Follicular Regulatory T Cells in Systemic Lupus Erythematosus [PDF]
Journal of Immunology Research, 2021 Follicular regulatory T (Tfr) cells are the regulatory T cell subset mainly localized in the germinal center (GC), acting as modulators of GC responses.
Xin Xia, Jun Yang, Shengjun Wang
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Unexpected Help: Follicular Regulatory T Cells in the Germinal Center [PDF]
Frontiers in Immunology, 2018 Follicular helper T (Tfh) cells are necessary for germinal center (GC) formation and within the GC, provide key signals to B cells for their differentiation into plasmablasts and plasma cells that secrete high-affinity and isotype-switched antibody (Ab).
Markus M. Xie, Alexander L. Dent
doaj +5 more sources
Interleukin-1 in the Response of Follicular Helper and Follicular Regulatory T Cells [PDF]
Frontiers in Immunology, 2019 The role of interleukin-1 in the regulation of humoral responses is poorly documented, in contrast to its role in inflammation. Recent findings suggest there is an interleukin-1 axis in the follicular T cell control of B cell responses, involving ...
Paul-Gydéon Ritvo +2 more
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Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor [PDF]
Cell Reports, 2019 Summary: Follicular regulatory T (TFR) cells are a specialized suppressive subset that controls the germinal center (GC) response and maintains humoral self-tolerance.
Lei Wang +13 more
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Follicular regulatory T cells: a novel target for immunotherapy? [PDF]
Clinical & Translational Immunology, 2020 High‐affinity antibodies are produced during multiple processes in germinal centres (GCs), where follicular helper T (Tfh) cells interact closely with B cells to support B‐cell survival, differentiation and proliferation.
Yao Huang +9 more
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The Imbalance of Circulating Follicular Helper T Cells and Follicular Regulatory T Cells Is Associated With Disease Activity in Patients With Ulcerative Colitis. [PDF]
Front Immunol, 2020 Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the colon and rectum, in which the abnormality of B cells is involved in both its pathogenesis and progression.
Long Y +7 more
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Are Follicular Regulatory T Cells Involved in Autoimmune Diseases? [PDF]
Frontiers in Immunology, 2017 In the germinal center (GC), follicular helper T (TFH) cells interact with B cells and undergo a series of GC reactions to ultimately produce high-affinity antibodies and memory plasma cells.
Yonglu Gong +4 more
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Control of the Germinal Center by Follicular Regulatory T Cells During Infection. [PDF]
Front Immunol, 2018 Follicular regulatory T cells (Tfr) are a unique subset of CD4 T cells that control and impact adaptive immune responses in the lymphoid follicles and germinal centers (GC).
Miles B, Connick E.
europepmc +3 more sources
Aberrant follicular regulatory T cells associate with immunoglobulin hyperproduction in nasal polyps with ectopic lymphoid tissues. [PDF]
J Allergy Clin Immunol, 2023 Background: Ectopic lymphoid tissues (eLTs) and associated follicular helper T (TFH) cells contribute to local immunoglobulin hyperproduction in nasal polyps (NPs). Follicular regulatory T (TFR) cells in secondary lymphoid organs counteract TFH cells and
Song J +11 more
europepmc +2 more sources
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells. [PDF]
Elife, 2023 Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response.
Ke F +6 more
europepmc +2 more sources