Results 61 to 70 of about 1,598 (170)
Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity. [PDF]
PLoS Pathogens, 2015 Immunity to non-cerebral severe malaria is estimated to occur within 1-2 infections in areas of endemic transmission for Plasmodium falciparum. Yet, nearly 20% of infected children die annually as a result of severe malaria.
Caline G Matar +7 more
doaj +1 more source
PLoS ONE, 2021 Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV) are cancer-causing viruses that establish lifelong infections in humans. Gene editing using the Cas9-guideRNA (gRNA) CRISPR system has been applied to decrease the latent load of EBV in human
Hui-Chen Chang Foreman +7 more
doaj +1 more source
, 2013 A) An expression cassette that expresses a histone H2bYFP fusion protein was cloned into the intergenic region between ORFs 27 and 29b. The cassette was flanked by chromatin insulators (XL9CD) as previously described [4] B). Representative plaques formed
Samuel H. Speck (70359) +1 more
core +1 more source
Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection. [PDF]
PLoS ONE, 2012 Herpesviruses are characterized by their ability to establish lifelong latent infection. The gammaherpesvirus subfamily is distinguished by lymphotropism, establishing and maintaining latent infection predominantly in B lymphocytes.
Kathleen S Gray +2 more
doaj +1 more source
Phosphoproteomic analyses reveal signaling pathways that facilitate lytic gammaherpesvirus replication. [PDF]
PLoS Pathogens, 2013 Lytic gammaherpesvirus (GHV) replication facilitates the establishment of lifelong latent infection, which places the infected host at risk for numerous cancers. As obligate intracellular parasites, GHVs must control and usurp cellular signaling pathways
James A Stahl +6 more
doaj +1 more source
Abbreviated skin allograft survival in MHV68 is not due to MHV68-associated Vβ4+CD8+ expansion.
, 2013 A) Representative flow cytometric plots showing TCR Vβ4 staining versus CD8 staining in mice infected with wild-type MHV68 (left) and the mutant M1.STOP MHV68 (right).
Danxia Duan (441626) +11 more
core +1 more source
mSphere, 2023 Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair.
Kyle R. Smith +7 more
doaj +1 more source
, 2013 Mice were infected with a 100 pfu of either MHV68-YFP or M2.Stop-YFP viruses via intranasal inoculation. (A) The absence of MHV68 infected plasma cells in mice infected with the M2.Stop-YFP virus.
Neal N. Iwakoshi (369025) +4 more
core +1 more source
Advanced Science, Volume 13, Issue 31, 4 June 2026.RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li +5 more
wiley +1 more source
A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality. [PDF]
PLoS Pathogens, 2011 The gammaherpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish latency in memory B lymphocytes and promote lymphoproliferative disease in immunocompromised individuals.
Pratyusha Mandal +6 more
doaj +1 more source