Results 91 to 100 of about 14,832,680 (288)

MicroRNAs, T follicular helper cells and inflammaging

Oncotarget, 2015
Advanced age is associated with a declining ability to mount satisfactory immune responses (i.e. immunosenescence) resulting in increased infection susceptibility and diminished vaccine-elicited immune responses. Paradoxically, aged individuals also have a reduced ability to resolve certain types of inflammation (i.e.
Jason E, Hawkes, Ryan M, O'Connell
openaire   +2 more sources

Priming of T follicular helper cells by dendritic cells [PDF]

Immunology & Cell Biology, 2013
T follicular helper cells (Tfh) are required to generate long‐lived antibody responses, which confer long‐term protection to pathogens following vaccination or infection. Despite significant advances in the field, however, little is known about the early steps that drive Tfh cell differentiation.
André, Ballesteros-Tato, Troy D, Randall   +1 more
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Development and function of follicular helper T cells

Bioscience, Biotechnology, and Biochemistry, 2016
AbstractMost currently available vaccines rely on the induction of long-lasting protective humoral immune responses by memory B cells and plasma cells. Antibody responses against most antigens require interactions between antigen-specific B cells and CD4+ T cells. Follicular helper T cells (TFH cells) are specialized subset of T cells that provide help
openaire   +2 more sources

Follicular B helper T cells in antibody responses and autoimmunity

, 2015
T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer.
Garcia De Vinuesa, Maria Carola, Mackay, Charles R, Moser, Bernhard, Tangye, Stuart G   +3 more
core   +1 more source

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source

Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells

Cell Reports Medicine, 2020
Summary: Follicular helper T cells (TFH) are critical for vaccine and infection elicitation of long-lived humoral immunity, but exaggerated TFH responses can promote autoimmunity and other pathologies.
Seth D. Reighard, Stacey A. Cranert, Kelly M. Rangel, Ayad Ali, Ivayla E. Gyurova, Arthur T. de la Cruz-Lynch, Jasmine A. Tuazon, Marat V. Khodoun, Leah C. Kottyan, David F. Smith, Hermine I. Brunner, Stephen N. Waggoner   +11 more
doaj   +1 more source

Altered Phenotypes of Colonic and Peripheral Blood Follicular Helper and Follicular Cytotoxic T Cells in Mice with DSS-Induced Colitis

, 2023
Yan Long, Chang-Sheng Xia, Xingyue Zeng, Jinghong Feng, Yinting Ma, Chen Liu Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yan Long; Chen Liu, Department of Clinical Laboratory,
Feng J, Long Y, Ma Y, Zeng X, Liu C, Xia CS   +5 more
core  

Foxp3+ follicular regulatory T cells control the germinal center response [PDF]

, 2011
Follicular helper (TFH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of TFH numbers maintains self tolerance.
Beaton, Laura, Fagarasan, Sidonia, Kallies, Axel, Smith, Kenneth G.C., Linterman, Michelle A., Divekar, Devina P., Kawamoto, Shimpei, Srivastava, Monika, Pierson, Wim, Lee, Sau K., Liston, Adrian, Hogan, Jennifer J., Rayner, Tim F., Vinuesa, Carola G.   +13 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source