Results 51 to 60 of about 42,818 (256)

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

Follicular helper T cells in immune homeostasis [PDF]

Cellular & Molecular Immunology, 2012
In recent years, follicular helper T (TFH) cells have become a hot topic for immunologists due to their pivotal role in modulating antibody-mediated immune responses. Although helper T (TH) 2 cells have long been known to provide help for B-cell responses, TFH cells have been identified only recently as a distinct lineage of TH cells that is specific ...
openaire   +2 more sources

Dysregulation of T Follicular Helper Cells in Lupus [PDF]

The Journal of Immunology, 2019
Abstract Although multiple and overlapping mechanisms are ultimately responsible for the immunopathology observed in patients with systemic lupus erythematosus, autoreactive Abs secreted by autoreactive plasma cells (PCs) are considered to play a critical role in disease progression and immunopathology.
John D Mountz, Hui-Chen Hsu, Andre Ballesteros-Tato   +2 more
openaire   +2 more sources

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Follicular Helper T Cells in Systemic Lupus Erythematosus

Frontiers in Immunology, 2018
CD4+ follicular helper T (Tfh) cells constitute a subset of effector T cells that participate in the generation of high-affinity humoral responses. They express the chemokine receptor CXCR5 and produce the cytokine IL-21, both of which are required for ...
Sun Jung Kim, Kyungwoo Lee, Betty Diamond   +2 more
doaj   +1 more source

MicroRNAs, T follicular helper cells and inflammaging

Oncotarget, 2015
Advanced age is associated with a declining ability to mount satisfactory immune responses (i.e. immunosenescence) resulting in increased infection susceptibility and diminished vaccine-elicited immune responses. Paradoxically, aged individuals also have a reduced ability to resolve certain types of inflammation (i.e.
Jason E, Hawkes, Ryan M, O'Connell
openaire   +2 more sources

CD4 T follicular helper cells in HIV    

, 2022
HIV infects millions of individuals worldwide, and new things still emerge. Once infected, the virus cannot be cleared by the system and causes non-heritable immunological disorder syndrome. Combination antiretroviral therapeutic program effectively suppresses microorganism replication and halts malady progression.
Cebo,Daniel, Weiss,Jochen, Dimity,Carolina   +2 more
openaire   +1 more source

Blood Relatives of Follicular Helper T Cells [PDF]

Immunity, 2011
Expression of the chemokine receptor CXCR5 identifies B follicular helper T cells. In this issue of Immunity, Morita et al. (2011) describe a heterogeneous circulating CXCR5(+)CD4(+) B cell helper population overrepresented in juvenile dermatomyositis patients.
Garcia De Vinuesa, Maria Carola, Cook, Matthew   +1 more
openaire   +3 more sources

At Home Detection of Ovarian Health Biomarker in Menstruation Blood

Advanced Materials Technologies, EarlyView.
A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon, Thomas Rduch, Salma Sherif Azer, Inge K. Herrmann   +3 more
wiley   +1 more source

Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity

Cell Reports, 2017
Summary: Effector T cells exhibiting features of either T helper 1 (Th1) or T follicular helper (Tfh) populations are essential to control experimental Plasmodium infection and are believed to be critical for resistance to clinical malaria.
Ryan A. Zander, Rahul Vijay, Angela D. Pack, Jenna J. Guthmiller, Amy C. Graham, Scott E. Lindner, Ashley M. Vaughan, Stefan H.I. Kappe, Noah S. Butler   +8 more
doaj   +1 more source