T follicular helper and T follicular regulatory cells have different TCR specificity [PDF]
Nature Communications, 2017 T follicular helper and regulatory cells are generated in the germinal centre; however, whether antigen specificity defines their differential functions is unclear.
Ana Raquel Maceiras +9 more
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T follicular helper cells and T follicular regulatory cells in autoimmune diseases [PDF]
Frontiers in Immunology, 2023 T follicular helper (Tfh) cells are heterogeneous and mainly characterized by expressing surface markers CXCR5, ICOS, and PD-1; cytokine IL-21; and transcription factor Bcl6.
Jingjing Qi +4 more
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CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells [PDF]
Frontiers in Immunology, 2023 IntroductionGermline CARD11 gain-of-function (GOF) mutations cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell
Etienne Masle-Farquhar +13 more
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Characterization of T Follicular Helper Cells and T Follicular Regulatory Cells in HIV-Infected and Sero-Negative Individuals [PDF]
Cells, 2023 Humoral immune response is important in fighting pathogens by the production of specific antibodies by B cells. In germinal centers, T follicular helper (TFH) cells provide important help to B-cell antibody production but also contribute to HIV ...
Bradley Salvatore +8 more
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Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases [PDF]
Inflammation and Regeneration, 2021 T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation.
He Hao +2 more
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T Follicular Regulatory Cells: Choreographers of Productive Germinal Center Responses [PDF]
Frontiers in Immunology, 2021 T follicular regulatory cells, or Tfr cells, are a discernable population of regulatory T (Treg) cells that migrate to the B cell follicle and germinal center (GC) upon immune challenge.
Yisi Lu, Joe Craft, Joe Craft
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Control of Germinal Center Responses by T-Follicular Regulatory Cells [PDF]
Frontiers in Immunology, 2018 Regulatory T-cells (Treg cells), expressing the transcription factor Foxp3, have an essential role in the control of immune homeostasis. In order to control diverse types of immune responses Treg cells must themselves show functional heterogeneity to ...
James B. Wing +3 more
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Higher frequency of circulating regulatory T cells is associated with poor outcomes in patients with colorectal cancer [PDF]
Discover OncologyBackground While immune dysregulation significantly influences colorectal cancer (CRC) progression, this study aimed to investigate the levels of circulating regulatory T cells (cTreg) and their subsets, follicular helper T cells (cTfh), and follicular ...
Yan Lu +4 more
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Imbalance of Circulatory T Follicular Helper and T Follicular Regulatory Cells in Patients with ANCA-Associated Vasculitis [PDF]
Mediators of Inflammation, 2019 Antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is characterized by small-vessel inflammation in association with autoantibodies. Balance between T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells is critical
Ying Xu +8 more
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The Role of T Follicular Helper Cells and T Follicular Regulatory Cells in the Pathogenesis of Autoimmune Hemolytic Anemia [PDF]
Scientific Reports, 2019 Autoimmune hemolytic anemia (AIHA) is an acquired autoimmune disease mediated by antibodies against the patient’s red blood cells. However, the underlying mechanisms for antibody production are not fully understood.
Yuhan Gao +10 more
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