Results 81 to 90 of about 1,598 (170)
mSphere, 2016 Recent intense investigations have uncovered important functions for a diverse array of novel noncoding RNA (ncRNA) species, including microRNAs (miRNAs) and long noncoding RNAs.
Emily R. Feldman +9 more
doaj +1 more source
Annals of the Child Neurology Society, Volume 2, Issue 3, Page 235-241, September 2024.Abstract Objective Herpes simplex virus (HSV) encephalitis can be associated with many secondary neurological complications, but having multiple episodes of recurrent neurological complications is rare in an individual. Understanding the course of each complication can reduce time to diagnosis and adequate treatment. Additionally, we postulate the role
Rutu M. Dave +3 more
wiley +1 more source
Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity
iScience, 2018 Summary: To gain insights into the molecular mechanisms and pathways involved in the activation of γ-herpesvirus (MHV68)-specific T cell receptor transnuclear (TN) CD8+ T cells, we performed a comprehensive transcriptomic analysis.
Manpreet Kaur +7 more
doaj +1 more source
Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. [PDF]
PLoS ONE, 2013 The mechanisms underlying latent-virus-mediated heterologous immunity, and subsequent transplant rejection, especially in the setting of T cell costimulation blockade, remain undetermined. To address this, we have utilized MHV68 to develop a rodent model
Jonathan M Beus +11 more
doaj +1 more source
MHV68 infection upregulates expression of HIF1 alpha.
, 2019 (A) 3T12 fibroblasts were infected with a wild type strain of MHV68 (WUMS) (5 MOI) at 21% O2 (cell culture incubator) and protein lysates were analyzed by western blot for the expression of HIF1α protein at different time-points.
Darlah M. López-Rodríguez (8098544) +4 more
core +1 more source
cGAS–STING, an important signaling pathway in diseases and their therapy
MedComm, Volume 5, Issue 4, April 2024.cGAS–STING signaling pathway was discovered in 2013. With so many years of in‐depth research on cGAS–STING, people have realized that cGAS–STING plays a key role in human diseases, particularly DNA‐triggered inflammatory diseases and cancers. This review summarize the ancient origin, triggers, transduction, and regulating mechanisms of the cGAS–STING ...
Qijie Li +5 more
wiley +1 more source
PLoS Pathogens, 2017 Many pathogens, including Kaposi's sarcoma herpesvirus (KSHV), lack tractable small animal models. KSHV persists as a multi-copy, nuclear episome in latently infected cells. KSHV latency-associated nuclear antigen (kLANA) binds viral terminal repeat (kTR)
Aline C Habison +10 more
doaj +1 more source
MHV68 infection induces SINE RNA expression with rapid kinetics.
, 2015 (A) NIH3T3 cells were infected with MHV68 at an MOI of 5, and 24 hpi total RNA was primer extended for B1, B2, and 7SK RNAs. (B) The RNA described in (A) was used to monitor the levels of tRNAVal, tRNALeu, 5S rRNA, and 7SL RNA by small RNA northern ...
Emma Abernathy (392118) +2 more
core +1 more source
Crystal structure of the tegument protein UL82 (pp71) from human cytomegalovirus
Protein Science, Volume 33, Issue 3, March 2024.Abstract Human cytomegalovirus (HCMV) is an opportunistic pathogen that infects a majority of the world population. It may cause severe disease in immunocompromised people and lead to pregnancy loss or grave disabilities of the fetus upon congenital infection.
Jan Eberhage +9 more
wiley +1 more source
MHV68 causes systemic elevation of the chemoattractant chemokines CXCL9 and CXCL10.
, 2013 A) Quantification of CXCL9 in the plasma of MHV68-infected animals measured every 2 weeks for 10 weeks after infection. B) Quantification of CXCL10 in the plasma of MHV68-infected animals measured every 2 weeks for 10 weeks after infection.
Danxia Duan (441626) +11 more
core +1 more source