Results 41 to 50 of about 13,929,929 (284)
Regulatory T cell-mediated control of chronic inflammation
Frontiers in Immunology, 2012 Autoimmune inflammation including autoantibody-mediated inflammation is responsible for the lethal organ damage that occurs during autoimmune diseases.
Keishi eFujio +3 more
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Follicular helper T-cell–related lymphomas [PDF]
Blood, 2015 In this issue of Blood, Wang et al describe the occurrence and pathogenetic relevance of IDH2R172 mutations in angioimmunoblastic T-cell lymphoma (AITL).
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CD4 T follicular helper cells in HIV
, 2022 HIV infects millions of individuals worldwide, and new things still emerge. Once infected, the virus cannot be cleared by the system and causes non-heritable immunological disorder syndrome. Combination antiretroviral therapeutic program effectively suppresses microorganism replication and halts malady progression.
Cebo,Daniel +2 more
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PLoS ONE, 2017 IntroductionHIV causes defects in memory B cells in children, but the mechanisms of those defects have not been fully elucidated. One possible mechanism is the lack of T-cell help to B cells during immune reactions. However, few studies have assessed the
Daniel M Muema +7 more
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Cell Reports, 2020 Summary: Within lymph nodes (LNs), T follicular helper (TFH) cells help B cells to produce antibodies, which can either be protective or autoreactive. Here, we demonstrate that murine LN stromal cells (LNSCs) suppress the formation of autoreactive TFH ...
Reza Nadafi +10 more
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T Follicular Helper Cells and B Cell Dysfunction in Aging and HIV-1 Infection
Frontiers in Immunology, 2017 T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory ...
Suresh Pallikkuth +3 more
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Signaling Pathways in T Follicular Helper Cells [PDF]
The Journal of Immunology, 2010 Abstract Th cell functional subsets have unique transcriptional programs that form the molecular basis for T cell differentiation and functions. T follicular helper (TFH) cells have emerged as the main providers of T cell help to B cells during the germinal center (GC) reaction, where B cells undergo selection events through ...
Julia, Rolf +2 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Cell Reports, 2020 Summary: T follicular helper (Tfh) cells are fundamental for B cell selection and antibody maturation in germinal centers. Circulating Tfh (cTfh) cells constitute a minor proportion of the CD4+ T cells in peripheral blood, but their clonotypic ...
Elena Brenna +13 more
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Life of T Follicular Helper Cells
Molecules and Cells, 2015 Antibodies are powerful defense tools against pathogens but may cause autoimmune diseases when erroneously directed toward self-antigens. Thus, antibody producing cells are carefully selected, refined, and expanded in a highly regulated microenvironment (germinal center) in the peripheral lymphoid organs.
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