Results 1 to 10 of about 26,681 (151)
Spontaneous germinal centers and autoimmunity [PDF]
Autoimmunity, 2017 Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response.
Phillip P. Domeier +2 more
doaj +4 more sources
Antibody Mediated Intercommunication of Germinal Centers [PDF]
Cells, 2022 Antibody diversification and selection of B cells occur in dynamic structures called germinal centers (GCs). Passively administered soluble antibodies regulate the GC response by masking the antigen displayed on follicular dendritic cells (FDCs).
Theinmozhi Arulraj +2 more
doaj +2 more sources
Germinal centers are permissive to subdominant antibody responses [PDF]
Frontiers in Immunology, 2023 IntroductionA protective humoral response to pathogens requires the development of high affinity antibodies in germinal centers (GC). The combination of antigens available during immunization has a strong impact on the strength and breadth of the ...
Philippe A. Robert +5 more
doaj +2 more sources
Protocol to Isolate Germinal Centers by Laser Microdissection [PDF]
Bio-Protocol, 2022 During adaptive immune responses, germinal centers (GC) appear as transient microstructures, in which antigen-specific B and T cells interact with each other.
Farbod Bahreini +4 more
doaj +2 more sources
Annual Review of Immunology, 2012 Germinal centers (GCs) were described more than 125 years ago as compartments within secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that this structure is the site of B cell clonal expansion, somatic hypermutation, and affinity-based selection, the combination of which results in the production of high-affinity ...
Gabriel Victora, Michel Nussenzweig
exaly +5 more sources
Unsupervised Clustering of Cell Populations in Germinal Centers Using Multiplexed Immunofluorescence [PDF]
BiologyFollicles (Fs)/Germinal Centers (GCs) in tonsils and lymph nodes are dynamic microenvironments where diverse immune cell populations interact for the development of antibody responses against pathogens.
Simon Burgermeister +8 more
doaj +2 more sources
Cell Reports, 2020 Summary: It is unknown whether the incremental increases in BCL6 amounts in antigen-activated B cells influence the unfolding differentiation before germinal center (GC) formation.
Marcus James Robinson +6 more
doaj +3 more sources
Chronic Generalized Lymphadenopathy in a Child—Progressive Transformation of Germinal Centers (PTGC) [PDF]
Children, 2022 Background: Enlarged lymph nodes are a common complaint in a Pediatrician’s office. Diagnosis of reactive lymphadenopathy secondary to infectious, inflammatory, immune dysregulation calls for clinical investigation, including a thorough history, physical
Carson Wills +4 more
doaj +2 more sources
Molecular Systems Biology, 2010 Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of ...
Celine Lefebvre +15 more
doaj +2 more sources
Tfh1 Cells in Germinal Centers During Chronic HIV/SIV Infection
Frontiers in Immunology, 2018 T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of germinal center (GC) reactions, a critical process that promotes the generation of long-lived high affinity humoral immunity.
Vijayakumar Velu +6 more
doaj +3 more sources