Results 1 to 10 of about 1,199 (116)

Development of KSHV vaccine platforms and chimeric MHV68-K-K8.1 glycoprotein for evaluating the in vivo immunogenicity and efficacy of KSHV vaccine candidates [PDF]

MBio
Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 is an etiological agent of Kaposi’s Sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. Considering the high seroprevalence reaching up to 80% in sub-Saharan Africa,
Dokyun Kim, Chih-Jen Lai, Inho Cha
exaly   +4 more sources

Optimized Detection of Acute MHV68 Infection With a Reporter System Identifies Large Peritoneal Macrophages as a Dominant Target of Primary Infection

Frontiers in Microbiology, 2021
Investigating the dynamics of virus-host interactions in vivo remains an important challenge, often limited by the ability to directly identify virally infected cells.
Eric T Clambey, Linda F van Dyk, Leslie J Berg   +2 more
exaly   +3 more sources

Cross-Species Insights Into Gamma Herpesvirus Transcriptomes: Long-Read and Multi-Omics Perspectives. [PDF]

J Med Virol
ABSTRACT Comparative transcriptome analyses of gamma herpesviruses have been revolutionized by long‐read sequencing and integrative multi‐omics approaches, enabling unprecedented resolution of viral gene expression. Cross‐species studies of Kaposi's sarcoma‐associated herpesvirus (KSHV), Epstein–Barr virus (EBV), and murine gamma herpesvirus 68 (MHV68)
Shekhar R, McMahon S, Tibbetts SA, Flemington EK, Renne R.   +4 more
europepmc   +2 more sources

Eph receptor tyrosine kinases are functional entry receptors for murine gammaherpesvirus 68. [PDF]

PLoS Pathogens
Interactions between viral glycoproteins and cellular receptors determine virus tropism and represent promising targets for vaccines. Eph receptor tyrosine kinases are conserved receptors for the human oncogenic gammaherpesviruses, Kaposi sarcoma ...
Anna K Großkopf, Victor Tobiasson, Laurie T Krug   +2 more
doaj   +2 more sources

Model Systems of Gammaherpesvirus Infection, Immunity, and Disease. [PDF]

J Med Virol
ABSTRACT Epstein‐Barr virus (EBV) and Kaposi's sarcoma‐associated herpesvirus (KSHV) are oncogenic human gammaherpesviruses (GHVs) associated with a broad spectrum of malignancies and chronic diseases. However, direct studies of these viruses in humans are limited by ethical constraints, technical challenges, and their strict species specificity.
Gupta A, Li R, Shair K, Gao SJ.
europepmc   +2 more sources

The MHV68 M2 Protein Drives IL-10 Dependent B Cell Proliferation and Differentiation [PDF]

PLoS Pathogens, 2008
Murine gammaherpesvirus 68 (MHV68) establishes long-term latency in memory B cells similar to the human gammaherpesvirus Epstein Barr Virus (EBV). EBV encodes an interleukin-10 (IL-10) homolog and modulates cellular IL-10 expression; however, the role of
Samuel H Speck
exaly   +2 more sources

The infection of murine gammaherpesvirus-68 delays the early embryonic development of zebrafish

Reproduction and Breeding, 2023
Zebrafish is a model animal for aquaculture as well as bio-medicine. Murine gamma-herpesvirus 68 (MHV68) is widely regarded as a model for the study of human gamma herpesviruses such as Kaposi's sarcoma-associated herpesvirus (KSHV).
Jun Yan, Mengdie Chi, Jun Xiao, Meiling Liu, Hao Feng   +4 more
exaly   +3 more sources

Preexisting helminth challenge exacerbates infection and reactivation of gammaherpesvirus in tissue resident macrophages. [PDF]

PLoS Pathogens, 2023
Even though gammaherpesvirus and parasitic infections are endemic in parts of the world, there is a lack of understanding about the outcome of coinfection. In humans, coinfections usually occur sequentially, with fluctuating order and timing in different
Christina M Zarek, Chaitanya Dende, Jaime Coronado, Mihir Pendse, Phillip Dryden, Lora V Hooper, Tiffany A Reese   +6 more
doaj   +2 more sources

A Bivalent mRNA Vaccine Efficiently Prevents Gammaherpesvirus Latent Infection [PDF]

Vaccines
Background: It is still challenging to develop effective vaccines against tumorigenic human gammaherpesviruses such as Epstein–Barr virus (EBV). A major obstacle is the lack of a small animal model that reproduces the natural infection course of human ...
Yannan Yin, Jinkai Zang, Huichun Shi, Zhuang Wang, Linlin Kuang, Shuxia Wang, Haikun Wang, Ning Li, Xiaozhen Liang, Zhong Huang   +9 more
doaj   +2 more sources

Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease [PDF]

Journal of Neuroinflammation
Background Growing evidence indicates that Epstein-Barr virus (EBV), a gammaherpesvirus, plays a central role in the pathogenesis of multiple sclerosis (MS).
Alexander Muselman, Sameera Kongara, Nathan Hsu, Asha Aggarwal, Joanna Yu, Jayakumar Rajadas, Edgar G. Engleman   +6 more
doaj   +2 more sources