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Regulatory T cells as immunotherapy [PDF]
Frontiers in Immunology, 2014 Regulatory T cells (Tregs) suppress exuberant immune system activation and promote immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the biomedical community has developed intense interest in using Tregs for immunotherapy.
Benjamin David Singer +2 more
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Regulatory T cells in paracoccidioidomycosis [PDF]
Virulence, 2019 This review addresses the role of regulatory T cells (Tregs), which are essential for maintaining peripheral tolerance and controlling pathogen immunity, in the host response against Paracoccidioides brasiliensis, a primary fungal pathogen.
Vera L. G. Calich +2 more
doaj +3 more sources
Regulatory T cells in hypoxic environments [PDF]
Frontiers in ImmunologyOxygen availability is considered as an important determinant of immune regulation, yet its impact on regulatory T cells remains incompletely understood. In this review, we synthesize current evidence on how chronic and intermittent hypoxia influence the
Lourdes González-Rivera +7 more
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Regulatory T cells in axial spondyloarthritis [PDF]
Communications BiologyType 3 immunity underlies both pain and inflammation in axial spondyloarthritis (axSpA), with IL-17A-producing cells such as T-helper 17 cells (TH17) being pathogenic mediators.
Addison Pacheco +3 more
doaj +2 more sources
Anti-regulatory T cells are natural regulatory effector T cells [PDF]
Cell Stress, 2019 Niels Ødum
doaj +5 more sources
The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) are an immunosuppressive subgroup of CD4+ T cells which are identified by the expression of forkhead box protein P3 (Foxp3). The modulation capacity of these immune cells holds an important role in both transplantation and the ...
Fatemeh Bayati +8 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2023 BackgroundRegulatory T cells (Treg) have been identified as a key modulator of neuroinflammation in stroke. However, little is known about the association of Treg subpopulations with clinical outcome in patients with acute ischemic stroke (AIS ...
Gang Deng +9 more
doaj +1 more source
Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Journal for ImmunoTherapy of Cancer, 2022 Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME).
Marco Donia +14 more
doaj +1 more source
Journal of Investigative Dermatology, 2006 Immunologic self-tolerance is critically dependent on the induction but also on the downregulation of immune responses. Though ignored and neglected for many years, suppressor T cells, now renamed regulatory T cells (Tregs), play an important role in the negative regulation of immune responses. Several subsets of Tregs have been described.
Beissert, Stefan +2 more
openaire +2 more sources