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Regulation of the Germinal Center Response [PDF]
Frontiers in Immunology, 2018 The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection.
Marisa Stebegg +8 more
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PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma
The Journal of Clinical Investigation, 2022 The synthesis of serine from glucose is a key metabolic pathway supporting cellular proliferation in healthy and malignant cells. Despite this, the role that this aspect of metabolism plays in germinal center biology and pathology is not known.
Annalisa D’Avola +16 more
doaj +2 more sources
Immunity, 2020 The deployment of effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to eradicate the coronavirus disease 2019 (COVID-19) pandemic.
Daniela Gomez Atria +2 more
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Positive selection of IgG+ over IgM+ B cells in the germinal center reaction
Immunity, 2021 Positive selection of high-affinity B cells within germinal centers (GCs) drives affinity maturation of antibody responses. Here, we examined the mechanism underlying the parallel transition from immunoglobulin M (IgM) to IgG.
, Dan Suan
exaly +2 more sources
Germinal Center Optimization Algorithm [PDF]
International Journal of Computational Intelligence Systems, 2018 Artificial immune systems are metaheuristic algorithms that mimic the adaptive capabilities of the immune system of vertebrates. Since the 1990s, they have become one of the main branches of computer intelligence.
Carlos Villaseñor +4 more
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Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity
Immunity, 2019 Summary High affinity B cell selection in the germinal center (GC) is governed by signals delivered by follicular helper T cells (Tfh) to B cells. Selected B cells undergo clonal expansion and affinity maturation in the GC dark zone in direct proportion ...
Harald Hartweger +2 more
exaly +2 more sources
Cytokines in the Germinal Center Niche [PDF]
Antibodies, 2016 Cytokines are small, secreted, glycoproteins that specifically affect the interactions and communications between cells. Cytokines are produced transiently and locally, acting in a paracrine or autocrine manner, and they are extremely potent, ligating ...
Christoph Jandl, Cecile King
doaj +4 more sources
Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
Immunity, 2017 Summary During antibody affinity maturation, germinal center (GC) B cells cycle between affinity‐driven selection in the light zone (LZ) and proliferation and somatic hypermutation in the dark zone (DZ).
Gabriel Victora +2 more
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Immunity, 2018 Summary Positive selection of germinal center (GC) B cells is driven by B cell receptor (BCR) affinity and requires help from follicular T helper cells. The transcription factors c‐Myc and Foxo1 are critical for GC B cell selection and survival. However,
Mark Shlomchik +2 more
exaly +2 more sources
Gammaherpesvirus infection unveils exaggerated germinal center responses in an SR-BI-deficient host [PDF]
Journal of VirologyLipid metabolism has emerged as an important regulator of acute viral infections by affecting viral replication and the host immune response. In contrast, the role of host lipid metabolism during chronic viral infection has been less explored.
Damon L. Schmalzriedt +6 more
doaj +2 more sources