Results 1 to 10 of about 67,800 (143)

Elevated Proportions of Circulating CXCR5+ Follicular Helper T Cells Reflect the Presence of Airway Obstruction in Asthma [PDF]

Journal of Immunology Research
Rationale. The progressive decline in lung function observed in asthma is attributed to persistent type 2 airway inflammation and associated airway remodeling. While various immune cells are involved in localized type 2 airway inflammation, whether these
Tsukie Kin Tsukuda, Kimiko Tsuji, Akari Nishimori, Takehiko Ito, Yuka Kobayashi, Taro Suzuki, Akihito Yokoyama   +6 more
doaj   +2 more sources

Follicular regulatory T cells eliminate HIV-1-infected follicular helper T cells in an IL-2 concentration dependent manner [PDF]

Frontiers in Immunology, 2022
Follicular helper CD4+ T cells (TFH) are highly permissive to HIV and major foci of virus expression in both untreated and treated infection. Follicular regulatory CD4+ T cells (TFR) limit TFH numbers and function in vitro and in vivo.
Matthew T. Ollerton, Joy M. Folkvord, Andriana La Mantia, David A. Parry, Amie L. Meditz, Martin D. McCarter, Richard T. D’Aquila, Elizabeth Connick   +7 more
doaj   +2 more sources

Human follicular helper T lymphocytes critical players in antibody responses

Einstein (São Paulo), 2021
Follicular helper T lymphocytes are a subpopulation of CD4+ T lymphocytes initially identified in germinal centers of follicles found in secondary lymphoid organs. The primary function of follicular helper T lymphocytes is to help B lymphocytes’ antibody
Giovana Toledo Alonso, Denilson Stork Fomin, Luiz Vicente Rizzo   +2 more
doaj   +2 more sources

T follicular helper cells and T follicular regulatory cells in autoimmune diseases

Frontiers in Immunology, 2023
T follicular helper (Tfh) cells are heterogeneous and mainly characterized by expressing surface markers CXCR5, ICOS, and PD-1; cytokine IL-21; and transcription factor Bcl6.
Jingjing Qi, Chang Liu, Ziran Bai, Xia Li, Genhong Yao   +4 more
doaj   +1 more source

Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cells

Frontiers in Immunology, 2023
T follicular helper cells comprise a specialized, heterogeneous subset of immune-competent T helper cells capable of influencing B cell responses in lymphoid tissues.
Julien Subburayalu, Julien Subburayalu, Julien Subburayalu   +2 more
doaj   +1 more source

Peripheral T-Cell Lymphomas of the T Follicular Helper Type: Clinical, Pathological, and Genetic Attributes

Hemato, 2022
Follicular helper T-cell (TFH) lymphomas comprise a unique group of T-cell lymphomas that represent neoplastic proliferations of follicular helper T-cells and share genetic, immunophenotypic, morphologic, and clinical features.
Karthik A. Ganapathi, Kristin H. Karner, Madhu P. Menon   +2 more
doaj   +1 more source

TFH cells in systemic sclerosis

Journal of Translational Medicine, 2021
Systemic sclerosis is an autoimmune disease characterized by excessive dermal fibrosis with progression to internal organs, vascular impairment and immune dysregulation evidenced by the infiltration of inflammatory cells in affected tissues and the ...
Pauline Beurier, Laure Ricard, Deborah Eshagh, Florent Malard, Lama Siblany, Olivier Fain, Mohamad Mohty, Béatrice Gaugler, Arsène Mekinian   +8 more
doaj   +1 more source

Editorial: Follicular Helper T Cells in Immunity and Autoimmunity [PDF]

Frontiers in Immunology, 2020
Maria Pia Cicalese, Maria Pia Cicalese, Shahram Salek-Ardakani, Georgia Fousteri   +3 more
doaj   +2 more sources

Plasticity within the αβ+CD4+ T-cell lineage: when, how and what for? [PDF]

Open Biology, 2013
Following thymic output, αβ+CD4+ T cells become activated in the periphery when they encounter peptide–major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages ...
Stephanie M. Coomes, Victoria S. Pelly, Mark S. Wilson   +2 more
doaj   +1 more source

PU.1 expression in T follicular helper cells limits CD40L-dependent germinal center B cell development. [PDF]

, 2015
PU.1 is an ETS family transcription factor important for the development of multiple hematopoietic cell lineages. Previous work demonstrated a critical role for PU.1 in promoting Th9 development, and in limiting Th2 cytokine production. Whether PU.1 has
Awe, Olufolakemi, Chang, Hua-Chen, Dent, Alexander L., Hufford, Matthew M., Jabeen, Rukhsana, Kaplan, Mark H., Pham, Duy, Wu, Hao   +7 more
core   +1 more source