Results 21 to 30 of about 67,870 (201)

Stat3 Is Important for Follicular Regulatory T Cell Differentiation [PDF]

, 2016
The production of antibody is precisely controlled during the germinal center (GC) reaction. This process is dependent on the help from follicular T helper (Tfh) cells to germinal center (GC) B cells and is regulated by regulatory follicular T helper ...
Dent, Alexander, Liu, Hong, Wu, Hao, Xie, Markus M.   +3 more
core   +3 more sources

Proinflammatory follicular helper T cells promote immunoglobulin G secretion, suppress regulatory B cell development, and correlate with worse clinical outcomes in gastric cancer

Tumor Biology, 2017
Gastric cancer is one of the most common and aggressive malignancies. Both bacterial virulence factors and host chronic inflammation are thought to promote gastric cancer development. In this study, we investigated the potential involvement of follicular
Hong Zhang, Rongxi Yue, Pengfei Zhao, Xuetao Yu, Junguo Li, Guoqing Ma, Jiahong Tang, Lixin Zhang, Liying Feng, Lidong Sun, Zongchang Song, Chunliang Guo, Ning Wang   +12 more
doaj   +1 more source

Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]

, 2017
IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri, Dent, Alexander L., Hummel, Sarah A., Janga, Sarath Chandra, Kaplan, Mark H., Khan, Ibrahim, Meuris, Brice, Olson, Matthew R., Ulrich, Benjamin J.   +8 more
core   +1 more source

The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection. [PDF]

PLoS Pathogens, 2018
CD4 T cell-mediated help to CD8 T cells and B cells is a critical arm of the adaptive immune system required for control of pathogen infection. CD4 T cells express cytokines and co-stimulatory molecules that support a sustained CD8 T cell response and ...
Saravanan Raju, Kohei Kometani, Tomohiro Kurosaki, Andrey S Shaw, Takeshi Egawa   +4 more
doaj   +1 more source

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection [PDF]

, 2016
Funding: This work was funded by a Career Development Fellowship (1028634) and a project grant (GRNT1028641) awarded to AHa by the Australian National Health & Medical Research Council (NHMRC).
A Haque, A Haque, A Haque, A Le Bon, A Pratama, A Pratama, A Sabchareon, AJ McAdam, Andreas Hutloff, Ashraful Haque, BC Rocha, Bryce S. Thomas, C Aucan, C Li, C Shin, C Voisine, CC Kim, CG Matar, Christian R. Engwerda, CL Edwards, D Baumjohann, D Liu, D Perez-Mazliah, D Yu, DJ Wikenheiser, DK Raj, DS Karunarathne, DS Khoury, EA Ball, EG Findlay, ES Coro, Fabian de Labastida Rivera, Fernando Souza-Fonseca-Guimaraes, FH Amante, FH Amante, Fiona H. Amante, G Jego, G Suss, G Trinchieri, Geoffrey R. Hill, H Akiba, H Cucak, H Ueno, H Veiga-Fernandes, H Xu, HC van der Heyde, Ismail Sebina, J Banchereau, J Langhorne, J Li, JA Harker, JA Harker, JC Hall, JL Grun, JP Ray, JP Weber, JW Leavenworth, K Warnatz, Kylie R. James, L Beattie, LB Ivashkiv, Lily G. Fogg, Lynette Beattie, Marcela Montes de Oca, Marcela Montes de Oca, Maria M. Mota, Mark J. Smyth, Megan S. F. Soon, MJ Boyle, MT White, N Obeng-Adjei, NS Butler, O Dienz, Paul J. Hertzog, PF Yong, RA Seder, RA Zander, S Cohen, S Crotty, S Nakayamada, S Pichyangkul, S Portugal, S Sharma, Shannon E. Best, T von der Weid, V Ryg-Cornejo, YS Choi, YS Choi, YS Choi, Z Su   +89 more
core   +5 more sources

The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination [PDF]

, 2018
Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T cells play a central role in all adaptive immune responses.
Gray, Joshua I., Macleod, Megan K.L., Westerhof, Lotus   +2 more
core   +1 more source

Blood Relatives of Follicular Helper T Cells [PDF]

Immunity, 2011
Expression of the chemokine receptor CXCR5 identifies B follicular helper T cells. In this issue of Immunity, Morita et al. (2011) describe a heterogeneous circulating CXCR5(+)CD4(+) B cell helper population overrepresented in juvenile dermatomyositis patients.
Garcia De Vinuesa, Maria Carola, Cook, Matthew   +1 more
openaire   +3 more sources

Development and function of protective and pathologic memory CD4 T cells [PDF]

, 2015
Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses.
Jaigirdar, Shafqat Ahrar, Macleod, Megan K.L.   +1 more
core   +3 more sources

FACS Staining for Follicular Helper T Cells

Bio-Protocol, 2012
Germinal center is the primary site for B cells to undergo somatic hypermutation and class switching. A recently discovered subset of T cells known as T follicular helper (TFH) cells are essential for germinal center reaction and thus have been the ...
Zheng Liu
doaj   +1 more source

Prognostic information from nonmalignant and malignant lymphocytes in follicular lymphoma in relation to therapy [PDF]

, 2011
Follicular lymphoma is the most common indolent lymphoma. It is composed of centrocytes and centroblasts, residing in follicles that also harbour nonmalignant immune and stroma cells.
Wahlin, Björn Engelbrekt
core   +1 more source