Results 1 to 10 of about 8,076 (157)

Discovery of a Novel Bat Gammaherpesvirus. [PDF]

MSphere, 2016
Zoonosis is the leading cause of emerging infectious diseases. In a recent article, R. S. Shabman et al. (mSphere 1[1]:e00070-15, 2016, http://dx.doi.org/10.1128/mSphere.00070-15 ) report the identification of a novel gammaherpesvirus in a cell line ...
Blossom Damania, Kurtis M Host
exaly   +4 more sources

Antiviral Activity of 20(R)-Ginsenoside Rh2 Against Murine Gammaherpesvirus

Journal of Ginseng Research, 2017
Background: Ginsenosides are the major components of Panax ginseng Meyer, an herbal medicine used for the treatment of various diseases. Different ginsenosides contribute to the biological properties of ginseng, such as antimicrobial, anticancer, and ...
Hyeyoung Min, Soowon Kang
exaly   +4 more sources

Impaired immune surveillance exposes the germinal center as a niche for gammaherpesvirus-associated B cell lymphomagenesis [PDF]

Frontiers in Immunology
BackgroundGammaherpesviruses establish lifelong latency in B cells and are linked to multiple human lymphoid malignancies, including Epstein-Barr virus (EBV)–associated lymphomas that arise at significantly increased frequency in settings of impaired ...
Natalie Martinez, Brett A. Hoffman, Vasiliki Apostolou, April Feswick, Karl J. Ensberg, Mikayla S. Manzi, Vijay K. Sirohi, Yiping Wang, Karina E. Barbazuk, Mehmet Kara, Mehmet Kara, Manu Nair, Rolf Renne, Erik K. Flemington, Genevieve M. Crane, Scott A. Tibbetts   +15 more
doaj   +2 more sources

Genetic background modifies host and viral parameters of neonatal gammaherpesvirus infection [PDF]

Journal of Virology
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection and are associated with cancer and multiple sclerosis. Primary infection during adolescence significantly increases the risk of gammaherpesvirus-driven disease in humans ...
M. A. Brown, E. R. Johansen, X. G. Bradeen, C. R. Rahlf, E. V. Xie, V. L. Tarakanova   +5 more
doaj   +2 more sources

A combination of proviral and antiviral roles of CD11c- and T-bet-expressing B cells defines parameters of chronic murine gammaherpesvirus infection [PDF]

mBio
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection and are associated with the development of cancer and multiple sclerosis.
Erika R. Johansen, Xander G. Bradeen, Emily V. Xie, Bonnie N. Dittel, Elizabeth A. Leadbetter, Vera L. Tarakanova   +5 more
doaj   +2 more sources

Conserved gammaherpesvirus protein kinase counters myeloid cell-specific type I IFN receptor but not IRF-3 expression to promote the establishment of chronic latent infection in the spleen [PDF]

Journal of Virology
Gammaherpesviruses are prevalent pathogens that are associated with cancers and autoimmune diseases. All gammaherpesviruses encode a conserved protein kinase. Expression of orf36, the protein kinase encoded by murine gammaherpesvirus 68 (MHV68), supports
Erika R. Johansen, Matthew A. Brown, Xander G. Bradeen, Cade R. Rahlf, Daniela Avila, Damon. L. Schmalzriedt, Vera L. Tarakanova   +6 more
doaj   +2 more sources

B cell-intrinsic IRF-1 and conserved gammaherpesvirus protein kinase cooperate to promote murine gammaherpesvirus-driven germinal center response and splenic latent reservoir [PDF]

Journal of Virology
Gammaherpesviruses infect >90% of adults and are associated with B cell lymphomas. These viruses drive the expansion and differentiation of germinal center B cells to amplify latent viral reservoir and ensure life-long infection of memory B cells ...
Cade R. Rahlf, Christopher N. Jondle, Erika R. Johansen, Vera L. Tarakanova   +3 more
doaj   +2 more sources

B cell-intrinsic interleukin 17 receptor A signaling supports the establishment of chronic murine gammaherpesvirus 68 infection [PDF]

Journal of Virology
The human-specific gammaherpesviruses Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus infect >95% of all adults, establish lifelong infections, and are associated with multiple different cancers, including B-cell lymphomas.
Sheikh Tahir Majeed, Nicholas P. Huss, Samantha M. Bradford, Christopher N. Jondle   +3 more
doaj   +2 more sources

Genome-Wide Transcript Structure Resolution Reveals Abundant Alternate Isoform Usage From Murine Gammaherpesvirus 68

Cell Reports, 2019
Summary: The gammaherpesviruses, including Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 (MHV68, MuHV-4, γHV68), are etiologic agents of a wide range of lymphomas and non-hematological ...
Scott A Tibbetts, Tina O'Grady, Yiping Wang   +2 more
exaly   +3 more sources

Targeting Host Metabolic and Epigenetic Rewiring Blocks Lytic Gammaherpesvirus Production [PDF]

Viruses
Gammaherpesviruses are oncogenic viruses that reprogram host cell metabolism to support viral production. Among these, murine herpesvirus 68 (MHV-68) serves as a model system for studying lytic gammaherpesvirus infection and associated host cell changes.
Morgan C. Jones, Tina M. Le, Connor J. Mahoney, Sara K. Hartman, Robynne D. Dona, Yennifer A. Gaspar, Sennah J. Hong, Benjamin R. Sheirbon, Thelma M. Escobar, Tracie Delgado   +9 more
doaj   +2 more sources