Results 81 to 90 of about 1,517 (162)
, 2019 A. The top 15 canonical pathways enriched for targets of MHV68 miRNAs in either fibroblasts (left panel) or B cells (right panel). Bar graphs correspond with the top X-axes, and depict the percent of target transcripts that overlap (blue) with each ...
Yiping Wang (1484218) +10 more
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IRF4 is required for establishment of MHV68 latency as well as for reactivation from latency.
, 2014 IRF4fl/fl mice were infected with 1000 PFU of either MHV68-Cre or MHV68-WT virus intranasally. On day 16 post infection, splenocytes were analyzed by limiting dilution analyses to determine (A) the frequency of virus capable of establishing latency and ...
Samuel H. Speck (70359) +1 more
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, 2014 C57Bl/6 mice were infected via intranasal inoculation with 1,000 pfu of either WT MHV68, vCyclin.stop or a recombinant MHV68 expressing the KSHV v-cyclin from the MHV68 v-cyclin locus (K-cyclin).
Francine M. Scott (546179) +1 more
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Cell Reports, 2019 Summary: The gammaherpesviruses, including Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), and murine gammaherpesvirus 68 (MHV68, MuHV-4, γHV68), are etiologic agents of a wide range of lymphomas and non-hematological ...
Tina O’Grady +8 more
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MHV68 miRNA targets extensively overlap with EBV and KSHV miRNA targets.
, 2019 A. Diagram indicates the number of unique host mRNA targets of MHV68 miRNAs identified in one, two or three biological replicates (out of three). B. Venn diagram indicates the number of host mRNA targets of MHV68 miRNAs (identified in at least two of ...
Yiping Wang (1484218) +10 more
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The NC-specific B cell response in DR1 mice is modulated by concurrent infection with MHV68.
, 2012 (A–D) Virus-specific ASC frequencies. DR1 and B10 mice were infected intranasally with NC only, or with NC and MHV68. ASC frequencies in the MedLN were determined by ELISPOT assay on day 8 (A and B) and day 10 (C and D) after infection. ASCs specific for
Aarthi Sundararajan (175739) +10 more
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MHV68 D-type cyclin ortholog enhances CDK-related phosphorylation in infected cells.
, 2013 (A) 3T3 fibroblasts were mock infected or infected with WT or transposon mutant (tn) MHV68 viruses at MOI = 5 PFU/cell. (B) Cells were mock infected or infected with v-cyclin-null (ORF72-null) or genetically repaired WT control (ORF72-MR) MHV68 ...
Daniel E. Voth (196250) +6 more
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PLoS Pathogens, 2014 MHV68 is a murine gammaherpesvirus that infects laboratory mice and thus provides a tractable small animal model for characterizing critical aspects of gammaherpesvirus pathogenesis.
Brigid M O'Flaherty +3 more
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Plasma cells contribute significantly to spontaneous MHV68 reactivation following explant.
, 2013 (A and B) Purification of plasma cells and non-plasma cells by flow cytometry. Shown are representative flow plots unsorted (A) and post-sorting (B), as well as the gates used to isolate the plasma cells and non-plasma cell populations. Cells were sorted
Neal N. Iwakoshi (369025) +4 more
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PLoS Pathogens, 2014 Reactivation of the gammaherpesviruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus 68 (MHV68) from latently infected B cells has been linked to plasma cell differentiation. We have previously shown
Udaya S Rangaswamy, Samuel H Speck
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