Results 51 to 60 of about 67,870 (201)

T Follicular Helper Cells and B Cell Dysfunction in Aging and HIV-1 Infection

Frontiers in Immunology, 2017
T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory ...
Suresh Pallikkuth, Lesley de Armas, Stefano Rinaldi, Savita Pahwa   +3 more
doaj   +1 more source

Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death

Frontiers in Immunology, 2021
Follicular helper T (TFH) cells are specialized CD4+ helper T cells that provide help to B cells in humoral immunity. However, the molecular mechanism underlying generation of TFH cells is incompletely understood.
Lingtao Yang, Wei Chen, Li Li, Yueyue Xiao, Shilin Fan, Quan Zhang, Tian Xia, Mengjie Li, Yazhen Hong, Tongjin Zhao, Qiyuan Li, Wen-Hsien Liu, Nengming Xiao   +12 more
doaj   +1 more source

Microbiota and chronic inflammatory arthritis. an interwoven link [PDF]

, 2016
Background: Only recently, the scientific community gained insights on the importance of the intestinal resident flora for the host's health and disease.
D'Amelio, Raffaele, Laganà, Bruno, Manuela Rosado, M, Picchianti Diamanti, Andrea   +3 more
core   +2 more sources

Mapping the Lineage Relationship between CXCR5+ and CXCR5− CD4+ T Cells in HIV-Infected Human Lymph Nodes

Cell Reports, 2019
Summary: CXCR5 is a key marker of follicular helper T (TFH) cells. Using primary lymph nodes (LNs) from HIV-infected patients, we identified a population of CXCR5− CD4+ T cells with TFH-cell-like features.
Daniel Del Alcazar, Yifeng Wang, Chenfeng He, Ben S. Wendel, Perla M. Del Río-Estrada, Jerome Lin, Yuria Ablanedo-Terrazas, Michael J. Malone, Stefany M. Hernandez, Ian Frank, Ali Naji, Gustavo Reyes-Terán, Ning Jiang, Laura F. Su   +13 more
doaj   +1 more source

CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells

Cell Reports, 2020
Summary: T follicular helper (Tfh) cells are fundamental for B cell selection and antibody maturation in germinal centers. Circulating Tfh (cTfh) cells constitute a minor proportion of the CD4+ T cells in peripheral blood, but their clonotypic ...
Elena Brenna, Alexey N. Davydov, Kristin Ladell, James E. McLaren, Paolo Bonaiuti, Maria Metsger, James D. Ramsden, Sarah C. Gilbert, Teresa Lambe, David A. Price, Suzanne L. Campion, Dmitriy M. Chudakov, Persephone Borrow, Andrew J. McMichael   +13 more
doaj   +1 more source

TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. [PDF]

, 2019
CD4+ Foxp3+ T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties.
Cho, Sunglim, Dong, Yi, Feng, Gen-Sheng, Fu, Wenxian, Jepsen, Kristen, Liang, Yan, Lu, Li-Fan, Wan, Shuo, Wang, Ke, Xu, Wanqing, Xue, Hai-Hui, Yang, Bi-Huei, Yuan, Xiaomei   +12 more
core   +1 more source

Atypical chemokine receptor 4 shapes activated B cell fate [PDF]

, 2018
Activated B cells can initially differentiate into three functionally distinct fates-early plasmablasts (PBs), germinal center (GC) B cells, or early memory B cells-by mechanisms that remain poorly understood.
Alsharifi, Mohammed, Babb, Rachelle, Bastow, Cameron R., Bourne, Katherine, Brink, Robert, Comerford, Iain, Cyster, Jason G., Fenix, Kevin A., Gilchrist, Derek S., Gregor, Carly E., Hermes, Jana R., Hill, Geoffrey R., Kara, Ervin E., McColl, Shaun R., McKenzie, Duncan R., Nibbs, Robert J., Norton, Todd S., Rodda, Lauren B., Tarlinton, David M., Vinuesa, Carola G., Zotos, Dimitra   +20 more
core   +2 more sources

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells [PDF]

, 2013
The transcription factor BATF is required for interleukin 17 (IL-17)-producing helper T cell (TH17) and follicular helper T cell (TFH) differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation.
Barnitz, R. Anthony, Dilorio, Michael A., Godec, Jernej, Haining, W. Nicholas, Klatt, Martin G., Kurachi, Makoto, Lemieux, Madeleine E., Odorizzi, Pamela M., Regev, Aviv, Wherry, E. John, Yates, Kathleen, Yosef, Nir   +11 more
core   +3 more sources

B Cell Help by CD1d-Rectricted NKT Cells

Antibodies, 2015
B cell activation and antibody production against foreign antigens is a central step of host defense. This is achieved via highly regulated multi-phase processes that involve a variety of cells of both innate and adaptive arms of the immune system.
Livia Clerici, Giulia Casorati, Paolo Dellabona   +2 more
doaj   +1 more source

CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance [PDF]

, 2019
Many autoimmune diseases are characterized by the production of autoantibodies. The current view is that CD4+ T follicular helper (Tfh) cells are the main subset regulating autoreactive B cells.
Burns, Robert, Chen, Yuhong, Cui, Weiguo, Dent, Alexander L., Fu, Guoping, Li, Quan-Zhen, Luo, Lan, Malherbe, Laurent, Wang, Demin, Wen, Renren, Xin, Gang, Yu, Mei, Zheng, Yongwei, Zhu, Nan, Zhu, Wen   +14 more
core   +1 more source