Results 21 to 30 of about 42,893 (255)

Immunological mechanism of IgG4-related disease

Journal of Translational Autoimmunity, 2020
IgG4-related disease (IgG4-RD) is an immune-mediated inflammatory disorder in multiple organs, characterized by abundant infiltration of IgG4-positive plasmacytes and fibrosis in the involved organs.
Changyan Liu, Panpan Zhang, Wen Zhang
doaj   +1 more source

Regulation of IgE by T follicular helper cells

Journal of Leukocyte Biology, 2020
Abstract Allergies to food and environmental antigens have steeply grown to epidemic proportions. IgE antibodies are key mediators of allergic disease, including life-threatening anaphylaxis. There is now compelling evidence that one of the hallmarks of anaphylaxis-inducing IgE molecules is their high affinity for allergen, and the ...
Uthaman Gowthaman, Jennifer S. Chen, Stephanie C. Eisenbarth   +2 more
openaire   +3 more sources

Characterization of T Follicular Helper Cells and T Follicular Regulatory Cells in HIV-Infected and Sero-Negative Individuals

Cells, 2023
Humoral immune response is important in fighting pathogens by the production of specific antibodies by B cells. In germinal centers, T follicular helper (TFH) cells provide important help to B-cell antibody production but also contribute to HIV ...
Bradley Salvatore, Rachel S. Resop, Brent R. Gordon, Marta Epeldegui, Otoniel Martinez-Maza, Begoña Comin-Anduix, Alex Lam, Ting-Ting Wu, Christel H. Uittenbogaart   +8 more
doaj   +1 more source

Advances in the role of follicular T helper cells in graft versus host diseases

Liver Research, 2017
Graft versus host disease (GVHD) is a refractory complication of allogeneic hematopoietic stem cell transplantation for the treatment of malignant and non-malignant hematopoietic diseases.
Maogen Chen, Xiaohong Lin, Julie Wang, Nancy Olsen, Song Guo Zheng   +4 more
doaj   +1 more source

Follicular helper T cell in immunity and autoimmunity [PDF]

Brazilian Journal of Medical and Biological Research, 2016
The traditional concept that effector T helper (Th) responses are mediated by Th1/Th2 cell subtypes has been broadened by the recent demonstration of two new effector T helper cells, the IL-17 producing cells (Th17) and the follicular helper T cells (Tfh).
Mesquita Jr, D., Cruvinel, W.M., Resende, L.S., Mesquita, F.V., Silva, N.P., Câmara, N.O.S., Andrade, L.E.C.   +6 more
openaire   +6 more sources

Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center

Cell Reports, 2017
Summary: Follicular T helper (TFH) cells orchestrate the germinal center (GC) response locally. TFH localization in GCs is controlled by chemo-guidance cues and antigen-specific adhesion. Here.
Hu Yan, Longyan Wu, Changming Shih, Shiyue Hou, Jingwen Shi, Tianyang Mao, Wenbin Chen, Bhavani Melvin, Robert J. Rigby, Yingjia Chen, Haochen Jiang, Roland H. Friedel, Carola G. Vinuesa, Hai Qi   +13 more
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Follicular regulatory T cells eliminate HIV-1-infected follicular helper T cells in an IL-2 concentration dependent manner

Frontiers in Immunology, 2022
Follicular helper CD4+ T cells (TFH) are highly permissive to HIV and major foci of virus expression in both untreated and treated infection. Follicular regulatory CD4+ T cells (TFR) limit TFH numbers and function in vitro and in vivo.
Matthew T. Ollerton, Joy M. Folkvord, Andriana La Mantia, David A. Parry, Amie L. Meditz, Martin D. McCarter, Richard T. D’Aquila, Elizabeth Connick   +7 more
doaj   +1 more source

T follicular helper and T follicular regulatory cells have different TCR specificity

Nature Communications, 2017
T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear.
Ana Raquel Maceiras, Silvia Cristina Paiva Almeida, Encarnita Mariotti-Ferrandiz, Wahiba Chaara, Fadi Jebbawi, Adrien Six, Shohei Hori, David Klatzmann, Jose Faro, Luis Graca   +9 more
doaj   +1 more source

Regulatory T cell-mediated control of chronic inflammation

Frontiers in Immunology, 2012
Autoimmune inflammation including autoantibody-mediated inflammation is responsible for the lethal organ damage that occurs during autoimmune diseases.
Keishi eFujio, Tomohisa eOkamura, Shuji eSumitomo, Kazuhiko eYamamoto   +3 more
doaj   +1 more source

Proportions of circulating follicular helper T cells are reduced and correlate with memory B cells in HIV-infected children.

PLoS ONE, 2017
IntroductionHIV causes defects in memory B cells in children, but the mechanisms of those defects have not been fully elucidated. One possible mechanism is the lack of T-cell help to B cells during immune reactions. However, few studies have assessed the
Daniel M Muema, Gladys N Macharia, Babatunde A Olusola, Amin S Hassan, Greg W Fegan, James A Berkley, Britta C Urban, Eunice W Nduati   +7 more
doaj   +1 more source