Results 41 to 50 of about 67,870 (201)

T Follicular Helper Cell Heterogeneity

Annual Review of Immunology
T follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory.
Wenzhi, Song, Joe, Craft
openaire   +2 more sources

Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center

Cell Reports, 2017
Summary: Follicular T helper (TFH) cells orchestrate the germinal center (GC) response locally. TFH localization in GCs is controlled by chemo-guidance cues and antigen-specific adhesion. Here.
Hu Yan, Longyan Wu, Changming Shih, Shiyue Hou, Jingwen Shi, Tianyang Mao, Wenbin Chen, Bhavani Melvin, Robert J. Rigby, Yingjia Chen, Haochen Jiang, Roland H. Friedel, Carola G. Vinuesa, Hai Qi   +13 more
doaj   +1 more source

Follicular regulatory T cells eliminate HIV-1-infected follicular helper T cells in an IL-2 concentration dependent manner

Frontiers in Immunology, 2022
Follicular helper CD4+ T cells (TFH) are highly permissive to HIV and major foci of virus expression in both untreated and treated infection. Follicular regulatory CD4+ T cells (TFR) limit TFH numbers and function in vitro and in vivo.
Matthew T. Ollerton, Joy M. Folkvord, Andriana La Mantia, David A. Parry, Amie L. Meditz, Martin D. McCarter, Richard T. D’Aquila, Elizabeth Connick   +7 more
doaj   +1 more source

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice [PDF]

, 2016
Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper antibody production, and a specialized subset of regulatory T cells, follicular regulatory T (Tfr) cells, modulate this process.
Chen, Yuxin, Dent, Alexander L., Liu, Hong, Lu, Shan, Teuscher, Paula, Wang, Shixia, Wu, Hao, Xu, Lin-Lin   +7 more
core   +1 more source

Follicular Helper T Cells: Lineage and Location [PDF]

Immunity, 2009
Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-wise development of antigen-specific B cell immunity in vivo. Deployment of CXCR5+ Tfh cells to B cell zones of lymphoid tissues and stable cognate interactions with B cells are central to the delivery of antigen-specific Tfh cell function.
Fazilleau, Nicolas, Mark, Linda, McHeyzer-Williams, Louise J., McHeyzer-Williams, Michael G.   +3 more
openaire   +2 more sources

T follicular helper and T follicular regulatory cells have different TCR specificity

Nature Communications, 2017
T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear.
Ana Raquel Maceiras, Silvia Cristina Paiva Almeida, Encarnita Mariotti-Ferrandiz, Wahiba Chaara, Fadi Jebbawi, Adrien Six, Shohei Hori, David Klatzmann, Jose Faro, Luis Graca   +9 more
doaj   +1 more source

Regulatory T cell-mediated control of chronic inflammation

Frontiers in Immunology, 2012
Autoimmune inflammation including autoantibody-mediated inflammation is responsible for the lethal organ damage that occurs during autoimmune diseases.
Keishi eFujio, Tomohisa eOkamura, Shuji eSumitomo, Kazuhiko eYamamoto   +3 more
doaj   +1 more source

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 [PDF]

, 2014
During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression
Brüstle, Anne, Chen, Jonathan H, Cui, Weiguo, Kaech, Susan M, Laidlaw, Brian J, Lang, Philipp A, Marshall, Heather D, Ohashi, Pamela, Parish, Ian A, Perry, Curtis, Staron, Matthew M, Tsui, Yao-Chen, Weaver, Casey T   +12 more
core   +1 more source

Proportions of circulating follicular helper T cells are reduced and correlate with memory B cells in HIV-infected children.

PLoS ONE, 2017
IntroductionHIV causes defects in memory B cells in children, but the mechanisms of those defects have not been fully elucidated. One possible mechanism is the lack of T-cell help to B cells during immune reactions. However, few studies have assessed the
Daniel M Muema, Gladys N Macharia, Babatunde A Olusola, Amin S Hassan, Greg W Fegan, James A Berkley, Britta C Urban, Eunice W Nduati   +7 more
doaj   +1 more source

Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses

Cell Reports, 2020
Summary: Within lymph nodes (LNs), T follicular helper (TFH) cells help B cells to produce antibodies, which can either be protective or autoreactive. Here, we demonstrate that murine LN stromal cells (LNSCs) suppress the formation of autoreactive TFH ...
Reza Nadafi, Catarina Gago de Graça, Eelco D. Keuning, Jasper J. Koning, Sander de Kivit, Tanja Konijn, Sandrine Henri, Jannie Borst, Rogier M. Reijmers, Lisa G.M. van Baarsen, Reina E. Mebius   +10 more
doaj   +1 more source