Results 41 to 50 of about 1,517 (162)

Virus-Encoded MicroRNAs Facilitate Gammaherpesvirus Latency and Pathogenesis In Vivo

mBio, 2014
Gammaherpesviruses, including Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV, or HHV-8), and murine gammaherpesvirus 68 (MHV68, γHV68, or MuHV-4), are B cell-tropic pathogens that each encode at least 12 microRNAs (miRNAs).
Emily R. Feldman, Mehmet Kara, Carrie B. Coleman, Katrina R. Grau, Lauren M. Oko, Brian J. Krueger, Rolf Renne, Linda F. van Dyk, Scott A. Tibbetts   +8 more
doaj   +1 more source

Gammaherpesvirus-driven plasma cell differentiation regulates virus reactivation from latently infected B lymphocytes. [PDF]

PLoS Pathogens, 2009
Gammaherpesviruses chronically infect their host and are tightly associated with the development of lymphoproliferative diseases and lymphomas, as well as several other types of cancer.
Xiaozhen Liang, Christopher M Collins, Justin B Mendel, Neal N Iwakoshi, Samuel H Speck   +4 more
doaj   +1 more source

Viral pseudoenzymes in infection and immunity

The FEBS Journal, Volume 287, Issue 19, Page 4300-4309, October 2020., 2020
Viral pseudoenzymes are represented by enzyme‐deficient homologs of glutamine amidotransferase (GAT), kinase, and superoxide dismutase that modulate the signaling output in immune defense, viral genome replication, and cell proliferation, respectively.
Ting‐Yu Wang, Jun Zhao, Ali Can Savas, Shu Zhang, Pinghui Feng   +4 more
wiley   +1 more source

A tissue culture model of murine gammaherpesvirus replication reveals roles for the viral cyclin in both virus replication and egress from infected cells.

PLoS ONE, 2014
Passage through the eukaryotic cell cycle is regulated by the activity of cyclins and their cyclin-dependent kinase partners. Rhadinoviruses, such as Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68), encode a viral ...
Francine M Scott, Samuel H Speck
doaj   +1 more source

RIP1 kinase activity is critical for skin inflammation but not for viral propagation

Journal of Leukocyte Biology, Volume 107, Issue 6, Page 941-952, June 2020., 2020
Inhibiting RIP1 has benefits to skin inflammation but not certain viral infections. Abstract Receptor interacting protein kinase 1 (RIP1) is a critical effector of inflammatory responses and cell death activation. Cell death pathways regulated by RIP1 include caspase‐dependent apoptosis and caspase‐independent necroptosis.
Joshua D. Webster, Youngsu C. Kwon, Summer Park, Hua Zhang, Nick Corr, Nina Ljumanovic, Adeyemi O. Adedeji, Eugene Varfolomeev, Tatiana Goncharov, Jessica Preston, Sara F. Santagostino, Snahel Patel, Min Xu, Jonathan Maher, Brent S. McKenzie, Domagoj Vucic   +15 more
wiley   +1 more source

Regulation of cGAS‐Mediated Immune Responses and Immunotherapy

Advanced Science, Volume 7, Issue 6, March 18, 2020., 2020
The cGAS‐STING pathway is central to innate immunity and must be tightly regulated. cGAS performs essential roles in numerous immune functions such as DNA sensing, antiviral defense, antitumor immunity, senescence, and DNA repair. Aberrant cGAS activation leads to autoimmune and inflammatory diseases.
Abdullah F. U. H. Saeed, Xinglin Ruan, Hongxin Guan, Jingqian Su, Songying Ouyang   +4 more
wiley   +1 more source

Multiple Roles of 25‐Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the last decades.
Qin Cao, Zhongzhong Liu, Yan Xiong, Zibiao Zhong, Qifa Ye, Ilaria Peluso   +5 more
wiley   +1 more source

IL-4c-induced LPM expansion is sufficient to increase viral infection in the peritoneal cavity during acute MHV68 infection.

, 2023
(A) Timeline of intraperitoneal IL-4 complex (IL-4c), thioglycolate (Thio) treatments and MHV68.ORF73β-lactamase intraperitoneal infection (106 plaque forming units (PFU)). 5μg of IL-4 and 25 μg α-IL-4 were complexed and injected for LPM expansion.
Mihir Pendse (17181225), Phillip Dryden (17181228), Jaime Coronado (16770120), Lora V. Hooper (9645168), Chaitanya Dende (186970), Tiffany A. Reese (17181231), Christina M. Zarek (17181222)   +6 more
core   +1 more source

Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity. [PDF]

PLoS Pathogens, 2015
Immunity to non-cerebral severe malaria is estimated to occur within 1-2 infections in areas of endemic transmission for Plasmodium falciparum. Yet, nearly 20% of infected children die annually as a result of severe malaria.
Caline G Matar, Neil R Anthony, Brigid M O'Flaherty, Nathan T Jacobs, Lalita Priyamvada, Christian R Engwerda, Samuel H Speck, Tracey J Lamb   +7 more
doaj   +1 more source

Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis. [PDF]

PLoS ONE, 2009
Several studies have implicated viral infection as an important factor in the pathogenesis of IPF and related fibrotic lung disorders. Viruses are thought to cause epithelial cell injury and promote epithelial-mesenchymal transition (EMT), a process ...
Veronika Pozharskaya, Edilson Torres-González, Mauricio Rojas, Anthony Gal, Minal Amin, Sheila Dollard, Jesse Roman, Arlene A Stecenko, Ana L Mora   +8 more
doaj   +1 more source