Results 61 to 70 of about 15,025,843 (286)

Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases [PDF]

, 2021
The interactions of CD4⁺ T cells and B cells are fundamental for the generation of protective antibody responses, as well as for the development of harmful autoimmune diseases.
Hiroyuki Yoshitomi, Hideki Ueno, Ueno, Hideki, Yoshitomi, Hiroyuki   +3 more
core   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

B Cell Help by CD1d-Rectricted NKT Cells

Antibodies, 2015
B cell activation and antibody production against foreign antigens is a central step of host defense. This is achieved via highly regulated multi-phase processes that involve a variety of cells of both innate and adaptive arms of the immune system.
Livia Clerici, Giulia Casorati, Paolo Dellabona   +2 more
doaj   +1 more source

CD4+ T Follicular Helper Cells in Human Tonsils and Blood Are Clonally Convergent but Divergent from Non-Tfh CD4+ Cells

Cell Reports, 2020
Summary: T follicular helper (Tfh) cells are fundamental for B cell selection and antibody maturation in germinal centers. Circulating Tfh (cTfh) cells constitute a minor proportion of the CD4+ T cells in peripheral blood, but their clonotypic ...
Elena Brenna, Alexey N. Davydov, Kristin Ladell, James E. McLaren, Paolo Bonaiuti, Maria Metsger, James D. Ramsden, Sarah C. Gilbert, Teresa Lambe, David A. Price, Suzanne L. Campion, Dmitriy M. Chudakov, Persephone Borrow, Andrew J. McMichael   +13 more
doaj   +1 more source

Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death

Frontiers in Immunology, 2021
Follicular helper T (TFH) cells are specialized CD4+ helper T cells that provide help to B cells in humoral immunity. However, the molecular mechanism underlying generation of TFH cells is incompletely understood.
Lingtao Yang, Wei Chen, Li Li, Yueyue Xiao, Shilin Fan, Quan Zhang, Tian Xia, Mengjie Li, Yazhen Hong, Tongjin Zhao, Qiyuan Li, Wen-Hsien Liu, Nengming Xiao   +12 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

New Territory for T Follicular Helper Cells [PDF]

Immunity, 2013
T follicular helper (Tfh) cells have been thrust into the limelight since the recent discovery of their unique developmental program. Exciting new insights into the regulation of Tfh development, migration, and function were presented at the first Gordon Conference on Tfh cells held in Hong Kong and summarized here.
Vinuesa, Carola, Fagarasan, Sidonia, Dong, Chen   +2 more
openaire   +3 more sources

Acute Endocrine Alterations After Traumatic Brain Injury and 6‐Month Functional Outcome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Acute multi‐axis endocrine alterations after traumatic brain injury (TBI) remain incompletely characterized. This study aimed to examine their temporal patterns and explore their associations with 6‐month functional outcome and early inflammatory markers.
Biao Xu, Peng Guo, Rui Pan, Zhenghao Wang, Jingchao Zhou, Pengcheng Zhang, Xingzhe Zhang, Qinghua Zhang, Haibin Ma, Zhanfeng Niu   +9 more
wiley   +1 more source

Follicular helper T cells in immune homeostasis [PDF]

Cellular & Molecular Immunology, 2012
In recent years, follicular helper T (TFH) cells have become a hot topic for immunologists due to their pivotal role in modulating antibody-mediated immune responses. Although helper T (TH) 2 cells have long been known to provide help for B-cell responses, TFH cells have been identified only recently as a distinct lineage of TH cells that is specific ...
openaire   +2 more sources