Results 101 to 110 of about 1,598 (170)
Plasma cells contribute significantly to spontaneous MHV68 reactivation following explant.
, 2013 (A and B) Purification of plasma cells and non-plasma cells by flow cytometry. Shown are representative flow plots unsorted (A) and post-sorting (B), as well as the gates used to isolate the plasma cells and non-plasma cell populations. Cells were sorted
Neal N. Iwakoshi (369025) +4 more
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PLoS Pathogens, 2014 MHV68 is a murine gammaherpesvirus that infects laboratory mice and thus provides a tractable small animal model for characterizing critical aspects of gammaherpesvirus pathogenesis.
Brigid M O'Flaherty +3 more
doaj +1 more source
Thirty novel miRNAs in the MHV68 or mouse genomes.
, 2012 aThe number of reads perfectly mapping to pre-miRNA hairpin sequences in all samples.bThe rank of miRNAs relative to all known and novel murine miRNAs.*The rank of miRNAs relative to all the MHV68 miRNAs.
Weixiong Zhang (10203) +1 more
core +1 more source
Number of host mRNA hybrid sequences containing MHV68 miRNAs.
, 2019 For each hybrid containing a host mRNA, the total number of sequences containing each of the 28 potential mature MHV68 miRNAs was enumerated. For each sample type (latency, reactivation, lytic) and corresponding miRNA, numbers represent the total unique ...
Yiping Wang (1484218) +10 more
core +1 more source
Alternative approach to deplete HIF1α impairs MHV68 replication.
, 2019 (A) 3T12 cells were treated with a pool of siHIF1α or siNT (non-targeting) for 24 hours. Top left panel: HIF1α protein expression at 24hpi of uninfected and MHV68 (MOI:3) infected cells at 3%O2. Beta-actin was probed for loading control. Top middle panel:
Darlah M. López-Rodríguez (8098544) +4 more
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PLoS ONE, 2014 The human gammaherpesviruses establish life-long infections that are associated with the development of lymphomas and neoplasms, especially in immunocompromised individuals. T cells play a crucial role in the control of gammaherpesvirus infection through
Brandon Cieniewicz +2 more
doaj +1 more source
, 2014 (A) Schematic illustration depicting the v-cyclin locus and insertion of KSHV v-cyclin in place of the MHV68 v-cyclin open reading frame. (B) RL-65 cells were plated to confluency and then infected at an MOI of 0.05 with either WT MHV68, vCyclin.stop or ...
Francine M. Scott (546179) +1 more
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, 2013 Six mLANA mutants were introduced into the MHV68 genome using BAC recombineering. (A) After infection of NIH3T3 fibroblasts with each MHV68-73TRN virus at an MOI of 3 PFU/mL, cell lysates were harvested at one and seven hours post-infection.
Samuel H. Speck (70359) +3 more
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A Role for the Hypoxia-Inducible Factor 1 Alpha in Murine Gammaherpesvirus 68 (MHV68) Lytic Replication and Reactivation from Latency [PDF]
, 2019 The hypoxia inducible factor 1 alpha (HIF1α) protein and the hypoxic microenvironment are critical for infection and pathogenesis by the oncogenic gammaherpesviruses (γHV) such as Kaposi' Sarcoma-associated Herpes Virus (KSHV) and Epstein-Barr virus (EBV)
López-Rodríguez, Darlah
core +2 more sources
Pathogens, 2017 RTA, the viral Replication and Transcription Activator, is essential for rhadinovirus lytic gene expression upon de novo infection and reactivation from latency.
Alexis L. Santana +8 more
doaj +1 more source