy, Helen C. O’Neill   +2 more
doaj   +4 more sources

The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities

Frontiers in Immunology, 2021
Regulatory T cells (Tregs) are an immunosuppressive subgroup of CD4+ T cells which are identified by the expression of forkhead box protein P3 (Foxp3). The modulation capacity of these immune cells holds an important role in both transplantation and the ...
Fatemeh Bayati, Fatemeh Bayati, Mahsa Mohammadi, Mahsa Mohammadi, Maryam Valadi, Saeid Jamshidi, Arron Munggela Foma, Ehsan Sharif-Paghaleh, Ehsan Sharif-Paghaleh   +8 more
doaj   +1 more source

Naïve-memory regulatory T cells ratio is a prognostic biomarker for patients with acute ischemic stroke

Frontiers in Aging Neuroscience, 2023
BackgroundRegulatory T cells (Treg) have been identified as a key modulator of neuroinflammation in stroke. However, little is known about the association of Treg subpopulations with clinical outcome in patients with acute ischemic stroke (AIS ...
Gang Deng, Yue Tang, Jun Xiao, Xin Chen, Yun-Hui Chu, Ke Shang, Luo-Qi Zhou, Chuan Qin, Feng Wang, Dai-Shi Tian   +9 more
doaj   +1 more source

Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells

Journal for ImmunoTherapy of Cancer, 2022
Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME).
Marco Donia, Mads Hald Andersen, Özcan Met, Lars Grøntved, Daniel Hargbøl Madsen, Inge Marie Svane, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum   +14 more
doaj   +1 more source

Highly sensitised individuals present a distinct Treg signature compared to unsensitised individuals on haemodialysis

Frontiers in Transplantation, 2023
IntroductionHighly sensitised (HS) patients represent up to 30% of patients on the kidney transplant waiting list. When they are transplanted, they have a high risk of acute/chronic rejection and long-term allograft loss.
C. Dudreuilh, C. Dudreuilh, S. Basu, S. Basu, O. Shaw, H. Burton, H. Burton, N. Mamode, N. Mamode, F. Harris, T. Tree, P. Nedyalko, M. Terranova-Barberio, G. Lombardi, C. Scottà, A. Dorling, A. Dorling   +16 more
doaj   +1 more source

B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions

Frontiers in Cell and Developmental Biology, 2022
B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions.
Diaoyi Tan, Diaoyi Tan, Wei Yin, Fei Guan, Wanjiang Zeng, Pamela Lee, Fabio Candotti, Louisa K James, Niels Olsen Saraiva Camara, S.M. Mansour Haeryfar, Yan Chen, Kamel Benlagha, Lewis Zhichang Shi, Jiahui Lei, Quan Gong, Quan Gong, Zheng Liu, Chaohong Liu   +17 more
doaj   +1 more source

Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]

, 2020
Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis, Bosenberg, Marcus, Bradley, Linda M, Brown, Kevin, Dolgalev, Igor, Feng, Yongmei, Hockemeyer, Kathryn, Li, Yan, Marine, Jean-Christophe, Otero, Dennis C, Poźniak, Joanna, Rambow, Florian, Ronai, Ze'ev A, Scortegagna, Marzia, Tinoco, Roberto, Zhang, Tongwu   +15 more
core   +2 more sources