Results 1 to 10 of about 63,576 (258)

Regulation of the Germinal Center Response [PDF]

Frontiers in Immunology, 2018
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection.
Marisa Stebegg, Saumya D. Kumar, Saumya D. Kumar, Alyssa Silva-Cayetano, Valter R. Fonseca, Valter R. Fonseca, Michelle A. Linterman, Luis Graca, Luis Graca   +8 more
doaj   +3 more sources

Cytokines in the Germinal Center Niche [PDF]

Antibodies, 2016
Cytokines are small, secreted, glycoproteins that specifically affect the interactions and communications between cells. Cytokines are produced transiently and locally, acting in a paracrine or autocrine manner, and they are extremely potent, ligating ...
Christoph Jandl, Cecile King
doaj   +4 more sources

Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B-cell lymphoma

Haematologica, 2021
Enhancers are regulatory regions of DNA, which play a key role in cell-type specific differentiation and development. Most active enhancers are transcribed into enhancer RNA (eRNA) that can regulate transcription of target genes by means of in cis as ...
Sara Napoli, Luciano Cascione, Andrea Rinaldi, Filippo Spriano, Francesca Guidetti, Fangwen Zhang, Maria Teresa Cacciapuoti, Afua Adjeiwaa Mensah, Giulio Sartori, Nicolas Munz, Mattia Forcato, Silvio Bicciato, Annalisa Chiappella, Paola Ghione, Olivier Elemento, Leandro Cerchietti, Giorgio Inghirami, Francesco Bertoni   +17 more
doaj   +1 more source

B cell-intrinsic IRF-1 and conserved gammaherpesvirus protein kinase cooperate to promote murine gammaherpesvirus-driven germinal center response and splenic latent reservoir

Journal of Virology
Gammaherpesviruses infect >90% of adults and are associated with B cell lymphomas. These viruses drive the expansion and differentiation of germinal center B cells to amplify latent viral reservoir and ensure life-long infection of memory B cells ...
Cade R. Rahlf, Christopher N. Jondle, Erika R. Johansen, Vera L. Tarakanova   +3 more
doaj   +1 more source

B and T Cell Interplay, Germinal Center Dynamics and Role of Regulatory T Cells (Tregs) in B Cell Modulation and Immune Tolerance: A Narrative Review

Immuno
T cells and B cells are central components of the adaptive immune system, orchestrating immune responses through a complex network of interactions.
Mohammad Shahid Iqbal, Ahmad F. Arbaeen, M. A. Bendary, Hasan H. Qadi, Aisha Tabassum, Othman M. Fallatah, Sami Melebari, Nadeem Ikram, Mohammed Parvez, Kamal H. Alzabeedi   +9 more
doaj   +1 more source

The germinal center antibody response in health and disease [version 1; referees: 2 approved]

F1000Research, 2016
The germinal center response is the delayed but sustained phase of the antibody response that is responsible for producing high-affinity antibodies of the IgG, IgA and/or IgE isotypes. B cells in the germinal center undergo re-iterative cycles of somatic
Anthony L. DeFranco
doaj   +1 more source

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5

Cell Reports, 2020
Summary: The germinal center (GC) response is critical for generating high-affinity humoral immunity and immunological memory, which forms the basis of successful immunization. Control of the GC response is thought to require follicular regulatory T (Tfr)
Ine Vanderleyden, Sigrid C. Fra-Bido, Silvia Innocentin, Marisa Stebegg, Hanneke Okkenhaug, Nicola Evans-Bailey, Wim Pierson, Alice E. Denton, Michelle A. Linterman   +8 more
doaj   +1 more source

A combination of proviral and antiviral roles of CD11c- and T-bet-expressing B cells defines parameters of chronic murine gammaherpesvirus infection

mBio
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection and are associated with the development of cancer and multiple sclerosis.
Erika R. Johansen, Xander G. Bradeen, Emily V. Xie, Bonnie N. Dittel, Elizabeth A. Leadbetter, Vera L. Tarakanova   +5 more
doaj   +1 more source

Enriched LPS Staining within the Germinal Center of a Lymph Node from an HIV-Infected Long-Term Nonprogressor but Not from Progressors

Journal of Immunology Research, 2020
An increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs).
Lei Huang, Jianning Deng, Ren Lang, Guoyang Liao, Wei Jiang   +4 more
doaj   +1 more source

AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. [PDF]

PLoS ONE, 2012
Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of
Hillary Selle Gramlich, Tara Reisbig, David G Schatz   +2 more
doaj   +1 more source