Co‐ and polymicrobial infections in the gut mucosa: The host–microbiota–pathogen perspective
Cellular Microbiology, Volume 23, Issue 2, February 2021., 2021 Abstract Infections in humans occur in the context of complex niches where the pathogen interacts with both the host microenvironment and immune response, and the symbiotic microbial community. The polymicrobial nature of many human infections adds a further layer of complexity.
Teresa Frisan
wiley +1 more source
Tracking murine gammaherpesvirus 68 infection of germinal center B cells in vivo.
PLoS ONE, 2012 Infection of mice with murine gammaherpesvirus 68 (MHV68) provides a tractable small animal model to study various aspects of persistent gammaherpesvirus infection. We have previously utilized a transgenic MHV68 that expresses enhanced yellow fluorescent
Christopher M Collins, Samuel H Speck
doaj +1 more source
Animal models of human herpesvirus infection. [PDF]
Animal Model Exp MedHuman herpesvirus can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing.
Jia Z, Zhang D, Zhu L, Xue J.
europepmc +2 more sources
Tick-Borne Transmission of Murine Gammaherpesvirus 68
Frontiers in Cellular and Infection Microbiology, 2017 Herpesviruses are a large group of DNA viruses infecting mainly vertebrates. Murine gammaherpesvirus 68 (MHV68) is often used as a model in studies of the pathogenesis of clinically important human gammaherpesviruses such as Epstein-Barr virus and Kaposi'
Valeria Hajnická +12 more
doaj +1 more source
Interleukin 21 signaling in B cells is required for efficient establishment of murine gammaherpesvirus latency. [PDF]
PLoS Pathogens, 2015 The human gammaherpesviruses take advantage of normal B cell differentiation pathways to establish life-long infection in memory B cells. Murine gammaherpesvirus 68 (MHV68) infection of laboratory strains of mice also leads to life-long infection in ...
Christopher M Collins, Samuel H Speck
doaj +1 more source
Gating strategy for MHV68+ PECs during latency.
, 2023 CD11b+ cells were isolated by microbeads before flow to enrich for MHV68+ cells. (TIF)
Mihir Pendse (17181225) +6 more
core +1 more source
Virus-Encoded MicroRNAs Facilitate Gammaherpesvirus Latency and Pathogenesis
mBio, 2014 Gammaherpesviruses, including Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV, or HHV-8), and murine gammaherpesvirus 68 (MHV68, γHV68, or MuHV-4), are B cell-tropic pathogens that each encode at least 12 microRNAs (miRNAs).
Emily R. Feldman +8 more
doaj +1 more source
Preformed LDAs and impact of MHV68 on chronic HP infection.
, 2023 (A-D) HP-infected or uninfected mice were challenged with 106 PFU of MHV68 i.p. PECs and/or splenocytes were isolated at day 28–31 of MHV68 infection. (A) C57BL/6 PECs were collected at day 28–31 of MHV68 infection for LDAs.
Mihir Pendse (17181225) +6 more
core +1 more source
Gating strategy for MHV68+ PECs during acute replication.
, 2023 Gating strategy for MHV68+ PECs during acute replication.
Mihir Pendse (17181225) +6 more
core +1 more source
Murine gammaherpesvirus M2 antigen modulates splenic B cell activation and terminal differentiation in vivo. [PDF]
PLoS Pathogens, 2017 Murine gammaherpesvirus 68 (MHV68) infection of laboratory strains of mice has provided a tractable small animal model for dissecting gammaherpesvirus pathogenesis.
Shariya Terrell, Samuel H Speck
doaj +1 more source