Results 21 to 30 of about 15,025,843 (286)
T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? [PDF]
, 2012 Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F. +5 more
core +4 more sources
Human follicular helper T lymphocytes critical players in antibody responses
Einstein (São Paulo), 2021 Follicular helper T lymphocytes are a subpopulation of CD4+ T lymphocytes initially identified in germinal centers of follicles found in secondary lymphoid organs. The primary function of follicular helper T lymphocytes is to help B lymphocytes’ antibody
Giovana Toledo Alonso +2 more
doaj +2 more sources
T follicular helper cells in cancer
Trends in Cancer, 2023 T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated immune responses. Although the crucial function of these CD4+ T cells in infection and vaccination is well established, their involvement in cancer is only beginning to emerge.
Nicolás Gutiérrez-Melo +1 more
openaire +2 more sources
T Follicular Helper Cells in Transplantation [PDF]
Transplantation, 2016 The recently described T follicular helper (Tfh) cell is required for the production of high affinity antibody. After contact with follicular dendritic cells, Tfh cells move into the germinal centre and provide help to B cells both by direct B cell-T cell interaction and production of IL-21.
Giles Desmond, Walters +1 more
openaire +4 more sources
The dysfunction of T follicular helper cells [PDF]
Current Opinion in HIV and AIDS, 2014 T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and how their functional changes might affect antibody ...
Cubas R, Perreau M
openaire +3 more sources
Early Growth Response genes 2 and 3 play a role in chronic inflammation pathology and are essential for the differentiation of T follicular helper cells [PDF]
, 2015 This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University LondonThe Early Growth Response genes 2 and 3 (Egr2/3) are zinc finger transcription factors that play an important role in the immune system.
Ogbe, Ane Theodora
core +5 more sources
TFH cells in systemic sclerosis
Journal of Translational Medicine, 2021 Systemic sclerosis is an autoimmune disease characterized by excessive dermal fibrosis with progression to internal organs, vascular impairment and immune dysregulation evidenced by the infiltration of inflammatory cells in affected tissues and the ...
Pauline Beurier +8 more
doaj +1 more source
PD-1 and ICOS are coexpressed in T follicular helper cells but define three stages of maturation of T follicular regulatory cells. [PDF]
Sci AdvCopyright © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).Humoral responses
Ribeiro F +9 more
europepmc +2 more sources
T follicular helper cells, T follicular regulatory cells and autoimmunity [PDF]
International Immunology, 2015 Abstract CD4 + T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides help for germinal center (GC) formation, B-cell development and affinity maturation, and immunoglobulin class switching, as an indispensable part of adaptive immunity.
Yangyang, Zhu, Le, Zou, Yun-Cai, Liu
openaire +2 more sources