Results 71 to 80 of about 13,929,929 (284)

Advances in the role of helper T cells in autoimmune diseases

Chinese Medical Journal, 2020
. Autoimmune diseases are primary immune diseases in which autoreactive antibodies or sensitized lymphocytes destroy and damage tissue and cellular components, resulting in tissue damage and organ dysfunction.
Xiao-Mei Zhang, Chun-Yan Liu, Zong-Hong Shao, Li-Shao Guo   +3 more
doaj   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Follicular Helper T Cells in Immunity and Autoimmunity

, 2020
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.

core   +2 more sources

ICOS controls Foxp3+ regulatory T-cell expansion, maintenance, and IL-10 production during helminth infection [PDF]

, 2012
Foxp3+ regulatory T (Treg) cells are key immune regulators during helminth infections, and identifying the mechanisms governing their induction is of principal importance for the design of treatments for helminth infections, allergies and autoimmunity ...
van der Werf, Nienke, MacDonald, Andrew, Redpath, Stephen A, Taylor, Matthew, Cervera, Ana M, Macdonald, Andrew S; id_orcid, Cervera, Ana, Taylor, Matthew D., Maizels, Rick M, Andrew S. MacDonald, Cervera, Ana M., Gray, David, Maizels, Rick, Stephen A. Redpath, Maizels, Rick M., Taylor, Matthew D, Macdonald, Andrew S.; id_orcid, Redpath, Stephen A., Matthew D. Taylor, Rick M. Maizels, David Gray, Nienke van der Werf, Ana M. Cervera   +22 more
core   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Control of Germinal Center Responses by T-Follicular Regulatory Cells

Frontiers in Immunology, 2018
Regulatory T-cells (Treg cells), expressing the transcription factor Foxp3, have an essential role in the control of immune homeostasis. In order to control diverse types of immune responses Treg cells must themselves show functional heterogeneity to ...
James B. Wing, Murat Tekgüç, Shimon Sakaguchi, Shimon Sakaguchi   +3 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells

Cell Reports Medicine, 2020
Summary: Follicular helper T cells (TFH) are critical for vaccine and infection elicitation of long-lived humoral immunity, but exaggerated TFH responses can promote autoimmunity and other pathologies.
Seth D. Reighard, Stacey A. Cranert, Kelly M. Rangel, Ayad Ali, Ivayla E. Gyurova, Arthur T. de la Cruz-Lynch, Jasmine A. Tuazon, Marat V. Khodoun, Leah C. Kottyan, David F. Smith, Hermine I. Brunner, Stephen N. Waggoner   +11 more
doaj   +1 more source

Follicular helper T cells in immune homeostasis [PDF]

Cellular & Molecular Immunology, 2012
In recent years, follicular helper T (TFH) cells have become a hot topic for immunologists due to their pivotal role in modulating antibody-mediated immune responses. Although helper T (TH) 2 cells have long been known to provide help for B-cell responses, TFH cells have been identified only recently as a distinct lineage of TH cells that is specific ...
openaire   +2 more sources