Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]
, 2016 Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo +14 more
core +1 more source
Signaling Pathways in T Follicular Helper Cells [PDF]
The Journal of Immunology, 2010 Abstract Th cell functional subsets have unique transcriptional programs that form the molecular basis for T cell differentiation and functions. T follicular helper (TFH) cells have emerged as the main providers of T cell help to B cells during the germinal center (GC) reaction, where B cells undergo selection events through competition ...
Julia, Rolf +2 more
openaire +2 more sources
Advances in the role of follicular T helper cells in graft versus host diseases
Liver Research, 2017 Graft versus host disease (GVHD) is a refractory complication of allogeneic hematopoietic stem cell transplantation for the treatment of malignant and non-malignant hematopoietic diseases.
Maogen Chen +4 more
doaj +1 more source
T Follicular Helper Cell Heterogeneity
Annual Review of ImmunologyT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory.
Wenzhi, Song, Joe, Craft
openaire +2 more sources
Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center
Cell Reports, 2017 Summary: Follicular T helper (TFH) cells orchestrate the germinal center (GC) response locally. TFH localization in GCs is controlled by chemo-guidance cues and antigen-specific adhesion. Here.
Hu Yan +13 more
doaj +1 more source
Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice [PDF]
, 2016 Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper antibody production, and a specialized subset of regulatory T cells, follicular regulatory T (Tfr) cells, modulate this process.
Chen, Yuxin +7 more
core +1 more source
Follicular Helper T Cells: Lineage and Location [PDF]
Immunity, 2009 Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-wise development of antigen-specific B cell immunity in vivo. Deployment of CXCR5+ Tfh cells to B cell zones of lymphoid tissues and stable cognate interactions with B cells are central to the delivery of antigen-specific Tfh cell function.
Fazilleau, Nicolas +3 more
openaire +2 more sources
Regulatory T cell-mediated control of chronic inflammation
Frontiers in Immunology, 2012 Autoimmune inflammation including autoantibody-mediated inflammation is responsible for the lethal organ damage that occurs during autoimmune diseases.
Keishi eFujio +3 more
doaj +1 more source
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 [PDF]
, 2014 During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression
Brüstle, Anne +12 more
core +1 more source
T follicular helper and T follicular regulatory cells have different TCR specificity
Nature Communications, 2017 T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear.
Ana Raquel Maceiras +9 more
doaj +1 more source