Results 1 to 10 of about 67,870 (201)
T follicular helper cells and T follicular regulatory cells in autoimmune diseases [PDF]
Frontiers in Immunology, 2023 T follicular helper (Tfh) cells are heterogeneous and mainly characterized by expressing surface markers CXCR5, ICOS, and PD-1; cytokine IL-21; and transcription factor Bcl6.
Jingjing Qi +4 more
doaj +4 more sources
Memory T follicular helper CD4 T cells [PDF]
Frontiers in Immunology, 2015 T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity.
J. Scott eHale, Rafi eAhmed
doaj +3 more sources
Immune surveillance and humoral immune responses in kidney transplantation – A look back at T follicular helper cells [PDF]
Frontiers in Immunology, 2023 T follicular helper cells comprise a specialized, heterogeneous subset of immune-competent T helper cells capable of influencing B cell responses in lymphoid tissues.
Julien Subburayalu +2 more
doaj +2 more sources
Human follicular helper T lymphocytes critical players in antibody responses
Einstein (São Paulo), 2021 Follicular helper T lymphocytes are a subpopulation of CD4+ T lymphocytes initially identified in germinal centers of follicles found in secondary lymphoid organs. The primary function of follicular helper T lymphocytes is to help B lymphocytes’ antibody
Giovana Toledo Alonso +2 more
doaj +2 more sources
Hemato, 2022 Follicular helper T-cell (TFH) lymphomas comprise a unique group of T-cell lymphomas that represent neoplastic proliferations of follicular helper T-cells and share genetic, immunophenotypic, morphologic, and clinical features.
Karthik A. Ganapathi +2 more
doaj +1 more source
TFH cells in systemic sclerosis
Journal of Translational Medicine, 2021 Systemic sclerosis is an autoimmune disease characterized by excessive dermal fibrosis with progression to internal organs, vascular impairment and immune dysregulation evidenced by the infiltration of inflammatory cells in affected tissues and the ...
Pauline Beurier +8 more
doaj +1 more source
Plasticity within the αβ+CD4+ T-cell lineage: when, how and what for? [PDF]
Open Biology, 2013 Following thymic output, αβ+CD4+ T cells become activated in the periphery when they encounter peptide–major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages ...
Stephanie M. Coomes +2 more
doaj +1 more source
PU.1 expression in T follicular helper cells limits CD40L-dependent germinal center B cell development. [PDF]
, 2015 PU.1 is an ETS family transcription factor important for the development of multiple hematopoietic cell lineages. Previous work demonstrated a critical role for PU.1 in promoting Th9 development, and in limiting Th2 cytokine production. Whether PU.1 has
Awe, Olufolakemi +7 more
core +1 more source
Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]
, 2020 Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
core +2 more sources
Haematologica, 2015 T follicular helper cells are the main CD4+ T cells specialized in supporting B-cell responses, but their role in driving transfusion-associated alloimmunization is not fully characterized.
Emmanuelle Godefroy +4 more
doaj +1 more source