Results 1 to 10 of about 1,678 (160)

The MHV68 M2 Protein Drives IL-10 Dependent B Cell Proliferation and Differentiation [PDF]

PLoS Pathogens, 2008
Murine gammaherpesvirus 68 (MHV68) establishes long-term latency in memory B cells similar to the human gammaherpesvirus Epstein Barr Virus (EBV). EBV encodes an interleukin-10 (IL-10) homolog and modulates cellular IL-10 expression; however, the role of
Samuel H Speck
exaly   +3 more sources

Development of KSHV Vaccine Platforms and Chimeric MHV68-K-K8.1 Glycoprotein for Evaluating the in Vivo Immunogenicity and Efficacy of KSHV Vaccine Candidates. [PDF]

MBio
Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 is an etiological agent of Kaposi’s Sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. Considering the high seroprevalence reaching up to 80% in sub-Saharan Africa,
Pei-Ching Chang, Jae U. Jung, Dokyun Kim
exaly   +4 more sources

A Bivalent mRNA Vaccine Efficiently Prevents Gammaherpesvirus Latent Infection [PDF]

Vaccines
Background: It is still challenging to develop effective vaccines against tumorigenic human gammaherpesviruses such as Epstein–Barr virus (EBV). A major obstacle is the lack of a small animal model that reproduces the natural infection course of human ...
Zhong Huang, Xiaozhen Liang, Haikun Wang
exaly   +4 more sources

Conditional Mutagenesis in Vivo Reveals Cell Type- and Infection Stage-Specific Requirements for LANA in Chronic MHV68 Infection [PDF]

PLoS Pathogens, 2018
Gammaherpesvirus (GHV) pathogenesis is a complex process that involves productive viral replication, dissemination to tissues that harbor lifelong latent infection, and reactivation from latency back into a productive replication cycle.
Douglas W White, Arundhati Gupta, Craig Forrest   +2 more
exaly   +3 more sources

A Role of Hypoxia-Inducible Factor 1 Alpha in Murine Gammaherpesvirus 68 (MHV68) Lytic Replication and Reactivation From Latency [PDF]

PLoS Pathogens, 2019
The hypoxia-inducible factor 1 alpha (HIF1α) protein and the hypoxic microenvironment are critical for infection and pathogenesis by the oncogenic gammaherpesviruses (γHV), Kaposi sarcoma herpes virus (KSHV) and Epstein-Barr virus (EBV).
Darlah M López-Rodríguez, Varvara Kirillov, Laurie T. Krug   +2 more
exaly   +4 more sources

Optimized Detection of Acute MHV68 Infection With a Reporter System Identifies Large Peritoneal Macrophages as a Dominant Target of Primary Infection

Frontiers in Microbiology, 2021
Investigating the dynamics of virus-host interactions in vivo remains an important challenge, often limited by the ability to directly identify virally infected cells.
Leslie J. Berg, Eva M Medina, Eric T Clambey   +2 more
exaly   +3 more sources

The Infection of Murine Gammaherpesvirus-68 Delays the Early Embryonic Development of Zebrafish

Reproduction and Breeding, 2023
Zebrafish is a model animal for aquaculture as well as bio-medicine. Murine gamma-herpesvirus 68 (MHV68) is widely regarded as a model for the study of human gamma herpesviruses such as Kaposi's sarcoma-associated herpesvirus (KSHV).
Mengdie Chi
exaly   +3 more sources

Repression of productive viral replication by KSHV LANA correlates with reduced adaptive immune activation: potential implications for KSHV immune evasion [PDF]

mBio
Adaptive immune responses to primary Kaposi sarcoma-associated herpesvirus (KSHV) infection are poorly defined. To develop better small-animal models for understanding KSHV pathogenesis and immunity, we previously generated a chimeric virus in which the ...
Steven J. Murdock, Shana M. Owens, Darby G. Oldenburg, J. Craig Forrest   +3 more
doaj   +2 more sources

Genetic background modifies host and viral parameters of neonatal gammaherpesvirus infection [PDF]

Journal of Virology
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection and are associated with cancer and multiple sclerosis. Primary infection during adolescence significantly increases the risk of gammaherpesvirus-driven disease in humans ...
M. A. Brown, E. R. Johansen, X. G. Bradeen, C. R. Rahlf, E. V. Xie, V. L. Tarakanova   +5 more
doaj   +2 more sources

Eph receptor tyrosine kinases are functional entry receptors for murine gammaherpesvirus 68. [PDF]

PLoS Pathogens
Interactions between viral glycoproteins and cellular receptors determine virus tropism and represent promising targets for vaccines. Eph receptor tyrosine kinases are conserved receptors for the human oncogenic gammaherpesviruses, Kaposi sarcoma ...
Anna K Großkopf, Victor Tobiasson, Laurie T Krug   +2 more
doaj   +2 more sources