Results 61 to 70 of about 1,517 (162)

Targeted Protein Degradation of the Latency‐Associated Nuclear Antigen Evicts Kaposi Sarcoma‐Associated Herpesvirus Episomes From Infected Cells In Vitro

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT Kaposi sarcoma‐associated herpesvirus (KSHV), a gamma‐herpesvirus, is the main etiological agent of several tumors, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). The large, double‐stranded viral genome of KSHV is maintained as a latent episome in the nucleus of host cells, where a small subset of viral genes is expressed
Sarah McMahon, Maha Amer, Brooke Hall, Ritu Shekhar, Rolf Renne   +4 more
wiley   +1 more source

2020 Annual World Congress of the Pulmonary Vascular Research Institute

, 2021
Pulmonary Circulation, Volume 11, Issue 2, Page 1-75, April-June 2021.
wiley   +1 more source

Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery.

PLoS Pathogens, 2019
Gammaherpesviruses, including the human pathogens Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish lifelong latent infection in B cells and are associated with a variety of tumors. In addition to protein coding genes,
Whitney L Bullard, Mehmet Kara, Lauren A Gay, Sunantha Sethuraman, Yiping Wang, Shreya Nirmalan, Alim Esemenli, April Feswick, Brett A Hoffman, Rolf Renne, Scott A Tibbetts   +10 more
doaj   +1 more source

T Cell-Specific STAT1 Expression Promotes Lytic Replication and Supports the Establishment of Gammaherpesvirus Latent Reservoir in Splenic B Cells

mBio, 2022
Gammaherpesviruses establish lifelong infections in most vertebrate species, including humans and rodents, and are associated with cancers, including B cell lymphomas.
P. A. Sylvester, C. N. Jondle, D. L. Schmalzriedt, B. N. Dittel, V. L. Tarakanova   +4 more
doaj   +1 more source

Role of Viral miRNAs and Epigenetic Modifications in Epstein‐Barr Virus‐Associated Gastric Carcinogenesis

Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016
MicroRNAs are short (21–23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs. Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms.
Aldo Giudice, Giovanni D’Arena, Anna Crispo, Mario Felice Tecce, Flavia Nocerino, Maria Grimaldi, Emanuela Rotondo, Anna Maria D’Ursi, Mario Scrima, Massimiliano Galdiero, Gennaro Ciliberto, Mario Capunzo, Gianluigi Franci, Antonio Barbieri, Sabrina Bimonte, Maurizio Montella, Denis Delic   +16 more
wiley   +1 more source

Global mRNA degradation during lytic gammaherpesvirus infection contributes to establishment of viral latency. [PDF]

PLoS Pathogens, 2011
During a lytic gammaherpesvirus infection, host gene expression is severely restricted by the global degradation and altered 3' end processing of mRNA. This host shutoff phenotype is orchestrated by the viral SOX protein, yet its functional significance ...
Justin M Richner, Karen Clyde, Andrea C Pezda, Benson Yee Hin Cheng, Tina Wang, G Renuka Kumar, Sergio Covarrubias, Laurent Coscoy, Britt Glaunsinger   +8 more
doaj   +1 more source

The innate and T-cell mediated immune response during acute and chronic gammaherpesvirus infection

Frontiers in Cellular and Infection Microbiology, 2023
Immediately after entry into host cells, viruses are sensed by the innate immune system, leading to the activation of innate antiviral effector mechanisms including the type I interferon (IFN) response and natural killer (NK) cells.
Viktoria Rex, Razieh Zargari, Markus Stempel, Markus Stempel, Stephan Halle, Stephan Halle, Melanie M. Brinkmann, Melanie M. Brinkmann   +7 more
doaj   +1 more source

Insight into structural properties of viral G protein‐coupled receptors and their role in the viral infection: IUPHAR Review 41

British Journal of Pharmacology, Volume 182, Issue 1, Page 26-51, January 2025.
G protein‐coupled receptors (GPCRs) are pivotal in cellular signalling and drug targeting. Herpesviruses encode GPCRs (vGPCRs) to manipulate cellular signalling, thereby regulating various aspects of the virus life cycle, such as viral spreading and immune evasion.
Naotaka Tsutsumi, Dagmar Fæster Kildedal, Olivia Kramer Hansen, Qianqian Kong, Dominique Schols, Tom Van Loy, Mette Marie Rosenkilde   +6 more
wiley   +1 more source

Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity

iScience, 2018
Summary: To gain insights into the molecular mechanisms and pathways involved in the activation of γ-herpesvirus (MHV68)-specific T cell receptor transnuclear (TN) CD8+ T cells, we performed a comprehensive transcriptomic analysis.
Manpreet Kaur, Dhaneshwar Kumar, Vincent Butty, Sudhakar Singh, Alexandre Esteban, Gerald R. Fink, Hidde L. Ploegh, Sharvan Sehrawat   +7 more
doaj   +1 more source

Recurrent encephalitis and stroke following cessation of acyclovir prophylaxis in a patient with neonatal herpes simplex virus with RNF213 mutation

Annals of the Child Neurology Society, Volume 2, Issue 3, Page 235-241, September 2024.
Abstract Objective Herpes simplex virus (HSV) encephalitis can be associated with many secondary neurological complications, but having multiple episodes of recurrent neurological complications is rare in an individual. Understanding the course of each complication can reduce time to diagnosis and adequate treatment. Additionally, we postulate the role
Rutu M. Dave, Janetta Arellano, Charles Grose, Rachel Pearson   +3 more
wiley   +1 more source