Antibody Mediated Intercommunication of Germinal Centers [PDF]
Cells, 2022 Antibody diversification and selection of B cells occur in dynamic structures called germinal centers (GCs). Passively administered soluble antibodies regulate the GC response by masking the antigen displayed on follicular dendritic cells (FDCs).
Theinmozhi Arulraj +2 more
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Germinal centers are permissive to subdominant antibody responses [PDF]
Frontiers in Immunology, 2023 IntroductionA protective humoral response to pathogens requires the development of high affinity antibodies in germinal centers (GC). The combination of antigens available during immunization has a strong impact on the strength and breadth of the ...
Philippe A. Robert +5 more
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Protocol to Isolate Germinal Centers by Laser Microdissection [PDF]
Bio-Protocol, 2022 During adaptive immune responses, germinal centers (GC) appear as transient microstructures, in which antigen-specific B and T cells interact with each other.
Farbod Bahreini +4 more
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Immunoglobulin VDJ repertoires reveal hallmarks of germinal centers in unique cell clusters isolated from zebrafish (Danio rerio) lymphoid tissues [PDF]
Frontiers in Immunology, 2022 DNA mutagenesis during antibody affinity maturation has potentially oncogenic or autoimmune outcomes if not tightly controlled as it is in mammalian germinal centers.
Doaa Waly +4 more
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Unsupervised Clustering of Cell Populations in Germinal Centers Using Multiplexed Immunofluorescence [PDF]
BiologyFollicles (Fs)/Germinal Centers (GCs) in tonsils and lymph nodes are dynamic microenvironments where diverse immune cell populations interact for the development of antibody responses against pathogens.
Simon Burgermeister +8 more
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Chronic Generalized Lymphadenopathy in a Child—Progressive Transformation of Germinal Centers (PTGC) [PDF]
Children, 2022 Background: Enlarged lymph nodes are a common complaint in a Pediatrician’s office. Diagnosis of reactive lymphadenopathy secondary to infectious, inflammatory, immune dysregulation calls for clinical investigation, including a thorough history, physical
Carson Wills +4 more
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Acute SIV infection in sooty mangabey monkeys is characterized by rapid virus clearance from lymph nodes and absence of productive infection in germinal centers. [PDF]
PLoS ONE, 2013 Lymphoid tissue immunopathology is a characteristic feature of chronic HIV/SIV infection in AIDS-susceptible species, but is absent in SIV-infected natural hosts.
Amanda J Martinot +9 more
doaj +6 more sources
DNA immunisation. New histochemical and morphometric data [PDF]
European Journal of Histochemistry, 2010 Splenic germinal center reactions were measured during primary response to a plasmidic DNA intramuscular injection. Cardiotoxin-pretreated Balb/c mice were immunized with DNA plasmids encoding or not the SAG1 protein, a membrane antigen of Toxoplasma ...
D Ehirchiou +10 more
doaj +2 more sources
Frontiers in Immunology, 2023 A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg +5 more
doaj +1 more source
İstanbul Tıp Fakültesi Dergisi, 2022 Objective: The aim of the study is to assess local immune activation through B lymphocytes density and the presence of germinal centers in the vestibular mucosa of patients with localized provoked vulvodynia (LPV).
İrem Demiral Keleş +5 more
doaj +1 more source