Results 41 to 50 of about 42,893 (255)

T Follicular Helper Cell Heterogeneity

Annual Review of Immunology
T follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory.
Wenzhi, Song, Joe, Craft
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Follicular Helper T Cells: Lineage and Location [PDF]

Immunity, 2009
Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-wise development of antigen-specific B cell immunity in vivo. Deployment of CXCR5+ Tfh cells to B cell zones of lymphoid tissues and stable cognate interactions with B cells are central to the delivery of antigen-specific Tfh cell function.
Fazilleau, Nicolas, Mark, Linda, McHeyzer-Williams, Louise J., McHeyzer-Williams, Michael G.   +3 more
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

B Cell Help by CD1d-Rectricted NKT Cells

Antibodies, 2015
B cell activation and antibody production against foreign antigens is a central step of host defense. This is achieved via highly regulated multi-phase processes that involve a variety of cells of both innate and adaptive arms of the immune system.
Livia Clerici, Giulia Casorati, Paolo Dellabona   +2 more
doaj   +1 more source

Signaling Pathways in T Follicular Helper Cells [PDF]

The Journal of Immunology, 2010
Abstract Th cell functional subsets have unique transcriptional programs that form the molecular basis for T cell differentiation and functions. T follicular helper (TFH) cells have emerged as the main providers of T cell help to B cells during the germinal center (GC) reaction, where B cells undergo selection events through ...
Julia, Rolf, Kirsten, Fairfax, Martin, Turner   +2 more
openaire   +2 more sources

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

New Territory for T Follicular Helper Cells [PDF]

Immunity, 2013
T follicular helper (Tfh) cells have been thrust into the limelight since the recent discovery of their unique developmental program. Exciting new insights into the regulation of Tfh development, migration, and function were presented at the first Gordon Conference on Tfh cells held in Hong Kong and summarized here.
Vinuesa, Carola, Fagarasan, Sidonia, Dong, Chen   +2 more
openaire   +3 more sources

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Follicular helper T cells in immune homeostasis [PDF]

Cellular & Molecular Immunology, 2012
In recent years, follicular helper T (TFH) cells have become a hot topic for immunologists due to their pivotal role in modulating antibody-mediated immune responses. Although helper T (TH) 2 cells have long been known to provide help for B-cell responses, TFH cells have been identified only recently as a distinct lineage of TH cells that is specific ...
openaire   +2 more sources