Results 121 to 130 of about 1,598 (170)

IL-21 signaling is required for efficient establishment of MHV68 latency.

, 2015
Mice were infected intranasally with 1,000 pfu of MHV68-H2bYFP and splenocytes were harvested at the indicated time points. (A) Representative flow plots showing identification of YFP+ B cells at d16 post-infection.
Samuel H. Speck (70359), Christopher M. Collins (309503)   +1 more
core   +1 more source

Label-free, quantitative phosphoproteomic analyses identify phosphoproteins induced and repressed in MHV68 infection.

, 2013
(A) Serum-starved 3T3 fibroblasts were mock-infected or infected at MOI = 5 PFU/cell, and cells were harvested 18 h post-infection, the timepoint for which tryptic peptides were enriched by TiO2 IMAC and identified by high resolution mass spectrometry ...
Daniel E. Voth (196250), J. Craig Forrest (308744), James A. Stahl (460566), Shweta S. Chavan (460567), Jeffrey M. Sifford (460568), Veronica MacLeod (460569), Ricky D. Edmondson (460570)   +6 more
core   +1 more source

Distribution of M2 null virus in newly formed, marginal zone and follicular B cells in the spleen at the peak of latency is similar to wild type MHV68.

, 2013
(A and B) Insertion of a YFP expression cassette into the viral genome, or addition of an AU1 epitope tag on the C-terminus of M2, did not alter the phenotype of the M2 null virus.
Neal N. Iwakoshi (369025), Justin B. Mendel (369024), Samuel H. Speck (70359), Christopher M. Collins (309503), Xiaozhen Liang (206573)   +4 more
core   +1 more source

Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models

mBio
Cancers associated with the oncogenic gammaherpesviruses, Epstein-Barr virus and Kaposi sarcoma herpesvirus, are notable for their constitutive activation of the transcription factor signal transducer and activator of transcription 3 (STAT3).
Chad H. Hogan, Shana M. Owens, Glennys V. Reynoso, Yifei Liao, Thomas J. Meyer, Monika A. Zelazowska, Bin Liu, Xiaofan Li, Anna K. Grosskopf, Camille Khairallah, Varvara Kirillov, Nancy C. Reich, Brian S. Sheridan, Kevin M. McBride, Benjamin E. Gewurz, Heather D. Hickman, J. Craig Forrest, Laurie T. Krug   +17 more
doaj   +1 more source

CDKs, ERK1/2, and c-Jun are required for efficient MHV68 replication.

, 2013
(A) 3T3 fibroblasts were treated with vehicle (DMSO), roscovitine, U0126, or 5-iodotubercidin at 10 µM concentration prior to infection with MHV68 at MOI = 10 PFU/cell.
Daniel E. Voth (196250), J. Craig Forrest (308744), James A. Stahl (460566), Shweta S. Chavan (460567), Jeffrey M. Sifford (460568), Veronica MacLeod (460569), Ricky D. Edmondson (460570)   +6 more
core   +1 more source

Herpesviruses hijack ISGylation to promote viral capsid assembly. [PDF]

Sci Adv
Li S, Feng S, Liu Y, Qin C, Zhang J, Saito T, Xie X, Fu W, Wang R, Zheng Y, Shu Z, Yeh W, Sasaki S, Tjokro N, Chen L, Munger J, Yuan W, Jung J, Chen C, Feng P.   +19 more
europepmc   +1 more source

IL-22 promotes the establishment of chronic gammaherpesvirus infection by supporting the germinal center response. [PDF]

PLoS Pathog
Majeed ST, Bradford SM, Jondle CN.
europepmc   +1 more source

Early-life gammaherpesvirus infection results in an expanded long-term latent reservoir. [PDF]

Front Cell Infect Microbiol
Manzi MS, Phophi L, de Oca JMF, Wilt HM, Ensberg KJ, Feswick A, Karst SM, Tibbetts SA.   +7 more
europepmc   +1 more source

Sex-specific in utero reprogramming of lung immunity. [PDF]

Mucosal Immunol
Maxwell A, Couturier A, Nguyen AT, Schick S, Singh A, Findeis E, Ramadoss J, Westrick J, Peraino N, Stemmer PM, Levin AM, Mor G, Ding J.   +12 more
europepmc   +1 more source

A combination of proviral and antiviral roles of CD11c- and T-bet-expressing B cells defines parameters of chronic murine gammaherpesvirus infection. [PDF]

mBio
Johansen ER, Bradeen XG, Xie EV, Dittel BN, Leadbetter EA, Tarakanova VL.   +5 more
europepmc   +1 more source