Results 1 to 10 of about 14,801,660 (264)

The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia [PDF]

Scientific Reports, 2019
Autoimmune hemolytic anemia (AIHA) is an acquired autoimmune disease mediated by antibodies against the patient’s red blood cells. However, the underlying mechanisms for antibody production are not fully understood.
Yuhan Gao, Haiqiang Jin, Ding Nan, Weiwei Yu, Jianhua Zhang, Ying Yang, Ruiqin Hou, Ranran Qin, Hongjun Hao, Yongan Sun, Wenqin Tian   +10 more
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Follicular Regulatory T Cells in Systemic Lupus Erythematosus [PDF]

Journal of Immunology Research, 2021
Follicular regulatory T (Tfr) cells are the regulatory T cell subset mainly localized in the germinal center (GC), acting as modulators of GC responses.
Xin Xia, Jun Yang, Shengjun Wang
doaj   +3 more sources

Follicular T cells in the ovarian cancer immune microenvironment: biological insights and translational implications [PDF]

Frontiers in Immunology
BackgroundOvarian cancer, particularly high-grade serous ovarian cancer (HGSOC), exhibits a generally poor response to immune checkpoint inhibitors, and its underlying mechanisms remain incompletely defined.
Yidan Xu, Li Li
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Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor

Cell Reports, 2019
Summary: Follicular regulatory T (TFR) cells are a specialized suppressive subset that controls the germinal center (GC) response and maintains humoral self-tolerance.
Lei Wang, Erxia Shen, Lin Luo, Hardis Rabe, Qin Wang, Jie Yin, Xueying Yang, Wenquan Liu, Jessica M. Sido, Hidetoshi Nakagawa, Lin Ao, Hye-Jung Kim, Harvey Cantor, Jianmei W. Leavenworth   +13 more
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BLIMP-1-dependent differentiation of T follicular helper cells into Foxp3+ T regulatory type 1 cells

Frontiers in Immunology
T-regulatory-type-1 (TR1) cells are a subset of interleukin-10-producing but Foxp3– Treg cells that arise in response to chronic antigenic stimulation. We have shown that systemic delivery of autoimmune disease-relevant peptide-major histocompatibility ...
Josep Garnica, Jun Yamanouchi, Robert Clarke, Joel Moro, Shari Thiessen, Javier Montaño, Debajyoti Mondal, Pau Serra, Pere Santamaria, Pere Santamaria   +9 more
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Follicular regulatory T cells eliminate HIV-1-infected follicular helper T cells in an IL-2 concentration dependent manner

Frontiers in Immunology, 2022
Follicular helper CD4+ T cells (TFH) are highly permissive to HIV and major foci of virus expression in both untreated and treated infection. Follicular regulatory CD4+ T cells (TFR) limit TFH numbers and function in vitro and in vivo.
Matthew T. Ollerton, Joy M. Folkvord, Andriana La Mantia, David A. Parry, Amie L. Meditz, Martin D. McCarter, Richard T. D’Aquila, Elizabeth Connick   +7 more
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Highly sensitised individuals present a distinct Treg signature compared to unsensitised individuals on haemodialysis

Frontiers in Transplantation, 2023
IntroductionHighly sensitised (HS) patients represent up to 30% of patients on the kidney transplant waiting list. When they are transplanted, they have a high risk of acute/chronic rejection and long-term allograft loss.
C. Dudreuilh, C. Dudreuilh, S. Basu, S. Basu, O. Shaw, H. Burton, H. Burton, N. Mamode, N. Mamode, F. Harris, T. Tree, P. Nedyalko, M. Terranova-Barberio, G. Lombardi, C. Scottà, A. Dorling, A. Dorling   +16 more
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Altered Distribution of Circulating T Follicular Helper-Like Cell Subsets in Rheumatoid Arthritis Patients

Frontiers in Medicine, 2021
Objective: Recent studies on follicular regulatory T (Tfr) and follicular helper T (Tfh) cells suggest that they may participate in the pathogenesis of rheumatoid arthritis (RA).
Rui Su, Yanyan Wang, Fangyuan Hu, Baochen Li, Qiaoling Guo, Xinyu Zheng, Yue Liu, Chong Gao, Xiaofeng Li, Caihong Wang   +9 more
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Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells

Cell Reports Medicine, 2020
Summary: Follicular helper T cells (TFH) are critical for vaccine and infection elicitation of long-lived humoral immunity, but exaggerated TFH responses can promote autoimmunity and other pathologies.
Seth D. Reighard, Stacey A. Cranert, Kelly M. Rangel, Ayad Ali, Ivayla E. Gyurova, Arthur T. de la Cruz-Lynch, Jasmine A. Tuazon, Marat V. Khodoun, Leah C. Kottyan, David F. Smith, Hermine I. Brunner, Stephen N. Waggoner   +11 more
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Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions

Frontiers in Immunology, 2018
An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to ...
Nicolas Fazilleau, Nicolas Fazilleau, Nicolas Fazilleau, Nicolas Fazilleau, Meryem Aloulou, Meryem Aloulou, Meryem Aloulou, Meryem Aloulou   +7 more
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